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Citations to this article

Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry: evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency.
S L Waldrop, … , V C Maino, L J Picker
S L Waldrop, … , V C Maino, L J Picker
Published April 1, 1997
Citation Information: J Clin Invest. 1997;99(7):1739-1750. https://doi.org/10.1172/JCI119338.
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Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry: evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency.

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Abstract

The highly regulated secretion of effector cytokines by CD4+ T cells plays a critical role in immune protection against pathogens such as cytomegalovirus. Here, we directly compare the frequency and functional characteristics of cytomegalovirus-specific CD4+ memory/effector T cells in normal and HIV+ subjects using a novel, highly efficient multiparameter flow cytometric assay that detects the rapid intracellular accumulation of cytokine(s) after short-term (6 h) in vitro antigen stimulation. Responses in this assay correlate precisely with independent measures of sensitization history (e.g., seroreactivity), and allow the simultaneous assessment of multiple cytokines in single effector T cells. Healthy HIV- individuals manifested an average of 0.71, 0.72, 0.38, and 0.06% CD4+ T cells responding to cytomegalovirus with gamma-IFN, TNF-alpha, IL-2, and IL-4 production, respectively, with the simultaneous production of gamma-IFN, TNF-alpha, and IL-2 being the most common effector phenotype. Significantly, overall cytomegalovirus-specific CD4+ effector frequencies were markedly higher among 40% of HIV+ subjects (2.7-8.0%), and demonstrated a predominately polarized gamma-IFN+/TNF-alpha+/IL-2-/IL-4- phenotype. In contrast, CD4+ effector frequencies for heterologous, nonubiquitous viruses such as the mumps virus were low or absent in the HIV+ group. These data suggest the existence of homeostatic mechanisms in HIV disease that selectively preserve memory T cell populations reactive with ubiquitous pathogens such as cytomegalovirus-likely at the expense of T cell memory to more sporadically encountered infectious agents.

Authors

S L Waldrop, C J Pitcher, D M Peterson, V C Maino, L J Picker

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H Nakase, T Yoshino, Y Honzawa, T Chiba
Digestive Diseases and Sciences 2010
Cord blood transplantation: evolving strategies to improve engraftment and immune reconstitution
MP Escalón, KV Komanduri
Current Opinion in Oncology 2010
Soluble Recombinant CMVpp65 Spanning Multiple HLA Alleles for Reconstitution of Antiviral CD4+ and CD8+ T-Cell Responses After Allogeneic Stem Cell Transplantation
A Paine, M Oelke, S Tischer, HG Heuft, R Blasczyk, B Eiz-Vesper
Journal of Immunotherapy 2010
Interferon-γ and T-bet expression in a patient with toxoplasmic lymphadenopathy
K Jöhrens, V Moos, T Schneider, H Stein, I Anagnostopoulos
Human Immunology 2010
Circulating pro-inflammatory CD4posCD28null T cells are independently associated with cardiovascular disease in ESRD patients
MG Betjes, EE de Wit, W Weimar, NH Litjens
Nephrology Dialysis Transplantation 2010
Human cytomegalovirus-specific CD4+ and CD8+ T-cell response determination: Comparison of short-term (24h) assays vs long-term (7-day) infected dendritic cell assay in the immunocompetent and the immunocompromised host
P Zelini, D Lilleri, G Comolli, V Rognoni, A Chiesa, C Fornara, F Locatelli, F Meloni, G Gerna
Clinical Immunology 2010
Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases
VG Fowler, WM Scheld, AS Bayer
Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases 2010
High Throughput T Epitope Mapping and Vaccine Development
GL Pira, F Ivaldi, P Moretti, F Manca
Journal of Biomedicine and Biotechnology 2010
Autocrine production of beta-chemokines protects CMV-Specific CD4 T cells from HIV infection
JP Casazza, JM Brenchley, BJ Hill, R Ayana, D Ambrozak, M Roederer, DC Douek, MR Betts, RA Koup
PLoS pathogens 2009
A panel of artificial APCs expressing prevalent HLA alleles permits generation of cytotoxic T cells specific for both dominant and subdominant viral epitopes for adoptive therapy
AN Hasan, WJ Kollen, D Trivedi, A Selvakumar, B Dupont, M Sadelain, RJ O'Reilly
Journal of immunology (Baltimore, Md. : 1950) 2009
Herpes simplex virus type 2 tegument proteins contain subdominant T-cell epitopes detectable in BALB/c mice after DNA immunization and infection
WJ Muller, L Dong, A Vilalta, B Byrd, KM Wilhelm, CL McClurkan, M Margalith, C Liu, D Kaslow, J Sidney, A Sette, DM Koelle
Journal of General Virology 2009
Human Late Memory CD8 + T Cells Have a Distinct Cytokine Signature Characterized by CC Chemokine Production without IL-2 Production
TK Kim, LS John, ED Wieder, J Khalili, Q Ma, KV Komanduri
Journal of immunology (Baltimore, Md. : 1950) 2009
CD4 T-Cell-Mediated Heterologous Immunity between Mycobacteria and Poxviruses
KS Mathurin, GW Martens, H Kornfeld, RM Welsh
Journal of virology 2009
Preemptive Therapy for Systemic and Pulmonary Human Cytomegalovirus Infection in Lung Transplant Recipients
G Gerna, D Lilleri, V Rognoni, M Agozzino, F Meloni, T Oggionni, C Pellegrini, E Arbustini, AM D'Armini
American Journal of Transplantation 2009
T-box-expressed-in-T-cells (T-bet) expression by the tumor cells of hairy cell leukemia correlates with interferon-gammaproduction
K Jöhrens, K Jöhrens, V Moos, T Schneider, I Anagnostopoulos, K Jöhrens, V Moos, T Schneider, I Anagnostopoulos
Leukemia & Lymphoma 2009
A culture amplified multi-parametric intracellular cytokine assay (CAMP-ICC) for enhanced detection of antigen specific T-cell responses
