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Citations to this article

Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice
Emma C. Walker, … , T. John Martin, Natalie A. Sims
Emma C. Walker, … , T. John Martin, Natalie A. Sims
Published January 4, 2010
Citation Information: J Clin Invest. 2010;120(2):582-592. https://doi.org/10.1172/JCI40568.
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Research Article Bone biology Article has an altmetric score of 4

Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice

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Abstract

Effective osteoporosis therapy requires agents that increase the amount and/or quality of bone. Any modification of osteoclast-mediated bone resorption by disease or drug treatment, however, elicits a parallel change in osteoblast-mediated bone formation because the processes are tightly coupled. Anabolic approaches now focus on uncoupling osteoblast action from osteoclast formation, for example, by inhibiting sclerostin, an inhibitor of bone formation that does not influence osteoclast differentiation. Here, we report that oncostatin M (OSM) is produced by osteoblasts and osteocytes in mouse bone and that it has distinct effects when acting through 2 different receptors, OSM receptor (OSMR) and leukemia inhibitory factor receptor (LIFR). Specifically, mouse OSM (mOSM) inhibited sclerostin production in a stromal cell line and in primary murine osteoblast cultures by acting through LIFR. In contrast, when acting through OSMR, mOSM stimulated RANKL production and osteoclast formation. A key role for OSMR in bone turnover was confirmed by the osteopetrotic phenotype of mice lacking OSMR. Furthermore, in contrast to the accepted model, in which mOSM acts only through OSMR, mOSM inhibited sclerostin expression in Osmr–/– osteoblasts and enhanced bone formation in vivo. These data reveal what we believe to be a novel pathway by which bone formation can be stimulated independently of bone resorption and provide new insights into OSMR and LIFR signaling that are relevant to other medical conditions, including cardiovascular and neurodegenerative diseases and cancer.

Authors

Emma C. Walker, Narelle E. McGregor, Ingrid J. Poulton, Melissa Solano, Sueli Pompolo, Tania J. Fernandes, Matthew J. Constable, Geoff C. Nicholson, Jian-Guo Zhang, Nicos A. Nicola, Matthew T. Gillespie, T. John Martin, Natalie A. Sims

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Total
Citations: 6 13 13 15 20 10 9 6 8 4 8 7 3 6 3 3 1 135
Citation information
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Citations to this article in year 2018 (6)

Title and authors Publication Year
Osteocytogenesis: Roles of Physicochemical Factors, Collagen Cleavage and Exogenous Molecules
X Chen, L Wang, K Zhao, H Wang
Tissue Engineering Part B: Reviews 2018
Sera of patients with axial spondyloarthritis (axSpA) enhance osteoclastogenic potential of monocytes isolated from healthy individuals
M Korkosz, M Czepiel, Z Guła, M Stec, K Węglarczyk, M Rutkowska-Zapała, A Gruca, M Lenart, J Baran, J Gąsowski, P Błyszczuk, M Siedlar
BMC musculoskeletal disorders 2018
Mesenchymal stem cell-macrophage crosstalk and bone healing
J Pajarinen, T Lin, E Gibon, Y Kohno, M Maruyama, K Nathan, L Lu, Z Yao, SB Goodman
Biomaterials 2018
Oncostatin M promotes the osteogenic differentiation of mouse MC3T3‑E1osteoblasts through the regulation of monocyte chemotactic protein‑1
W Zheng, J Guan
Molecular medicine reports 2018
Regulatory mechanisms of sclerostin expression during bone remodeling
M Koide, Y Kobayashi
Journal of Bone and Mineral Metabolism 2018
The AB loop of oncostatin M (OSM) determines species-specific signaling in humans and mice
JM Adrian-Segarra, K Sreenivasan, P Gajawada, H Lörchner, T Braun, J Pöling
The Journal of biological chemistry 2018

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