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Citations to this article

The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma
Takayuki Harada, … , Akira Mitani, Kohichi Tanaka
Takayuki Harada, … , Akira Mitani, Kohichi Tanaka
Published July 2, 2007
Citation Information: J Clin Invest. 2007;117(7):1763-1770. https://doi.org/10.1172/JCI30178.
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Research Article Ophthalmology Article has an altmetric score of 3

The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma

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Abstract

Glaucoma, a progressive optic neuropathy due to retinal ganglion cell (RGC) degeneration, is one of the leading causes of irreversible blindness. Although glaucoma is often associated with elevated intraocular pressure (IOP), IOP elevation is not detected in a significant subset of glaucomas, such as normal tension glaucoma (NTG). Moreover, in some glaucoma patients, significant IOP reduction does not prevent progression of the disease. Thus, understanding IOP-independent mechanisms of RGC loss is important. Here, we show that mice deficient in the glutamate transporters GLAST or EAAC1 demonstrate spontaneous RGC and optic nerve degeneration without elevated IOP. In GLAST-deficient mice, the glutathione level in Müller glia was decreased; administration of glutamate receptor blocker prevented RGC loss. In EAAC1-deficient mice, RGCs were more vulnerable to oxidative stress. These findings suggest that glutamate transporters are necessary both to prevent excitotoxic retinal damage and to synthesize glutathione, a major cellular antioxidant and tripeptide of glutamate, cysteine, and glycine. We believe these mice are the first animal models of NTG that offer a powerful system for investigating mechanisms of neurodegeneration in NTG and developing therapies directed at IOP-independent mechanisms of RGC loss.

Authors

Takayuki Harada, Chikako Harada, Kazuaki Nakamura, Hun-Meng A. Quah, Akinori Okumura, Kazuhiko Namekata, Tadashiro Saeki, Makoto Aihara, Hiroshi Yoshida, Akira Mitani, Kohichi Tanaka

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Total
Citations: 5 9 7 8 9 12 13 9 10 13 9 8 7 6 4 8 5 6 148
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2015 (9)

Title and authors Publication Year
Glutamate Transporters/Na+, K+-ATPase Involving in the Neuroprotective Effect as a Potential Regulatory Target of Glutamate Uptake
LN Zhang, YJ Sun, LX Wang, ZB Gao
Molecular Neurobiology 2015
Arundic acid attenuates retinal ganglion cell death by increasing glutamate/aspartate transporter expression in a model of normal tension glaucoma
M Yanagisawa, T Aida, T Takeda, K Namekata, T Harada, R Shinagawa, K Tanaka
Cell Death and Disease 2015
T-Helper1/T-Helper2 Cytokine Imbalance in the Iris of Patients with Glaucoma
MS Wong, P Huang, W Li, Y Li, SS Zhang, C Zhang, M Moser
PloS one 2015
Spermidine promotes retinal ganglion cell survival and optic nerve regeneration in adult mice following optic nerve injury
T Noro, K Namekata, A Kimura, X Guo, Y Azuchi, C Harada, T Nakano, H Tsuneoka, T Harada
Cell Death and Disease 2015
The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells
E Pedraz-Cuesta, S Christensen, AA Jensen, NF Jensen, L Bunch, MU Romer, N Brünner, J Stenvang, SF Pedersen
BMC Cancer 2015
Experimentally Induced Mammalian Models of Glaucoma
M Ishikawa, T Yoshitomi, CF Zorumski, Y Izumi
BioMed Research International 2015
A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin
K Sirohi, A Kumari, V Radha, G Swarup, TS Acott
PloS one 2015
Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities
KA Fernandes, JM Harder, PA Williams, RL Rausch, AE Kiernan, KS Nair, MG Anderson, SW John, GR Howell, RT Libby
Experimental Eye Research 2015
The association between systemic oxidative stress and ocular blood flow in patients with normal-tension glaucoma
N Himori, H Kunikata, Y Shiga, K Omodaka, K Maruyama, H Takahashi, T Nakazawa
Graefe's Archive for Clinical and Experimental Ophthalmology 2015

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