CM Munier, JJ Zaunders, S Ip, DA Cooper, AD Kelleher
Journal of Immunological Methods 2009
War and Peace between Microbes: HIV-1 Interactions with Coinfecting Viruses
A Lisco, C Vanpouille, L Margolis
Cell Host & Microbe 2009
In vitro end points for the assessment of cellular immune response-modulating drugs
MP Fuggetta, G Lanzilli, D Fioretti, M Rinaldi
Expert Opinion on Drug Discovery 2009
Cytomegalovirus infection and disease in the new era of immunosuppression following solid organ transplantation
RA Fisher
Transplant Infectious Disease 2009
HIV-1 Tat Addresses Dendritic Cells to Induce a Predominant Th1-Type Adaptive Immune Response That Appears Prevalent in the Asymptomatic Stage of Infection
E Fanales-Belasio, S Moretti, V Fiorelli, A Tripiciano, MR Cossut, A Scoglio, B Collacchi, F Nappi, I Macchia, S Bellino, V Francavilla, A Caputo, G Barillari, M Magnani, ME Laguardia, A Cafaro, F Titti, P Monini, F Ensoli, B Ensoli
Journal of immunology (Baltimore, Md. : 1950) 2009
Human cytomegalovirus infection induces a rapid and sustained change in the expression of NK cell receptors on CD8+ T cells
A Stijn, AT Rowshani, SL Yong, F Baas, E Roosnek, IJ Berge, RA van Lier
Journal of immunology (Baltimore, Md. : 1950) 2008
Serial Assessment of Immune Status by Circulating CD8+ Effector T Cell Frequencies for Posttransplant Infectious Complications
S Uemoto, K Ozawa, H Egawa, Y Takada, H Sato, S Teramukai, M Kasahara, K Ogawa, M Ono, K Takai, M Fukushima, K Inaba, K Tanaka
Clinical and Developmental Immunology 2008
Impact of preexisting circulating effector T cells on the outcome of ABO-incompatible adult LDLT
H Egawa, K Ozawa, Y Takada, S Teramukai, A Mori, M Kasahara, K Ogawa, Y Ogura, F Oike, T Kaido, M Ono, H Sato, K Takai, S Uemoto
Digestive Diseases and Sciences 2008
Early Depletion ofMycobacterium tuberculosis–Specific T Helper 1 Cell Responses after HIV‐1 Infection
C Geldmacher, A Schuetz, N Ngwenyama, JP Casazza, E Sanga, E Saathoff, C Boehme, S Geis, L Maboko, M Singh, F Minja, A Meyerhans, RA Koup, M Hoelscher
The Journal of Infectious Diseases 2008
A fingerprint left by cytomegalovirus infection in the human T cell compartment
PJ van de Berg, A Stijn, IJ Berge, RA van Lier
Journal of Clinical Virology 2008
Intestinal double-positive CD4+CD8+ T cells of neonatal rhesus macaques are proliferating, activated memory cells and primary targets for SIVMAC251 infection
X Wang, A Das, AA Lackner, RS Veazey, B Pahar
Blood 2008
Immune responses to mumps vaccine in adults who were vaccinated in childhood
R Hanna-Wakim, LL Yasukawa, P Sung, AM Arvin, HA Gans
The Journal of Infectious Diseases 2008
Precision and linearity targets for validation of an IFNgamma ELISPOT, cytokine flow cytometry, and tetramer assay using CMV peptides
HT Maecker, J Hassler, JK Payne, A Summers, K Comatas, M Ghanayem, MA Morse, TM Clay, HK Lyerly, S Bhatia, SA Ghanekar, VC Maino, C Delarosa, ML Disis
BMC Immunology 2008
S-antigen specific T helper type 1 response is present in Behcet's disease
C Zhao, P Yang, H He, X Lin, B Li, H Zhou, X Huang, A Kijlstra
Molecular vision 2008
Computational prediction and identification of dengue virus-specific CD4+ T-cell epitopes
JS Wen, LF Jiang, JM Zhou, HJ Yan, DY Fang
Virus Research 2008
Generation of specific effector and memory T cells with gut- and secondary lymphoid tissue- homing potential by oral attenuated CVD 909 typhoid vaccine in humans
R Wahid, R Salerno-Gonçalves, CO Tacket, MM Levine, MB Sztein
Mucosal Immunology 2008
Dissection of the CMV specific T-cell response is required for optimized cardiac transplant monitoring
A Kirchner, B Hoffmeister, G Cherepnev-G, S Fuhrmann, M Streitz, R Lachmann, T Bunde, P Meij, C Schönemann, R Hetzer, HB Lehmkuhl, R Volkmer-Engert, HD Volk, JW Gratama, F Kern
Journal of Medical Virology 2008
Human cytomegalovirus load measurement and its applications for pre-emptive therapy in patients undergoing hematopoietic stem cell transplantation
F Baldanti, D Lilleri, G Gerna
Hematological Oncology 2008
Monitoring human cytomegalovirus infection in transplant recipients
F Baldanti, D Lilleri, G Gerna
Journal of Clinical Virology 2008
CMV-specific T cell therapy
H Einsele, M Kapp, GU Grigoleit
Blood Cells, Molecules, and Diseases 2008
Dysregulated expression of T-helper cell responses and susceptibility to infections in high-risk liver transplant recipients
HY Sun, N Singh, TV Cacciarelli, C Wannstedt, MM Wagener, C Steele
Transplant Immunology 2008
Cancer Immunology
OJ Finn
New England Journal of Medicine 2008
Rapid identification and sorting of viable virus-reactive CD4+ and CD8+ T cells based on antigen-triggered CD137 expression
TC Wehler, M Karg, E Distler, A Konur, M Nonn, RG Meyer, C Huber, UF Hartwig, W Herr
Journal of Immunological Methods 2008
CD4 + T Cell Responses to Cytomegalovirus in Early Life: A Prospective Birth Cohort Study
DJ Miles, M Sande, S Kaye, S Crozier, O Ojuola, MS Palmero, M Sanneh, ES Touray, P Waight, S Rowland‐Jones, H Whittle, A Marchant
The Journal of Infectious Diseases 2008
Impairment of cytomegalovirus-specific cellular immune response as a risk factor for cytomegalovirus disease in transplant recipients
VN Motta, SL Martins
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] 2008
Human Cytomegalovirus
TE Shenk, MF Stinski
2008
Association between the HLA haplotype and the TCR-Vbeta repertoire of anti-hCMV specific memory T-cells in immunocompetent healthy adults
A Rodriguez-Caballero, AC Garcia-Montero, J Almeida, A Balanzategui, S Munoz-Criado, A Orfao
Cytometry. Part B, Clinical cytometry 2007
Clinical responders to antiviral therapy of chronic HCV infection show elevated antiviral CD4+ and CD8+ T-cell responses
V Pillai, WM Lee, DL Thiele, NJ Karandikar
Journal of Viral Hepatitis 2007
