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Citations to this article

Prolonged adaptive immune activation in COVID-19: implications for maintenance of long-term immunity?
Philip A. Mudd, Kenneth E. Remy
Philip A. Mudd, Kenneth E. Remy
Published October 26, 2020
Citation Information: J Clin Invest. 2021;131(1):e143928. https://doi.org/10.1172/JCI143928.
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Commentary Article has an altmetric score of 26

Prolonged adaptive immune activation in COVID-19: implications for maintenance of long-term immunity?

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Abstract

Ongoing observational clinical research has prioritized understanding the human immune response to SARS-CoV-2 during the coronavirus disease 2019 (COVID-19) pandemic. Several recent studies suggest that immune dysregulation with early and prolonged adaptive immune system activation can result in cellular exhaustion. In this issue of the JCI, Files et al. compared cellular immune phenotypes during the first two months of COVID-19 in hospitalized and less severe, non-hospitalized patients. The authors utilized flow cytometry to analyze circulating peripheral blood mononuclear cells. Both patient cohorts maintained B and T cell phenotypes consistent with activation and cellular exhaustion throughout the first two months of infection. Additionally, follow-up samples from the non-hospitalized patient cohort showed that activation markers and cellular exhaustion increased over time. These findings illustrate the persistent nature of the adaptive immune system changes that have been noted in COVID-19 and suggest longer term effects that may shape the maintenance of immunity to SARS-CoV-2.

Authors

Philip A. Mudd, Kenneth E. Remy

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Total citations by year

Year: 2025 2023 2022 2021 Total
Citations: 1 3 5 6 15
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2023 (3)

Title and authors Publication Year
The role of immune activation and antigen persistence in acute and long COVID.
Opsteen S, Files JK, Fram T, Erdmann N
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2023
Gut Microbiota and Mitochondria: Health and Pathophysiological Aspects of Long COVID.
Ailioaie LM, Ailioaie C, Litscher G
International journal of molecular sciences 2023
Concurrent glomerular PCDH7 deposits in PLA2R-associated membranous nephropathy.
Fu N, Yuan S, Yang G, Li H, Wang T
CEN Case Reports 2023

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