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Citations to this article

Age-dependent incidence, time course, and consequences of thymic renewal in adults
Frances T. Hakim, … , Crystal L. Mackall, Ronald E. Gress
Frances T. Hakim, … , Crystal L. Mackall, Ronald E. Gress
Published April 1, 2005
Citation Information: J Clin Invest. 2005;115(4):930-939. https://doi.org/10.1172/JCI22492.
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Article Article has an altmetric score of 15

Age-dependent incidence, time course, and consequences of thymic renewal in adults

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Abstract

Homeostatic regulation of T cells involves an ongoing balance of new T cell generation, peripheral expansion, and turnover. The recovery of T cells when this balance is disrupted provides insight into the mechanisms that govern homeostasis. In a long-term, single cohort study, we assessed the role of thymic function after autologous transplant in adults, correlating serial computed tomography imaging of thymic size with concurrent measurements of peripheral CD4+ T cell populations. We established the age-dependent incidence, time course, and duration of thymic enlargement in adults and demonstrated that these changes were correlated with peripheral recovery of naive CD45RA+CD62L+ and signal-joint TCR rearrangement excision circle–bearing CD4+ populations with broad TCR diversity. Furthermore, we demonstrated that renewed thymopoiesis was critical for the restoration of peripheral CD4+ T cell populations. This recovery encompassed the recovery of normal CD4+ T cell numbers, a low ratio of effector to central memory cells, and a broad repertoire of TCR Vβ diversity among these memory cells. These data define the timeline and consequences of renewal of adult thymopoietic activity at levels able to quantitatively restore peripheral T cell populations. They further suggest that structural thymic regrowth serves as a basis for the regeneration of peripheral T cell populations.

Authors

Frances T. Hakim, Sarfraz A. Memon, Rosemarie Cepeda, Elizabeth C. Jones, Catherine K. Chow, Claude Kasten-Sportes, Jeanne Odom, Barbara A. Vance, Barbara L. Christensen, Crystal L. Mackall, Ronald E. Gress

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 4 5 6 9 8 8 10 9 7 9 3 5 11 7 9 16 16 15 11 5 2 175
Citation information
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Citations to this article in year 2020 (8)

Title and authors Publication Year
Immune cell repertoires in breast cancer patients after adjuvant chemotherapy
Claire E Gustafson, Rohit R. Jadhav, Wenqiang Cao, Qian Qi, Mark Pegram, Lu Tian, Cornelia M. Weyand, Jörg J. Goronzy
JCI Insight 2020
T cell regeneration after immunological injury
E Velardi, JJ Tsai, MR van den Brink
Nature Reviews Immunology 2020
Evaluating Thymic Function After Human Hematopoietic Stem Cell Transplantation in the Personalized Medicine Era
A Gaballa, E Clave, M Uhlin, A Toubert, LC Arruda
Frontiers in immunology 2020
Thymic Engraftment by in vitro-Derived Progenitor T Cells in Young and Aged Mice
J Singh, M Mohtashami, G Anderson, JC Zúñiga-Pflücker
Frontiers in immunology 2020
Homeostatic Cytokines Drive Epigenetic Reprogramming of Activated T Cells into a “Naive-Memory” Phenotype
G Frumento, K Verma, W Croft, A White, J Zuo, Z Nagy, S Kissane, G Anderson, P Moss, FE Chen
iScience 2020
Postnatal Involution and Counter-Involution of the Thymus
JE Cowan, Y Takahama, A Bhandoola, I Ohigashi
Frontiers in immunology 2020
Co-culture Systems of Drug-Treated Acute Myeloid Leukemia Cells and T Cells for In Vitro and In Vivo Study
Li Y, Su R, Chen J
2020
Alterations of Specific Lymphocytic Subsets with Aging and Age-Related Metabolic and Cardiovascular Diseases
Chen YJ, Liao YJ, Tram VT, Lin CH, Liao KC, Liu CL
Life Sciences 2020

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