Cytotoxic T-cell-mediated defense against infections in human liver transplant recipients
K Tanaka, S Uemoto, H Egawa, Y Takada, K Ozawa, S Teramukai, M Kasahara, K Ogawa, M Ono, H Sato, K Takai, M Fukushima, K Inaba
Liver Transplantation 2007
Initial steroid bolus injection promotes vigorous CD8+ alloreactive responses toward early graft acceptance immediately after liver transplantation in humans
H Egawa, S Uemoto, Y Takada, K Ozawa, S Teramukai, H Haga, M Kasahara, K Ogawa, H Sato, M Ono, K Takai, M Fukushima, K Inaba, K Tanaka
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2007
Optimization and validation of an 8-color intracellular cytokine staining (ICS) assay to quantify antigen-specific T cells induced by vaccination
H Horton, EP Thomas, JA Stucky, I Frank, Z Moodie, Y Huang, YL Chiu, MJ McElrath, SC de Rosa
Journal of Immunological Methods 2007
Virus-specific T cell responses in macaques acutely infected with SHIV(sf162p3)
B Pahar, X Wang, J Dufour, AA Lackner, RS Veazey
Virology 2007
Ras/PI3Kinase/cofilin-independent activation of human CD45RA+ and CD45RO+ T cells by superagonistic CD28 stimulation
U Sester, GH Wabnitz, H Kirchgessner, Y Samstag
European Journal of Immunology 2007
Functional analysis of cytomegalovirus-specific T lymphocytes compared to tetramer assay in patients undergoing hematopoietic stem cell transplantation
Y Morita-Hoshi, Y Heike, M Kawakami, T Sugita, O Miura, SW Kim, SI Mori, T Fukuda, R Tanosaki, K Tobinai, Y Takaue
Bone Marrow Transplantation 2007
Identification and isolation of murine antigen-reactive T cells according to CD154 expression
D Kirchhoff, M Frentsch, P Leclerk, D Bumann, S Rausch, S Hartmann, A Thiel, A Scheffold
European Journal of Immunology 2007
Antigen-Specific T-Cell Immunity in Multiple Myeloma Patients is Restored Following High-Dose Therapy: Implications for Timing of Vaccination
IM Svane, K Nikolajsen, HE Johnsen
Scandinavian Journal of Immunology 2007
HIV/AIDS Vaccines: 2007
HL Robinson
Clinical Pharmacology & Therapeutics 2007
Frequency and phenotype of EHV-1 specific, IFN-γ synthesising lymphocytes in ponies: The effects of age, pregnancy and infection
R Paillot, JM Daly, R Luce, F Montesso, N Davis-Poynter, D Hannant, JH Kydd
Developmental & Comparative Immunology 2007
PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status
D Sauce, JR Almeida, M Larsen, L Haro, B Autran, GJ Freeman, V Appay
AIDS 2007
Perspectives in Medical Virology
KD Mena
Perspectives in Medical Virology 2007
Identification of an HLA-A24-restricted cytotoxic T lymphocyte epitope from human papillomavirus type-16 E6: the combined effects of bortezomib and interferon-gamma on the presentation of a cryptic epitope
S Morishima, Y Akatsuka, A Nawa, E Kondo, T Kiyono, H Torikai, T Nakanishi, Y Ito, K Tsujimura, K Iwata, K Ito, Y Kodera, Y Morishima, K Kuzushima, T Takahashi
International Journal of Cancer 2007
Détection par cytométrie en flux des sous-populations lymphocytaires T sécrétrices d'IL-2 et IFN-γ : optimisation de la technique et établissement des valeurs de référence
C Kallel, E Masy, P Duthilleul
Pathologie Biologie 2007
Adoptive immunotherapy of HCMV infection
M Kapp, SM Tan, H Einsele, GU Grigoleit
Cytotherapy 2007
Shift of CMV-specific CD4+ T-cells to the highly differentiated CD45RO−CD27− phenotype parallels loss of proliferative capacity and precedes progression to HIV-related CMV end-organ disease
C Bronke, CA Jansen, GH Westerlaken, IM de Cuyper, F Miedema, K Tesselaar, D Baarle
Clinical Immunology 2007
Human cytomegalovirus (CMV)-specific CD8+ T cell responses are reduced in HIV-infected individuals with a history of CMV disease despite CD4+ T cell recovery
KP Singh, JL Howard, SP Wild, SL Jones, J Hoy, SR Lewin
Clinical Immunology 2007
Hand Transplantation
M Lanzetta, JM Dubernard, P Petruzzo
2007
Changes in Paracrine Interleukin-2 Requirement, CCR7 Expression, Frequency, and Cytokine Secretion of Human Immunodeficiency Virus-Specific CD4+ T Cells Are a Consequence of Antigen Load
JC Tilton, MR Luskin, AJ Johnson, M Manion, CW Hallahan, JA Metcalf, M McLaughlin, RT Davey, M Connors
Journal of virology 2007
Human and Simian Immunodeficiency Virus-Mediated Upregulation of the Apoptotic Factor TRAIL Occurs in Antigen-Presenting Cells from AIDS-Susceptible but Not from AIDS-Resistant Species
N Kim, A Dabrowska, RG Jenner, A Aldovini
Journal of virology 2007
Induction and Evolution of Cytomegalovirus-Specific CD4 + T Cell Clonotypes in Rhesus Macaques
DA Price, AD Bitmansour, JB Edgar, JM Walker, MK Axthelm, DC Douek, LJ Picker
Journal of immunology (Baltimore, Md. : 1950) 2007
Multiple-Cytokine-Producing Antiviral CD4 T Cells Are Functionally Superior to Single-Cytokine-Producing Cells
S Kannanganat, C Ibegbu, L Chennareddi, HL Robinson, RR Amara
Journal of virology 2007
Acquisition of direct antiviral effector functions by CMV-specific CD4 + T lymphocytes with cellular maturation
JP Casazza, MR Betts, DA Price, ML Precopio, LE Ruff, JM Brenchley, BJ Hill, M Roederer, DC Douek, RA Koup
Journal of Experimental Medicine 2006
Increased hepatitis C virus (HCV)-specific CD4+CD25 + regulatory T lymphocytes and reduced HCV-specific CD4+ T cell response in HCV-infected patients with normal versus abnormal alanine aminotransferase levels
F Bolacchi, A Sinistro, C Ciaprini, F Demin, M Capozzi, FC Carducci, CM Drapeau, G Rocchi, A Bergamini
Clinical & Experimental Immunology 2006
Diminished frequency of hepatitis C virus specific interferon gamma secreting CD4+ T cells in human immunodeficiency virus/hepatitis C virus coinfected patients
G Harcourt, E Gomperts, S Donfield, P Klenerman
Gut 2006
VACUTAINER CPT and Ficoll density gradient separation perform equivalently in maintaining the quality and function of PBMC from HIV seropositive blood samples
