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Citations to this article

c-Abl regulates YAPY357 phosphorylation to activate endothelial atherogenic responses to disturbed flow
Bochuan Li, … , Yi Zhu, Ding Ai
Bochuan Li, … , Yi Zhu, Ding Ai
Published January 10, 2019
Citation Information: J Clin Invest. 2019;129(3):1167-1179. https://doi.org/10.1172/JCI122440.
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Research Article Vascular biology Article has an altmetric score of 2

c-Abl regulates YAPY357 phosphorylation to activate endothelial atherogenic responses to disturbed flow

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Abstract

Local flow patterns determine the uneven distribution of atherosclerotic lesions. This research aims to elucidate the mechanism of regulation of nuclear translocation of Yes-associated protein (YAP) under oscillatory shear stress (OSS) in the atheroprone phenotype of endothelial cells (ECs). We report here that OSS led to tyrosine phosphorylation and strong, continuous nuclear translocation of YAP in ECs that is dependent on integrin α5β1 activation. YAP overexpression in ECs blunted the anti-atheroprone effect of an integrin α5β1–blocking peptide (ATN161) in Apoe–/– mice. Activation of integrin α5β1 induced tyrosine, but not serine, phosphorylation of YAP in ECs. Blockage of integrin α5β1 with ATN161 abolished the phosphorylation of YAP at Y357 induced by OSS. Mechanistic studies showed that c-Abl inhibitor attenuated the integrin α5β1–induced YAP tyrosine phosphorylation. Furthermore, the phosphorylation of c-Abl and YAPY357 was significantly increased in ECs in atherosclerotic vessels of mice and in human plaques versus normal vessels. Finally, bosutinib, a tyrosine kinase inhibitor, markedly reduced the level of YAPY357 and the development of atherosclerosis in Apoe–/– mice. The c-Abl/YAPY357 pathway serves as a mechanism for the activation of integrin α5β1 and the atherogenic phenotype of ECs in response to OSS, and provides a potential therapeutic strategy for atherogenesis.

Authors

Bochuan Li, Jinlong He, Huizhen Lv, Yajin Liu, Xue Lv, Chenghu Zhang, Yi Zhu, Ding Ai

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 Total
Citations: 9 11 19 10 12 7 4 72
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2020 (7)

Title and authors Publication Year
The Roles of Integrin α5β1 in Human Cancer
J Hou, D Yan, Y Liu, P Huang, H Cui
OncoTargets and therapy 2020
Functional characterization of uveal melanoma oncogenes
J Ma, L Weng, BC Bastian, X Chen
Oncogene 2020
YAP and the RhoC regulator ARHGAP18, are required to mediate flow-dependent endothelial cell alignment
PR Coleman, AJ Lay, KK Ting, Y Zhao, J Li, S Jarrah, MA Vadas, JR Gamble
Cell Communication and Signaling 2020
Cx43 and the Actin Cytoskeleton: Novel Roles and Implications for Cell-Cell Junction-Based Barrier Function Regulation
RE Strauss, RG Gourdie
Biomolecules 2020
NEK1 Phosphorylation of YAP Promotes Its Stabilization and Transcriptional Output
I Khalil, I Ghosh, V Singh, J Chen, H Zhu, AD Benedetti
Cancers 2020
Laminar flow inhibits the Hippo/YAP pathway via autophagy and SIRT1-mediated deacetylation against atherosclerosis
P Yuan, Q Hu, X He, Y Long, X Song, F Wu, Y He, X Zhou
Cell Death and Disease 2020
Reconstruction of a lncRNA-Associated ceRNA Network in Endothelial Cells under Circumferential Stress
Z Huang, WA Winata, K Zhang, Y Zhao, Y Li, N Zhou, S Zhou, W Fu, B Qiao, G Li, Y Shao, J Zheng, R Dong
Cardiology Research and Practice 2020

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