Involvement of the small GTPase rho in integrin-mediated activation of mitogen-activated protein kinase
MW Renshaw, D Toksoz, MA Schwartz - Journal of Biological Chemistry, 1996 - jbc.org
Engagement and clustering of integrins triggers a number of intracellular signaling events,
including activation of the mitogen-activated protein (MAP) kinases Erk1 and Erk2. To
investigate the mechanism by which integrins mediate the activation of MAP kinases upon
binding of NIH 3T3 cells to fibronectin, we assessed the effects of both inhibiting and
activating the small GTPase Rho. We observed that inhibition of Rho by the Rho-specific
inhibitor C3 exoenzyme or by a dominant negative Rho A (RhoN19) inhibited MAP kinase …
including activation of the mitogen-activated protein (MAP) kinases Erk1 and Erk2. To
investigate the mechanism by which integrins mediate the activation of MAP kinases upon
binding of NIH 3T3 cells to fibronectin, we assessed the effects of both inhibiting and
activating the small GTPase Rho. We observed that inhibition of Rho by the Rho-specific
inhibitor C3 exoenzyme or by a dominant negative Rho A (RhoN19) inhibited MAP kinase …