JJ Ruitenberg, CB Mulder, VC Maino, AL Landay, SA Ghanekar
BMC Immunology 2006
Monitoring of Human Cytomegalovirus-Specific CD4+and CD8+T-Cell Immunity in Patients Receiving Solid Organ Transplantation
G Gerna, D Lilleri, C Fornara, G Comolli, L Lozza, C Campana, C Pellegrini, F Meloni, T Rampino
American Journal of Transplantation 2006
Intestinal double-positive CD4+CD8+ T cells are highly activated memory cells with an increased capacity to produce cytokines
B Pahar, AA Lackner, RS Veazey
European Journal of Immunology 2006
Antigen-specific T cell responses: Determination of their frequencies, homing properties, and effector functions in human whole blood
T Breinig, M Sester, U Sester, A Meyerhans
Methods 2006
Identification of immunodominant CD4+ T cell epitopes in patients withYersinia-induced reactive arthritis by cytometric cytokine secretion assay
A Thiel, P Wu, M Lanowska, J Dong, A Radbruch, J Sieper
Arthritis & Rheumatism 2006
Flow cytometric analysis of virus-specific T lymphocytes: Practicability of detection of HCMV-specific T lymphocytes in whole blood in patients after stem cell transplantation
S Buxbaum, FB Kraus, A Hahn, O Beck, B Kabartas, HW Doerr, B Ludwig
Journal of Immunological Methods 2006
Regulatory T cells generated during cytomegalovirus in vitro stimulation of mononuclear cells from HIV-infected individuals on HAART correlate with decreased lymphocyte proliferation
RD Jesser, S Li, A Weinberg
Virology 2006
Classification of human liver transplant recipients by their preoperative CD8+ T cell subpopulation and its relation to outcome
K Tanaka, K Ozawa, S Teramukai, Y Takada, H Egawa, S Kaihara, Y Fujimoto, Y Ogura, M Kasahara, M Ono, H Sato, K Takai, M Fukushima, N Minato
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2006
Adoptive T lymphocyte therapy to fight cytomegalovirus infection in immunodeficient hosts
U Grigoleit, M Kapp, H Einsele
Drug Discovery Today: Therapeutic Strategies 2006
Induction of a virus-specific effector–memory CD4 + T cell response by attenuated SIV infection
MC Gauduin, Y Yu, A Barabasz, A Carville, M Piatak, JD Lifson, RC Desrosiers, RP Johnson
Journal of Experimental Medicine 2006
Quantitative and Functional Differences between Peripheral Blood Myeloid Dendritic Cells from Patients with Pleural and Parenchymal Lung Tuberculosis
M Mendelson, WA Hanekom, S Ntutela, M Vogt, L Steyn, G Maartens, G Kaplan
Clinical and vaccine immunology : CVI 2006
Reduced Peripheral and Mucosal Tropheryma whipplei -Specific Th1 Response in Patients with Whipple’s Disease
V Moos, D Kunkel, T Marth, GE Feurle, B LaScola, R Ignatius, M Zeitz, T Schneider
Journal of immunology (Baltimore, Md. : 1950) 2006
Flow Cytometric Detection of Gamma Interferon Can Effectively Discriminate Mycobacterium bovis BCG-Vaccinated Cattle from M. bovis -Infected Cattle
P Sopp, CJ Howard, JC Hope
Clinical and vaccine immunology : CVI 2006
TIRC7 Inhibits T Cell Proliferation by Modulation of CTLA-4 Expression
GC Bulwin, T Heinemann, V Bugge, M Winter, A Lohan, M Schlawinsky, A Schulze, S Wälter, R Sabat, R Schülein, B Wiesner, RW Veh, J Löhler, RS Blumberg, HD Volk, N Utku
Journal of immunology (Baltimore, Md. : 1950) 2006
HLA-B27-restricted CD8+ T cell response to cartilage-derived self peptides in ankylosing spondylitis
P Atagunduz, H Appel, W Kuon, P Wu, A Thiel, PM Kloetzel, J Sieper
Arthritis & Rheumatism 2005
T cell subset and cytokine profiles in human visceral leishmaniasis during active and asymptomatic or sub-clinical infection with Leishmania donovani
A Hailu, D Baarle, GJ Knol, N Berhe, F Miedema, PA Kager
Clinical Immunology 2005
Impact of cryopreservation on tetramer, cytokine flow cytometry, and ELISPOT
HT Maecker, J Moon, S Bhatia, SA Ghanekar, VC Maino, JK Payne, K Kuus-Reichel, JC Chang, A Summers, TM Clay, MA Morse, HK Lyerly, C DeLaRosa, DP Ankerst, ML Disis
BMC Immunology 2005
Immune dysfunction in endotoxicosis: Role of nitric oxide produced by inducible nitric oxide synthase*
S Miki, N Takeyama, T Tanaka, T Nakatani
Critical Care Medicine 2005
Development of prophylactic and therapeutic vaccines against hepatitis C virus
G Leroux-Roels
Expert Review of Vaccines 2005
Direct access to CD4+ T cells specific for defined antigens according to CD154 expression
M Frentsch, O Arbach, D Kirchhoff, B Moewes, M Worm, M Rothe, A Scheffold, A Thiel
Nature Medicine 2005
Direct Ex Vivo Detection of HLA-DR3–Restricted Cytomegalovirus- and Mycobacterium tuberculosis–Specific CD4+ T Cells
C Bronke, NM Palmer, GH Westerlaken, M Toebes, GM van Schijndel, V Purwaha, KE van Meijgaarden, TN Schumacher, D Baarle, K Tesselaar, A Geluk
Human Immunology 2005
Lentiviral Vector-Transduced Dendritic Cells Induce Specific T Cell Response in a Nonhuman Primate Model
SK Kung, A Bonifacino, ME Metzger, GE Ringpis, RE Donahue, IS Chen
Human Gene Therapy 2005
Simultaneous quantification of human cytomegalovirus (HCMV)-specific CD4+ and CD8+T cells by a novel method using monocyte-derived HCMV-infected immature dendritic cells
L Lozza, D Lilleri, E Percivalle, C Fornara, G Comolli, MG Revello, G Gerna
European Journal of Immunology 2005
Cellular Immune Responses to Cytomegalovirus in Renal Transplant Recipients
R Radha, S Jordan, D Puliyanda, S Bunnapradist, A Petrosyan, N Amet, M Toyoda
American Journal of Transplantation 2005
T cell vaccines for microbial infections
HL Robinson, RR Amara
Nature Medicine 2005
Detection of adenovirus-specific T cells in children with adenovirus infection after allogeneic stem cell transplantation
T Feuchtinger, J Lücke, K Hamprecht, C Richard, R Handgretinger, M Schumm, J Greil, T Bock, D Niethammer, P Lang
British Journal of Haematology 2005
