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Citations to this article

CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma
Jian Hong, … , Yi-Xin Zeng, Tiebang Kang
Jian Hong, … , Yi-Xin Zeng, Tiebang Kang
Published May 15, 2012
Citation Information: J Clin Invest. 2012;122(6):2165-2175. https://doi.org/10.1172/JCI61380.
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Research Article Oncology Article has an altmetric score of 1

CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma

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Abstract

Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies resistant to current chemotherapies or radiotherapies, which makes it urgent to identify new therapeutic targets for HCC. In this study, we found that checkpoint kinase 1 (CHK1) was frequently overexpressed and correlated with poor clinical outcome in patients with HCC. We further showed that the CHK1 inhibitor GÖ6976 was capable of sensitizing HCC cells to cisplatin, indicating that CHK1 may have oncogenic function in HCC. We found that CHK1 phosphorylated the tumor suppressor spleen tyrosine kinase (L) (SYK[L]) and identified the phosphorylation site at Ser295. Furthermore, CHK1 phosphorylation of SYK(L) promoted its subsequent proteasomal degradation. Expression of a nonphosphorylated mutant of SYK(L) was more efficient at suppressing proliferation, colony formation, mobility, and tumor growth in HCC lines. Importantly, a strong inverse correlation between the expression levels of CHK1 and SYK(L) was observed in patients with HCC. Collectively, our data demonstrate that SYK(L) is a substrate of CHK1 in tumor cells and suggest that targeting the CHK1/SYK(L) pathway may be a promising strategy for treating HCC.

Authors

Jian Hong, Kaishun Hu, Yunfei Yuan, Yi Sang, Qiangui Bu, Guihua Chen, Longjun Yang, Binkui Li, Pinzhu Huang, Dongtai Chen, Yi Liang, Ruhua Zhang, Jingxuan Pan, Yi-Xin Zeng, Tiebang Kang

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2009 Total
Citations: 1 4 4 9 6 8 5 9 6 3 4 10 5 1 75
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2020 (8)

Title and authors Publication Year
Role of spleen tyrosine kinase in liver diseases
DW Kurniawan, G Storm, J Prakash, R Bansal
World journal of gastroenterology : WJG 2020
TRIM11 facilitates chemoresistance in nasopharyngeal carcinoma by activating the β-catenin/ABCC9 axis via p62-selective autophagic degradation of Daple
R Zhang, SW Li, L Liu, J Yang, G Huang, Y Sang
Oncogenesis 2020
ATM‐Dependent Recruitment of BRD7 is required for Transcriptional Repression and DNA Repair at DNA Breaks Flanking Transcriptional Active Regions
K Hu, Y Li, W Wu, L Xie, H Yan, Y Cai, D Chen, Q Jiang, L Lin, Z Chen, JY Liao, Y Zhang, HP Koeffler, D Yin, E Song
Advanced Science 2020
Potential of modern circulating cell-free DNA diagnostic tools for detection of specific tumour cells in clinical practice
J Gašperšič, AV Paska
Biochemia Medica 2020
PARK2 promotes mitochondrial pathway of apoptosis and antimicrotubule drugs chemosensitivity via degradation of phospho-BCL-2
H Chen, Y Li, Y Li, Z Chen, L Xie, W Li, Y Zhu, H Xue, HP Koeffler, W Wu, K Hu, D Yin
Theranostics 2020
Diagnostic and prognostic value of MCM3 and its interacting proteins in hepatocellular carcinoma
HT Li, B Wei, ZQ Li, X Wang, WX Jia, YZ Xu, JY Liu, MN Shao, SX Chen, NF Mo, D Zhao, WP Zuo, J Qin, P Li, QL Zhang, XL Yang
Oncology Letters 2020
The genetic association between type 2 diabetic and hepatocellular carcinomas
Z Shi, Z Xiao, L Hu, Y Gao, J Zhao, Y Liu, G Shen, Q Xu, D Huang
Annals of translational medicine 2020
Clinical and functional significance of CHK1-S, an alternatively spliced isoform of the CHK1 gene, in hepatocellular carcinoma
G Hu, S Wang, Y Wang, Y Gao, H Zhu, M Liu, N Xu, L Wang
Journal of Cancer 2020

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