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Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury
John A. Belperio, … , Roderick J. Phillips, Robert M. Strieter
John A. Belperio, … , Roderick J. Phillips, Robert M. Strieter
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1703-1716. https://doi.org/10.1172/JCI15849.
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Article Aging

Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury

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Abstract

Research Article

Authors

John A. Belperio, Michael P. Keane, Marie D. Burdick, Vedang Londhe, Ying Ying Xue, Kewang Li, Roderick J. Phillips, Robert M. Strieter

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Figure 7

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(a) CXCR2 mRNA expression is markedly elevated during VILI. RT-PCR deter...
(a) CXCR2 mRNA expression is markedly elevated during VILI. RT-PCR determination of CXCR2 mRNA in lung homogenates from mice placed on either high– or low–peak pressure/stretch ventilator protocol, or from normal nonventilated mice. Semiquantitative results are expressed as a ratio of each PCR product to β-actin band density (n = 4 mice per group). *P < 0.02. (b and c) FACS analysis of CXCR2. (b) Total number of leukocytes (CD45-positive cells) with cell surface expression of CXCR2 in whole-lung digest homogenates from mice placed on either high– or low–peak pressure/stretch ventilator protocol, or from normal nonventilated mice (n = 3 mice per group). *P < 0.02. (c) Total number of nonleukocytes (CD45-negative cells) with cell surface expression of CXCR2 in whole-lung digest homogenates from mice placed on either high– or low–peak pressure/stretch ventilator protocol, or from normal nonventilated mice (n = 3 mice per group). *P < 0.02.

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