Measuring Ag-specific immune responses: understanding immunopathogenesis and improving diagnostics in infectious disease, autoimmunity and cancer
F Kern, G LiPira, JW Gratama, F Manca, M Roederer
Trends in Immunology 2005
Clinical, Microbiological, and Immunological Characteristics in HIV-Infected Subjects at Risk for DisseminatedMycobacterium aviumComplex Disease: An AACTG Study
RR MacGregor, R Hafner, JW Wu, RL Murphy, DC Perlman, LE Bermudez, CB Inderlied, LJ Picker, RS Wallis, JW Andersen, LF Mahon, SL Koletar, DM Peterson
AIDS Research and Human Retroviruses 2005
ACSD labelling and magnetic cell separation: a rapid method of separating antibody secreting cells from non-secreting cells
S Carroll, M Al-Rubeai
Journal of Immunological Methods 2005
Measuring Immunity
MT Stang, JH Yim
Measuring Immunity 2005
The Laboratory Primate
C Szabo
The Laboratory Primate 2005
Broadly targeted human cytomegalovirus-specific CD4 + and CD8 + T cells dominate the memory compartments of exposed subjects
AW Sylwester, BL Mitchell, JB Edgar, C Taormina, C Pelte, F Ruchti, PR Sleath, KH Grabstein, NA Hosken, F Kern, JA Nelson, LJ Picker
Journal of Experimental Medicine 2005
The Grand Challenge for the Future
SH Kaufmann, PH Lambert
2005
In vitro Induction of Myeloid Leukemia–Specific CD4 and CD8 T Cells by CD40 Ligand – Activated B Cells Gene Modified to Express Primary Granule Proteins
H Fujiwara, JJ Melenhorst, FE Ouriaghli, S Kajigaya, M Grube, G Sconocchia, K Rezvani, DA Price, NF Hensel, DC Douek, AJ Barrett
Clinical cancer research 2005
Optimization of CD4 + T Lymphocyte Response to Human Cytomegalovirus Nuclear IE1 Protein through Modifications of Both Size and Cellular Localization
S Delmas, L Martin, M Baron, JA Nelson, DN Streblow, JL Davignon
Journal of immunology (Baltimore, Md. : 1950) 2005
Immunogenic Properties of a Chimeric Plant Virus Expressing a Hepatitis C Virus (HCV)-Derived Epitope: New Prospects for an HCV Vaccine
G Piazzolla, M Nuzzaci, C Tortorella, E Panella, A Natilla, D Boscia, AD Stradis, P Piazzolla, S Antonaci
Journal of Clinical Immunology 2005
Virology Research
Peter B, Marta M, Nicholas L, Michael B. M, Christopher J. M
The Laboratory Primate 2005
Vaccination in humans generates broad T cell cytokine responses
SC de Rosa, FX Lu, J Yu, SP Perfetto, J Falloon, S Moser, TG Evans, R Koup, CJ Miller, M Roederer
Journal of immunology (Baltimore, Md. : 1950) 2004
Persistent and selective deficiency of CD4+ T cell immunity to cytomegalovirus in immunocompetent young children
W Tu, S Chen, M Sharp, C Dekker, AM Manganello, EC Tongson, HT Maecker, TH Holmes, Z Wang, G Kemble, S Adler, A Arvin, DB Lewis
Journal of immunology (Baltimore, Md. : 1950) 2004
Age-associated change in the frequency of memory CD4+ T cells impairs long term CD4+ T cell responses to influenza vaccine
I Kang, MS Hong, H Nolasco, SH Park, JM Dan, JY Choi, J Craft
Journal of immunology (Baltimore, Md. : 1950) 2004
Emergence of a CD4+CD28- granzyme B+, cytomegalovirus-specific T cell subset after recovery of primary cytomegalovirus infection
EM van Leeuwen, EB Remmerswaal, MT Vossen, AT Rowshani, PM Dillen, RA van Lier, IJ Berge
Journal of immunology (Baltimore, Md. : 1950) 2004
Functional assessment and specific depletion of alloreactive human T cells using flow cytometry
SL Martins, LS st John, RE Champlin, ED Wieder, J McMannis, JJ Molldrem, KV Komanduri
Blood 2004
High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay
MP Crawford, SX Yan, SB Ortega, RS Mehta, RE Hewitt, DA Price, P Stastny, DC Douek, RA Koup, MK Racke, NJ Karandikar
Blood 2004
Defective control of latent Epstein-Barr virus infection in systemic lupus erythematosus
I Kang, T Quan, H Nolasco, SH Park, MS Hong, J Crouch, EG Pamer, JG Howe, J Craft
Journal of immunology (Baltimore, Md. : 1950) 2004
Analysis of the CD8+ T cell response to the G1 domain of aggrecan in ankylosing spondylitis
J Zou, H Appel, M Rudwaleit, A Thiel, J Sieper
Annals of the rheumatic diseases 2004
Assessment of human cytomegalovirus specific T cell immunity in human immunodeficiency virus infected patients in different disease stages following HAART and in long-term non-progressors
A Tamarit, J Alberola, JV Mira, C Tornero, MJ Galindo, D Navarro
Journal of Medical Virology 2004
CMV antigen-specific CD4+ and CD8+ T cell IFNgamma expression and proliferation responses in healthy CMV-seropositive individuals
E Sinclair, D Black, CL Epling, A Carvidi, SZ Josefowicz, BM Bredt, MA Jacobson
Viral Immunology 2004
Cofilin peptide homologs interfere with immunological synapse formation and T cell activation
SM Eibert, KH Lee, R Pipkorn, U Sester, GH Wabnitz, T Giese, SC Meuer, Y Samstag
Proceedings of the National Academy of Sciences 2004
Investigations on four host response factors whose expression is enhanced in X4 SHIV encephalitis
S Buch, Y Sui, N Dhillon, R Potula, C Zien, D Pinson, S Li, S Dhillon, B Nicolay, A Sidelnik, C Li, T Villinger, K Bisarriya, O Narayan
Journal of Neuroimmunology 2004
Impact of vector-priming on the immunogenicity of a live recombinant Salmonella enterica serovar typhi Ty21a vaccine expressing urease A and B from Helicobacter pylori in human volunteers
WG Metzger, E Mansouri, M Kronawitter, S Diescher, M Soerensen, R Hurwitz, D Bumann, T Aebischer, BU Specht, TF Meyer
Vaccine 2004
Assessment of cellular immunity to human cytomegalovirus in recipients of allogeneic stem cell transplants
SF Lacey, DJ Diamond, JA Zaia
Biology of Blood and Marrow Transplantation 2004
Detection of antigen-specific lymphocytes/Detektion von Antigen-spezifischen Lymphozyten
A Scheffold, A Thiel
LaboratoriumsMedizin 2004
CD28 costimulation enhances the sensitivity of the ELISPOT assay for detection of antigen-specific memory effector CD4 and CD8 cell populations in human diseases
