[HTML][HTML] Evidence for an Anti-parallel Orientation of the Ligand-activated Human Androgen Receptor Dimer (∗)
E Langley, Z Zhou, EM Wilson - Journal of Biological Chemistry, 1995 - ASBMB
Domain interactions of the human androgen receptor (AR) dimer were investigated using a
protein-protein interaction assay in which the NH 2-and carboxyl-terminal regions of human
AR were fused to the Saccharomyces cerevisiae GAL4 DNA-binding domain and herpes
simplex virus VP16 transactivation domain to produce chimeric proteins. Transcriptional
activation of a GAL4 luciferase reporter vector up to 100-fold was greater than Fos/Jun
leucine zipper binding, indicating stable AR interaction between AR NH 2-terminal residues …
protein-protein interaction assay in which the NH 2-and carboxyl-terminal regions of human
AR were fused to the Saccharomyces cerevisiae GAL4 DNA-binding domain and herpes
simplex virus VP16 transactivation domain to produce chimeric proteins. Transcriptional
activation of a GAL4 luciferase reporter vector up to 100-fold was greater than Fos/Jun
leucine zipper binding, indicating stable AR interaction between AR NH 2-terminal residues …