Analysis of the role of prostaglandins in the fertilization process
S Hayashi, Y Noda, T Mori - European Journal of Obstetrics & Gynecology …, 1988 - Elsevier
This study was designed to elucidate the role of prostaglandins (PG) in the fertilization
process, using indomethacin (ID), an inhibitor of PG biosynthesis, and mouse in vitro
fertilization as a model for analysis. Spermatozoal viability, as assessed via motility, was not
suppressed by ID at 100 and 150 μg/ml in 3-h incubation, but markedly by 200 μg/ml in 1-h
incubation. On the other hand, ovum viability was not affected even by 200 μg/ml ID in 5-h
incubation, as assessed via dye-excretion and morphology. Fertilization rates for 0, 100, 150 …
process, using indomethacin (ID), an inhibitor of PG biosynthesis, and mouse in vitro
fertilization as a model for analysis. Spermatozoal viability, as assessed via motility, was not
suppressed by ID at 100 and 150 μg/ml in 3-h incubation, but markedly by 200 μg/ml in 1-h
incubation. On the other hand, ovum viability was not affected even by 200 μg/ml ID in 5-h
incubation, as assessed via dye-excretion and morphology. Fertilization rates for 0, 100, 150 …