PA Ott, BR Berner, BA Herzog, R Guerkov, NL Yonkers, I Durinovic-Bello, M Tary-Lehmann, PV Lehmann, DD Anthony
Journal of Immunological Methods 2004
Cytokine flow cytometry: a multiparametric approach for assessing cellular immune responses to viral antigens
VC Maino, HT Maecker
Clinical Immunology 2004
Flow cytometric enumeration of antigen-specific T lymphocytes
JW Gratama, F Kern
Cytometry 2004
Analysis of Ehrlichia ruminantium-specific T1/T2 responses during vaccination with a protective killed vaccine and challenge of goats
I Esteves, N Vachiery, D Martinez, P Totte
Parasite Immunology 2004
CMV Antigen-Specific CD4+and CD8+T Cell IFNγ Expression and Proliferation Responses in Healthy CMV-Seropositive Individuals
E Sinclair, D Black, CL Epling, A Carvidi, SZ JosefowicZ, BM Bredt, MA Jacobson
Viral Immunology 2004
Vaccine Development to Prevent Cytomegalovirus Disease: Report from the National Vaccine Advisory Committee
JF Modlin, AM Arvin, P Fast, M Myers, S Plotkin, R Rabinovich
Clinical Infectious Diseases 2004
Editorial: Analysis of cell function in flow cytometric immunophenotyping/Editorial: Funktionelle Charakterisierung von Zellen bei der durchflusszytometrischen Immunphänotypisierung
G Rothe
LaboratoriumsMedizin 2004
HIV Type 1 Antigen-Responsive CD4+T-Lymphocytes in Exposed Yet HIV Type 1 Seronegative Ugandans
A Kebba, P Kaleebu, J Serwanga, S Rowland, D Yirrell, R Downing, J Gilmour, N Imami, F Gotch, J Whitworth
AIDS Research and Human Retroviruses 2004
T Cell Immunity to Measles Viral Proteins in Infants and Adults after Measles Immunization
HA Gans, LL Yasukawa, A Alderson, M Rinki, R Dehovitz, Y Maldonado, AM Arvin
Viral Immunology 2004
Analyzing t-cell responses to cytomegalovirus by cytokine flow cytometry
HT Maecker, VC Maino
Human Immunology 2004
Optimization of intracellular cytokine staining for the quantitation of antigen-specific CD4+ T cell responses in rhesus macaques
MC Gauduin, A Kaur, S Ahmad, T Yilma, JD Lifson, RP Johnson
Journal of Immunological Methods 2004
Optimum culture conditions for specific and nonspecific activation of whole blood and PBMC for intracellular cytokine assessment by flow cytometry
K Godoy-Ramirez, K Franck, S Mahdavifar, L Andersson, H Gaines
Journal of Immunological Methods 2004
Quantitation of dengue virus specific CD4+ T cells by intracellular cytokine staining
MM Mangada, FA Ennis, AL Rothman
Journal of Immunological Methods 2004
Novel application of a whole blood intracellular cytokine detection assay to quantitate specific T-cell frequency in field studies
WA Hanekom, J Hughes, M Mavinkurve, M Mendillo, M Watkins, H Gamieldien, SJ Gelderbloem, M Sidibana, N Mansoor, V Davids, RA Murray, A Hawkridge, PA Haslett, S Ress, GD Hussey, G Kaplan
Journal of Immunological Methods 2004
Properties of CD4(+) T cells in human cytomegalovirus infection
LE Gamadia, RJ Rentenaar, RA van Lier, IJ Berge
Human Immunology 2004
Consolidation with alemtuzumab in patients with chronic lymphocytic leukemia (CLL) in first remission – experience on safety and efficacy within a randomized multicenter phase III trial of the German CLL Study Group (GCLLSG)
CM Wendtner, M Ritgen, CD Schweighofer, G Fingerle-Rowson, H Campe, G Jäger, B Eichhorst, R Busch, H Diem, A Engert, S Stilgenbauer, H Döhner, M Kneba, B Emmerich, M Hallek
Leukemia 2004
Patterns of intracellular cytokines in CD4 and CD8 T cells from patients with mycobacterial infections
PR Antas, JS Sales, KC Pereira, EB Oliveira, KS Cunha, EN Sarno, EP Sampaio
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] 2004
Oral valganciclovir in children: single dose pharmacokinetics in a six-year-old girl:
M Burri, H Wiltshire, C Kahlert, G Wouters, C Rudin
The Pediatric Infectious Disease Journal 2004
Cancer Immunotherapy at the Crossroads
JH Finke, RM Bukowski
2004
Handbook of Cancer Vaccines
MA Morse, TM Clay, HK Lyerly
2004
Reconstitution of HLA-A*2402-Restricted Cytomegalovirus-Specific T-Cells following Stem Cell Transplantation
H Gondo, D Himeji, K Kamezaki, A Numata, T Tanimoto, K Takase, K Aoki, H Henzan, K Nagafuji, T Miyamoto, F Ishikawa, K Shimoda, S Inaba, H Tsukamoto, T Horiuchi, H Nakashima, T Otsuka, K Kato, M Kuroiwa, M Higuchi, T Shibuya, T Kamimura, K Kuzushima, T Tsurumi, Y Kanda, M Harada
International Journal of Hematology 2004
Rapid generation of combined CMV-specific CD4+ and CD8+ T-cell lines for adoptive transfer into recipients of allogeneic stem cell transplants
G Rauser, H Einsele, C Sinzger, D Wernet, G Kuntz, M Assenmacher, JD Campbell, MS Topp
Blood 2004
Age-Related Impaired Type 1 T Cell Responses to Influenza: Reduced Activation Ex Vivo, Decreased Expansion in CTL Culture In Vitro, and Blunted Response to Influenza Vaccination In Vivo in the Elderly
Y Deng, Y Jing, AE Campbell, S Gravenstein
Journal of immunology (Baltimore, Md. : 1950) 2004
Identification and in vitro expansion of CD4+ and CD8+ T cells specific for human neutrophil elastase
H Fujiwara, FE Ouriaghli, M Grube, DA Price, K Rezvani, E Gostick, G Sconocchia, J Melenhorst, N Hensel, DC Douek, AJ Barrett
Blood 2004
Beyond Help: Direct Effector Functions of Human Immunodeficiency Virus Type 1-Specific CD4 + T Cells
PJ Norris, HF Moffett, OO Yang, DE Kaufmann, MJ Clark, MM Addo, ES Rosenberg
Journal of virology 2004
TIRC7 Deficiency Causes In Vitro and In Vivo Augmentation of T and B Cell Activation and Cytokine Response
N Utku, A Boerner, A Tomschegg, F Bennai-Sanfourche, GC Bulwin, T Heinemann, J Loehler, RS Blumberg, HD Volk
Journal of immunology (Baltimore, Md. : 1950) 2004
Automation of Cytokine Flow Cytometry Assays
JF Dunne, HT Maecker
JALA (Charlottesville, Va.) 2004
II, 11. Human adaptive immunity to rotaviruses: A model of intestinal mucosal adaptive immunity.
