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Citations to this article

Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS
Kenneth Williams, … , Eliezer Masliah, R. Gilberto González
Kenneth Williams, … , Eliezer Masliah, R. Gilberto González
Published September 1, 2005
Citation Information: J Clin Invest. 2005;115(9):2534-2545. https://doi.org/10.1172/JCI22953.
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Research Article Virology

Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS

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Abstract

Difficulties in understanding the mechanisms of HIV neuropathogenesis include the inability to study dynamic processes of infection, cumulative effects of the virus, and contributing host immune responses. We used 1H magnetic resonance spectroscopy and studied monocyte activation and progression of CNS neuronal injury in a CD8 lymphocyte depletion model of neuroAIDS in SIV-infected rhesus macaque monkeys. We found early, consistent neuronal injury coincident with viremia and SIV infection/activation of monocyte subsets and sought to define the role of plasma virus and monocytes in contributing to CNS disease. Antiretroviral therapy with essentially non–CNS-penetrating agents resulted in slightly decreased levels of plasma virus, a significant reduction in the number of activated and infected monocytes, and rapid, near-complete reversal of neuronal injury. Robust macrophage accumulation and productive virus replication were found in brains of infected and CD8 lymphocyte–depleted animals, but no detectable virus and few scattered infiltrating macrophages were observed in CD8 lymphocyte–depleted animals compared with animals not receiving antiretroviruses that were sacrificed at the same time after infection. These results underscore the role of activated monocytes and monocyte infection outside of the brain in driving CNS disease.

Authors

Kenneth Williams, Susan Westmoreland, Jane Greco, Eva Ratai, Margaret Lentz, Woong-Ki Kim, Robert A. Fuller, John P. Kim, Patrick Autissier, Prahbat K. Sehgal, Raymond F. Schinazi, Norbert Bischofberger, Michael Piatak Jr., Jeffrey D. Lifson, Eliezer Masliah, R. Gilberto González

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Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 1 4 2 3 2 2 5 4 4 6 9 3 3 15 8 6 11 2 6 1 97
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2014 (9)

Title and authors Publication Year
Elevated Numbers of CD163 + Macrophages in Hearts of Simian Immunodeficiency Virus-Infected Monkeys Correlate with Cardiac Pathology and Fibrosis
JA Walker, ML Sulciner, KD Nowicki, AD Miller, TH Burdo, KC Williams
AIDS Research and Human Retroviruses 2014
Animal models of HIV peripheral neuropathy
TH Burdo, AD Miller
Future Virology 2014
CD8+ T Cells Maintain Suppression of Simian Immunodeficiency Virus in the Central Nervous System
MC Marcondes, B Morsey, K Emanuel, BG Lamberty, CT Flynn, HS Fox
The Journal of Infectious Diseases 2014
The importance of monocytes and macrophages in HIV pathogenesis, treatment, and cure:
JH Campbell, AC Hearps, GE Martin, KC Williams, SM Crowe
AIDS 2014
Anti-α4 Antibody Treatment Blocks Virus Traffic to the Brain and Gut Early, and Stabilizes CNS Injury Late in Infection
JH Campbell, EM Ratai, P Autissier, DJ Nolan, S Tse, AD Miller, RG González, M Salemi, TH Burdo, KC Williams, DC Douek
2014
Imaging Neuroinflammation? A Perspective from MR Spectroscopy: Imaging Neuroinflammation
NM Zahr, D Mayer, T Rohlfing, EV Sullivan, A Pfefferbaum
Brain Pathology 2014
Longitudinal cerebral metabolic changes in pig-tailed macaques infected with the neurovirulent virus SIVsmmFGb
CX Li, X Zhang, A Komery, Y Li, H Mao, JG Herndon, FJ Novembre
Journal of Neurovirology 2014
Chronic Central Nervous System Expression of HIV-1 Tat Leads to Accelerated Rarefaction of Neocortical Capillaries and Loss of Red Blood Cell Velocity Heterogeneity
JN Silva, O Polesskaya, HS Wei, IY Rasheed, JM Chamberlain, C Nishimura, C Feng, S Dewhurst
Microcirculation 2014
Plasma Cytokine Levels are Related to Brain Volumes in HIV-infected Individuals
A Gongvatana, S Correia, S Dunsiger, L Gauthier, KN Devlin, S Ross, B Navia, KT Tashima, S DeLaMonte, RA Cohen
Journal of Neuroimmune Pharmacology 2014

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