Structure and function of P-glycoprotein in normal liver and small intestine

ZC Gatmaitan, IM Arias - Advances in pharmacology, 1993 - Elsevier
Publisher Summary This chapter discusses the structure and function of P-glycoprotein in
normal liver and small intestine. Mammalian cells selected for resistance to a single
cytotoxic agent display cross-resistance to a broad spectrum of structurally and functionally
unrelated compounds. This is the “multidrug resistance”(MDR) phenomenon. The
emergence of multidrug resistance in cultured cells is associated with the overexpression of
a membrane glycoprotein called “P-glycoprotein”(or Gp170). P-Glycoprotein appears to …