Gonzalez AM, Jaimes MC, Rojas OL, Angel J, Greenberg HB, A Franco M
Perspectives in Medical Virology 2004
Toll-like receptor ligands modulate dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses
K Loré, MR Betts, JM Brenchley, J Kuruppu, S Khojasteh, S Perfetto, M Roederer, RA Seder, RA Koup
Journal of immunology (Baltimore, Md. : 1950) 2003
Immunity to human immunodeficiency virus (HIV) in children with chronic HIV infection receiving highly active antiretroviral therapy
A Weinberg, GB Pott
Clinical and diagnostic laboratory immunology 2003
Performance of plate-based cytokine flow cytometry with automated data analysis
MA Suni, HS Dunn, PL Orr, R Laat, E Sinclair, SA Ghanekar, BM Bredt, JF Dunne, VC Maino, HT Maecker
BMC Immunology 2003
Cellular responses to cytomegalovirus in immunosuppressed patients: circulating CD8+ T cells recognizing CMVpp65 are present but display functional impairment
M Engstrand, AK Lidehall, TH Totterman, B Herrman, BM Eriksson, O Korsgren
Clinical & Experimental Immunology 2003
Multiple relapses of human cytomegalovirus retinitis during HAART in an AIDS patient with reconstitution of CD4+ T cell count in the absence of HCMV-specific CD4+ T cell response
D Lilleri, G Piccinini, F Baldanti, E Seminari, D Galloni, G Gerna
Journal of Clinical Virology 2003
Extensive MHC class I-restricted CD8 T lymphocyte responses against various yeast genera in humans
T Heintel, F Breinig, MJ Schmitt, A Meyerhans
FEMS Immunology & Medical Microbiology 2003
Diagnostic potential of tetramer-based monitoring of cytomegalovirus-specific cd8+ t lymphocytes in allogeneic stem cell transplantation
JW Gratama, JJ Cornelissen
Clinical Immunology 2003
Detection of GAD-Reactive CD4+ Cells in So-Called “Type 1B” Diabetes
A Shimada, K Kodama, J Morimoto, Y Oikawa, J Irie, Y Nakagawa, K Matsubara, T Maruyama, T Saruta
Annals of the New York Academy of Sciences 2003
Detection of antigen-specific T cell interferon γ expression by ELISPOT and cytokine flow cytometry assays in rhesus macaques
B Pahar, J Li, T Rourke, CJ Miller, MB McChesney
Journal of Immunological Methods 2003
Human cytomegalovirus infection during pregnancy and detection of specific T cells by intracellular cytokine staining
T Fujikawa, K Numazaki, H Asanuma, H Tsutsumi
International Journal of Infectious Diseases 2003
Gradual development of the interferon-γ response of swine to porcine reproductive and respiratory syndrome virus infection or vaccination
WA Meier, J Galeota, FA Osorio, RJ Husmann, WM Schnitzlein, FA Zuckermann
Virology 2003
Beyond six colors: A new era in flow cytometry
SC de Rosa, JM Brenchley, M Roederer
Nature Medicine 2003
Evidence for Gag p24-specific CD4 T cells with reduced susceptibility to R5 HIV-1 infection in a UK cohort of HIV-exposed-seronegative subjects:
J Eyeson, D King, MJ Boaz, E Sefia, S Tomkins, A Waters, PJ Easterbrook, A Vyakarnam
AIDS 2003
Flow cytometric analysis of cytomegalovirus-specific cell-mediated immunity in the congenital infection
N Hayashi, H Kimura, T Morishima, N Tanaka, T Tsurumi, K Kuzushima
Journal of Medical Virology 2003
Frequency of human cytomegalovirus-specific T cells during pregnancy determined by intracellular cytokine staining
T Fujikawa, K Numazaki, H Asanuma, R Kudo, H Tsutsumi
Journal of Medical Virology 2003
HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages
E Izmailova, FM Bertley, Q Huang, N Makori, CJ Miller, RA Young, A Aldovini
Nature Medicine 2003
Molekularmedizinische Grundlagen von rheumatischen Erkrankungen
D Ganten, K Ruckpaul, S Gay, JR Kalden
2003
Heat Shock Proteins and Inflammation
W van Eden
2003
Cutting Edge: L-Selectin (CD62L) Expression Distinguishes Small Resting Memory CD4 + T Cells That Preferentially Respond to Recall Antigen
RL Hengel, V Thaker, MV Pavlick, JA Metcalf, G Dennis, J Yang, RA Lempicki, I Sereti, HC Lane
Journal of immunology (Baltimore, Md. : 1950) 2003
Local Cooperation Dominates Over Competition Between CD4 + T Cells of Different Antigen/MHC Specificity
RJ Creusot, LL Thomsen, JP Tite, BM Chain
Journal of immunology (Baltimore, Md. : 1950) 2003
Identification of Immunodominant Epitopes Derived from the Respiratory Syncytial Virus Fusion Protein That Are Recognized by Human CD4 T Cells
GM van Bleek, MC Poelen, R van der Most, HF Brugghe, HA Timmermans, CJ Boog, P Hoogerhout, HG Otten, CA van Els
Journal of virology 2003
Glatiramer acetate (Copaxone) therapy Induces CD8+ T cell responses in patients with Multiple Sclerosis
Nitin J. Karandikar, Michael P. Crawford, Robert B. Ratts, Jason M. Brenchley, David R. Ambrozak, Amy E. Lovett-Racke, Elliot M. Frohman, Peter Stastny, Daniel C. Douek, Richard A. Koup, Michael K. Racke
Journal of Clinical Investigation 2002
Target Organ Localization of Memory CD4+ T Cells in Patients with Chronic Beryllium Disease
Andrew P. Fontenot, Scott J. Canavera, Laia Gharavi, Lee S. Newman, Brian L. Kotzin
Journal of Clinical Investigation 2002
T Cell Receptor beta Chain Gene Usage in Endemic Pemphigus Foliaceus (Fogo Selvagem)
AK Moesta, MS Lin, LA Diaz, AA Sinha
