Structure elucidation of a senescence cross-link from human extracellular matrix: implication of pentoses in the aging process
DR Sell, VM Monnier - Journal of Biological Chemistry, 1989 - ASBMB
Isolation and structure elucidation of an acid-resistant fluorescent molecule from human
extracellular matrix revealed the presence of an imidazo [4, 5-b] pyridinium molecule
comprising a lysine and an arginine residue cross-linked by a pentose. Structure
confirmation was achieved in vitro by the nonenzymatic reaction of ribose with lysine and
arginine residues. The cross-link, named pentosidine, could also be synthesized with
isomers of ribose, arabinose, xylose, and lyxose as well as by incubating young human …
extracellular matrix revealed the presence of an imidazo [4, 5-b] pyridinium molecule
comprising a lysine and an arginine residue cross-linked by a pentose. Structure
confirmation was achieved in vitro by the nonenzymatic reaction of ribose with lysine and
arginine residues. The cross-link, named pentosidine, could also be synthesized with
isomers of ribose, arabinose, xylose, and lyxose as well as by incubating young human …