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Citations to this article

Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction
Cinzia Perrino, … , Oliver Smithies, Howard A. Rockman
Cinzia Perrino, … , Oliver Smithies, Howard A. Rockman
Published June 1, 2006
Citation Information: J Clin Invest. 2006;116(6):1547-1560. https://doi.org/10.1172/JCI25397.
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Research Article Cardiology Article has an altmetric score of 12

Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction

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Abstract

For over a century, there has been intense debate as to the reason why some cardiac stresses are pathological and others are physiological. One long-standing theory is that physiological overloads such as exercise are intermittent, while pathological overloads such as hypertension are chronic. In this study, we hypothesized that the nature of the stress on the heart, rather than its duration, is the key determinant of the maladaptive phenotype. To test this, we applied intermittent pressure overload on the hearts of mice and tested the roles of duration and nature of the stress on the development of cardiac failure. Despite a mild hypertrophic response, preserved systolic function, and a favorable fetal gene expression profile, hearts exposed to intermittent pressure overload displayed pathological features. Importantly, intermittent pressure overload caused diastolic dysfunction, altered β-adrenergic receptor (βAR) function, and vascular rarefaction before the development of cardiac hypertrophy, which were largely normalized by preventing the recruitment of PI3K by βAR kinase 1 to ligand-activated receptors. Thus stress-induced activation of pathogenic signaling pathways, not the duration of stress or the hypertrophic growth per se, is the molecular trigger of cardiac dysfunction.

Authors

Cinzia Perrino, Sathyamangla V. Naga Prasad, Lan Mao, Takahisa Noma, Zhen Yan, Hyung-Suk Kim, Oliver Smithies, Howard A. Rockman

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Total
Citations: 2 4 10 8 10 3 5 5 8 5 12 6 6 5 6 5 10 2 6 1 119
Citation information
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Citations to this article in year 2017 (8)

Title and authors Publication Year
T cell costimulation blockade blunts pressure overload-induced heart failure
M Kallikourdis, E Martini, P Carullo, C Sardi, G Roselli, CM Greco, D Vignali, F Riva, AM Berre, TO Stølen, A Fumero, G Faggian, ED Pasquale, L Elia, C Rumio, D Catalucci, R Papait, G Condorelli
Nature Communications 2017
Murine Models of Heart Failure With Preserved Ejection Fraction
M Valero-Muñoz, W Backman, F Sam
JACC: Basic to Translational Science 2017
Short-Term Administration of Serelaxin Produces Predominantly Vascular Benefits in the Angiotensin II/L-NAME Chronic Heart Failure Model
JC McCarthy, M Aronovitz, JJ DuPont, TD Calamaras, IZ Jaffe, RM Blanton
JACC: Basic to Translational Science 2017
Molecular Mechanisms Underlying Cardiac Adaptation to Exercise
RB Vega, JP Konhilas, DP Kelly, LA Leinwand
Cell Metabolism 2017
Size matters: Finding growth pathways that protect the heart
JS Guseh, A Rosenzweig
Cell Research 2017
Cardiac damage in athlete’s heart: When the “supernormal” heart fails!
A Carbone, A DAndrea, L Riegler, R Scarafile, E Pezzullo, F Martone, R America, B Liccardo, M Galderisi, E Bossone, R Calabrò
World journal of cardiology 2017
Beneficial Effects of Paeoniflorin Enriched Extract on Blood Pressure Variability and Target Organ Damage in Spontaneously Hypertensive Rats
B Li, ZB Yang, SS Lei, J Su, MX Pang, C Yin, GY Chen, CW Shan, B Chen, HM Hu, SH Chen, GY Lv
Evidence-Based Complementary and Alternative Medicine 2017
β‐Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5) Nuclear Accumulation in Cardiomyocytes by B55α‐PP2A‐Mediated Dephosphorylation
KL Weeks, A Ranieri, A Karaś, BC Bernardo, AS Ashcroft, C Molenaar, JR McMullen, M Avkiran
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2017

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Referenced in 11 patents
Referenced in 1 clinical guideline sources
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