Biological functions of angiotensin and its receptors

T Matsusaka, I Ichikawa - Annual Review of Physiology, 1997 - annualreviews.org
▪ Abstract Angiotensin receptors are present in a number of organs and systems including
heart, kidney, gonad, and placenta; pituitary and adrenal glands; the peripheral vessels, and
the central nervous system. This octapeptide exerts diverse effects that include induction of
cell hypertrophy and/or hyperplasia and a stimulation of hormone synthesis and ion
transport in the heart, kidney, and adrenal, primarily through type 1 (AT1) receptors. In the
kidney, several heterogeneous cell populations—endothelial, epithelial, and vascular …