Arachidonic acid metabolism in isolated pancreatic islets. V. The enantiomeric composition of 12-hydroxy-5, 8, 10, 14-eicosatetraenoic acid indicates synthesis by a …
J Turk, BA Wolf, RA Easom, JH Hughes… - Biochimica et Biophysica …, 1989 - Elsevier
Recent evidence indicates that the arachidonate metabolite 12-hydroxy-5, 8, 10, 14-
eicosatetraenoic acid (12-HETE) or its precursor may act as a second messenger in stimulus-
response coupling in a variety of cells including Aplysia neurons, adrenal glomerulosa cells,
and pancreatic islets. The compound 12 (S)-HETE is generated from the precursor 12 (S)-
hydroperoxy-5, 8, 10, 14-eicosatetraenoic acid (12 (S)-HPETE), which is a product of the 12-
lipoxygenase enzyme. Some cells have recently been found to produce the enantiomer 12 …
eicosatetraenoic acid (12-HETE) or its precursor may act as a second messenger in stimulus-
response coupling in a variety of cells including Aplysia neurons, adrenal glomerulosa cells,
and pancreatic islets. The compound 12 (S)-HETE is generated from the precursor 12 (S)-
hydroperoxy-5, 8, 10, 14-eicosatetraenoic acid (12 (S)-HPETE), which is a product of the 12-
lipoxygenase enzyme. Some cells have recently been found to produce the enantiomer 12 …
