Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease
PL Cohen, RA Eisenberg - Annual review of immunology, 1991 - annualreviews.org
The autosomal recessive lpr and gld genes induce in mice multiple autoantibodies and the
progressive accumulation of large numbers of non-malignant CD4-CD8-T lymphocytes. The
clinical syndromes and immune abnormalities associated with these two nonallelic genes
are nearly identical and are also highly dependent on background genes. MRL/lpr mice are
particularly severely affected, and they develop a syndrome that is serologically and
pathologically similar to human systemic lupus erythematosus (SLE). Abnormal cell marker …
progressive accumulation of large numbers of non-malignant CD4-CD8-T lymphocytes. The
clinical syndromes and immune abnormalities associated with these two nonallelic genes
are nearly identical and are also highly dependent on background genes. MRL/lpr mice are
particularly severely affected, and they develop a syndrome that is serologically and
pathologically similar to human systemic lupus erythematosus (SLE). Abnormal cell marker …