Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis
JW Heinecke - Atherosclerosis, 1998 - Elsevier
The oxidation hypothesis proposes that low density lipoprotein must be oxidatively modified
to trigger the pathological events of atheroscleosis. In this article, we evaluate recent studies
addressing the pathways that promote low density lipoprotein oxidation in vivo and the
impact of antioxidants on atherogenesis in animals, paying particular attention to the clinical
implications of these studies for the oxidation hypothesis.
to trigger the pathological events of atheroscleosis. In this article, we evaluate recent studies
addressing the pathways that promote low density lipoprotein oxidation in vivo and the
impact of antioxidants on atherogenesis in animals, paying particular attention to the clinical
implications of these studies for the oxidation hypothesis.