Ribozyme-mediated functional repair of mutant cClC-1. (a and b) Representative whole-cell voltage-clamp recordings of HEK-293 cells transiently expressing wild-type cClC-1 (a) and stably expressing T268M (b). (c–f) Representative tail current traces from wild-type cClC-1 (c), T268M (d), and two ribozyme-transfected cells: full repair (e) and partial repair (f). Current traces recorded at –120 mV following a 0-mV prepulse are shown as bold black lines in c–f.