Antioxidants and atherosclerotic heart disease

MN Diaz, B Frei, JA Vita… - New England Journal of …, 1997 - Mass Medical Soc
MN Diaz, B Frei, JA Vita, JF Keaney Jr
New England Journal of Medicine, 1997Mass Medical Soc
Epidemiologic studies have demonstrated an association between increased intake of
antioxidant vitamins such as vitamin E and vitamin C and reduced morbidity and mortality
from coronary artery disease. This association has been explained on the basis of the
“oxidative-modification hypothesis” of atherosclerosis, which proposes that atherogenesis is
initiated by oxidation of the lipids in low-density lipoprotein (LDL), also termed lipid
peroxidation. As a corollary to this hypothesis, antioxidants that inhibit lipid peroxidation in …
Epidemiologic studies have demonstrated an association between increased intake of antioxidant vitamins such as vitamin E and vitamin C and reduced morbidity and mortality from coronary artery disease. This association has been explained on the basis of the “oxidative-modification hypothesis” of atherosclerosis, which proposes that atherogenesis is initiated by oxidation of the lipids in low-density lipoprotein (LDL), also termed lipid peroxidation. As a corollary to this hypothesis, antioxidants that inhibit lipid peroxidation in LDL should limit atherosclerosis and its clinical manifestations, such as myocardial infarction and stroke. In this review, we will evaluate the current literature involving antioxidants and vascular . . .
The New England Journal Of Medicine