Blood vessels have a unified mission to circulate blood throughout the body; however, they have additional diverse and specialized roles in various organs. For example, in the liver, discontinuous sinusoids, which are fenestrated capillaries with intercellular gaps and a fragmented basement membrane, facilitate delivery of macromolecules to highly metabolic hepatocytes. During embryonic development, discontinuous sinusoids also allow circulating hematopoietic progenitor and stem cells to populate the liver and promote blood cell differentiation. In this issue of the
Courtney T. Griffin, Siqi Gao
Title and authors | Publication | Year |
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Endothelial Zeb2 preserves the hepatic angioarchitecture and protects against liver fibrosis
W de Haan, W Dheedene, K Apelt, S Décombas-Deschamps, S Vinckier, S Verhulst, A Conidi, T Deffieux, M Staring, P Vandervoort, E Caluwé, M Lox, I Mannaerts, T Takagi, J Jaekers, G Berx, J Haigh, B Topal, A Zwijsen, Y Higashi, L van Grunsven, W van IJcken, E Mulugeta, M Tanter, F Lebrin, D Huylebroeck, A Luttun |
Cardiovascular Research | 2021 |