Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Myelin-specific CD8+ T cells exacerbate brain inflammation in CNS autoimmunity
Catriona A. Wagner, … , Denny Liggitt, Joan M. Goverman
Catriona A. Wagner, … , Denny Liggitt, Joan M. Goverman
Published October 1, 2019
Citation Information: J Clin Invest. 2020;130(1):203-213. https://doi.org/10.1172/JCI132531.
View: Text | PDF
Research Article Autoimmunity Article has an altmetric score of 26

Myelin-specific CD8+ T cells exacerbate brain inflammation in CNS autoimmunity

  • Text
  • PDF
Abstract

Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the CNS. Although CD4+ T cells are implicated in MS pathogenesis and have been the main focus of MS research using the animal model experimental autoimmune encephalomyelitis (EAE), substantial evidence from patients with MS points to a role for CD8+ T cells in disease pathogenesis. We previously showed that an MHC class I–restricted epitope of myelin basic protein (MBP) is presented in the CNS during CD4+ T cell–initiated EAE. Here, we investigated whether naive MBP-specific CD8+ T cells recruited to the CNS during CD4+ T cell–initiated EAE engaged in determinant spreading and influenced disease. We found that the MBP-specific CD8+ T cells exacerbated brain but not spinal cord inflammation. We show that a higher frequency of monocytes and monocyte-derived cells presented the MHC class I–restricted MBP ligand in the brain compared with the spinal cord. Infiltration of MBP-specific CD8+ T cells enhanced ROS production in the brain only in these cell types and only when the MBP-specific CD8+ T cells expressed Fas ligand (FasL). These results suggest that myelin-specific CD8+ T cells may contribute to disease pathogenesis via a FasL-dependent mechanism that preferentially promotes lesion formation in the brain.

Authors

Catriona A. Wagner, Pamela J. Roqué, Trevor R. Mileur, Denny Liggitt, Joan M. Goverman

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 Total
Citations: 6 13 13 14 10 5 1 62
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2022 (14)

Title and authors Publication Year
T-cell surveillance of the human brain in health and multiple sclerosis
J Smolders, M van Luijn, C Hsiao, J Hamann
Seminars in Immunopathology 2022
Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis
J Luoqian, W Yang, X Ding, Q Tuo, Z Xiang, Z Zheng, Y Guo, L Li, P Guan, S Ayton, B Dong, H Zhang, H Hu, P Lei
Cellular and Molecular Immunology 2022
Effects of cigarette smoke exposure on a mouse model of multiple sclerosis
J Ho, K Koshibu, W Xia, K Luettich, A Kondylis, L Garcia, B Phillips, M Peitsch, J Hoeng
Toxicology Reports 2022
Glatiramer Acetate Immunomodulation: Evidence of Neuroprotection and Cognitive Preservation
A Kasindi, D Fuchs, Y Koronyo, A Rentsendorj, K Black, M Koronyo-Hamaoui
Cells 2022
Incidence and Risk Factors for Cerebrovascular-Specific Mortality in Patients with Colorectal Cancer: A Registry-Based Cohort Study Involving 563,298 Patients
Z Dai, M Tang, Y Chen, T Zhang, J Li, G Lv, Y Yan, Z Ouyang, W Huang, M Zou
Cancers 2022
Accumulation of pTreg cells is detrimental in late‐onset (aged) mouse model of multiple sclerosis
Wang W, Thomas R, Oh J, Su D
Aging Cell 2022
Autoreactive lymphocytes in multiple sclerosis: Pathogenesis and treatment target
Liu R, Du S, Zhao L, Jain S, Sahay K, Rizvanov A, Lezhnyova V, Khaibullin T, Martynova E, Khaiboullina S, Baranwal M
Frontiers in immunology 2022
Experimental and Clinical Biomarkers for Progressive Evaluation of Neuropathology and Therapeutic Interventions for Acute and Chronic Neurological Disorders
Reddy DS, Abeygunaratne HN
International journal of molecular sciences 2022
B Cells Drive MHC Class I–Restricted CD4 T Cells to Induce Spontaneous Central Nervous System Autoimmunity
Matter AL, Liggitt D, Goverman JM
2022
Targeting transmembrane-domain-less MOG expression to platelets prevents disease development in experimental autoimmune encephalomyelitis
Cai Y, Schroeder JA, Jing W, Gurski C, Williams CB, Wang S, Dittel BN, Shi Q
Frontiers in immunology 2022
Accumulation of RIPK1 into mitochondria is requisite for oxidative stress-mediated necroptosis and proliferation in Rat Schwann cells
Wang B, Fu J, Chai Y, Liu Y, Chen Y, Yin J, Pu Y, Chen C, Wang F, Liu Z, Zheng L, Chen M
International journal of medical sciences 2022
Age related immune modulation of experimental autoimmune encephalomyelitis in PINK1 knockout mice
Cossu D, Yokoyama K, Sato S, Noda S, Sakanishi T, Sechi LA, Hattori N
Frontiers in immunology 2022
Tc17 cells in autoimmune diseases.
Peng Y, Deng X, Zeng Q, Tang Y
Chinese Medical Journal 2022
Galactosylceramidase deficiency and pathological abnormalities in cerebral white matter of Krabbe disease.
Iacono D, Koga S, Peng H, Manavalan A, Daiker J, Castanedes-Casey M, Martin NB, Herdt AR, Gelb MH, Dickson DW, Lee CW
Neurobiology of Disease 2022

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Picked up by 2 news outlets
Blogged by 1
Posted by 15 X users
129 readers on Mendeley
See more details