Differential effect of shear stress on extracellular signal-regulated kinase and N-terminal jun kinase in endothelial cells: Gi2-and Gβ/γ-dependent signaling pathways
Shear stress differentially regulates production of many vasoactive factors at the level of
gene expression in endothelial cells that may be mediated by mitogen-activated protein
kinases, including extracellular signal-regulated kinase (ERK) and N-terminal Jun kinase
(JNK). Here we show, using bovine aortic endothelial cells (BAEC), that shear stress
differentially regulates ERK and JNK by mechanisms involving G i2 and pertussis toxin (PTx)-
insensitive G-protein-dependent pathways, respectively. Shear activated ERK with a rapid …
gene expression in endothelial cells that may be mediated by mitogen-activated protein
kinases, including extracellular signal-regulated kinase (ERK) and N-terminal Jun kinase
(JNK). Here we show, using bovine aortic endothelial cells (BAEC), that shear stress
differentially regulates ERK and JNK by mechanisms involving G i2 and pertussis toxin (PTx)-
insensitive G-protein-dependent pathways, respectively. Shear activated ERK with a rapid …