Journal of Investigative Dermatology 2002
Primary immune responses to human CMV: a critical role for IFN-gamma-producing CD4+ T cells in protection against CMV disease
LE Gamadia, EB Remmerswaal, JF Weel, F Bemelman, RA van Lier, IJ Berge
Blood 2002
Persistent numbers of tetramer+ CD8(+) T cells, but loss of interferon-gamma+ HIV-specific T cells during progression to AIDS
S Kostense, K Vandenberghe, J Joling, DV Baarle, N Nanlohy, E Manting, F Miedema
Blood 2002
HIV antigens can induce TGF-beta(1)-producing immunoregulatory CD8+ T cells
ML Garba, CD Pilcher, AL Bingham, J Eron, JA Frelinger
Journal of immunology (Baltimore, Md. : 1950) 2002
Cytomegalovirus reactivation following allogeneic stem cell transplantation is associated with the presence of dysfunctional antigen-specific CD8+ T cells
E Ozdemir, LS st John, G Gillespie, S Rowland-Jones, RE Champlin, JJ Molldrem, KV Komanduri
Blood 2002
Epitope-specific Evolution of Human CD8 + T Cell Responses from Primary to Persistent Phases of Epstein-Barr Virus Infection
AD Hislop, NE Annels, NH Gudgeon, AM Leese, AB Rickinson
Journal of Experimental Medicine 2002
Frequencies of Virus-Specific CD4 + and CD8 + T Lymphocytes Secreting Gamma Interferon after Acute Natural Rotavirus Infection in Children and Adults
MC Jaimes, OL Rojas, AM González, I Cajiao, A Charpilienne, P Pothier, E Kohli, HB Greenberg, MA Franco, J Angel
Journal of virology 2002
Cellular methods used to evaluate the immune response in transplantation: Reinsmoen : Evaluation of immune response in transplantation
NL Reinsmoen
Tissue Antigens 2002
HIV preferentially infects HIV-specific CD4+ T cells
DC Douek, JM Brenchley, MR Betts, DR Ambrozak, BJ Hill, Y Okamoto, JP Casazza, J Kuruppu, K Kunstman, S Wolinsky, Z Grossman, M Dybul, A Oxenius, DA Price, M Connors, RA Koup
Nature 2002
CD8+T-Cell Response Against Hepatitis C Virus
XS He, HB Greenberg
Viral Immunology 2002
S antigen specific effector T cell activation detected by cytokine flow cytometry
JP Morgan, RA Robins, HS Dua, PJ Tighe
The British journal of ophthalmology 2002
Immunologic Monitoring of Cancer Vaccine Therapy: Results of a Workshop Sponsored by the Society for Biological Therapy
U Keilholz, J Weber, JH Finke, DI Gabrilovich, WM Kast, ML Disis, JM Kirkwood, C Scheibenbogen, J Schlom, VC Maino, HK Lyerly, PP Lee, W Storkus, F Marincola, A Worobec, MB Atkins
Journal of Immunotherapy 2002
Increasing CD4+T Cells Specific for Tuberculosis Correlate with Improved Clinical Immunity after Highly Active Antiretroviral Therapy
RL Hengel, MC Allende, RL Dewar, JA Metcalf, JA Mican, HC Lane
AIDS Research and Human Retroviruses 2002
Peripheral blood CD4+ and CD8+ T cell type 1 and type 2 cytokine production in atopic asthmatic and normal subjects
SH Cho, LA Stanciu, T Begishivili, PJ Bates, ST Holgate, SL Johnston
Clinical & Experimental Allergy 2002
Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine
RR Amara, F Villinger, JD Altman, SL Lydy, SP O’Neil, SI Staprans, DC Montefiori, Y Xu, JG Herndon, LS Wyatt, MA Candido, NL Kozyr, PL Earl, JM Smith, HL Ma, BD Grimm, ML Hulsey, HM McClure, JM McNicholl, B Moss, HL Robinson
Vaccine 2002
A randomized, placebo-controlled trial of subcutaneous administration of GM-CSF as a vaccine adjuvant: effect on cellular and humoral immune responses
J Somani, S Lonial, H Rosenthal, S Resnick, I Kakhniashvili, EK Waller
Vaccine 2002
Human T cells that have been conditioned by the proteolytic activity of the major dust mite allergen Der p 1 trigger enhanced immunoglobulin E synthesis by B cells
AM Ghaemmaghami, F Shakib
Clinical & Experimental Allergy 2002
The Dual Role of CD4 T Helper Cells in the Infection Dynamics of HIV and Their Importance for Vaccination
HK Altes, D Wodarz, V Jansen
Journal of Theoretical Biology 2002
Efficacy of a B virus gD DNA vaccine for induction of humoral and cellular immune responses in Japanese macaques
M Hirano, S Nakamura, F Mitsunaga, M Okada, K Shimizu, M Ueda, A Bennett, R Eberle
Vaccine 2002
CD4+T cell levels are decreased during active CMV infection in kidney transplant recipients
S Essa, AS Pacsa, R Raghupathy, R Al-Attiyah, A El-Shazly, T Said
FEMS Immunology & Medical Microbiology 2002
Multiparameter cytokine-specific affinity matrix assay for the determination of frequencies and phenotype of antigen-reactive T cells
G Mathioudakis, D Coder, A Fefer
Journal of Immunological Methods 2002
Application of a 5-bromo-2′-deoxyuridine ELISA for measuring the lymphoproliferative response to human cytomegalovirus in HIV-1-infected patients
A Tamarit, J Alberola, MJ Galindo, D Navarro
Journal of Virological Methods 2002
Methods in Cell Biology
JW Smith
Methods in cell biology 2002
Gene Therapy in Lung Disease
K Amin
Gene Therapy in Lung Disease 2002
Functional discrepancies in HIV-specific CD8+ T-lymphocyte populations are related to plasma virus load
A Oxenius, AK Sewell, SJ Dawson, HF Günthard, M Fischer, GM Gillespie, SL Rowland-Jones, C Fagard, B Hirschel, RE Phillips, DA Price,
Journal of Clinical Immunology 2002
Cytomegalovirus infections in kidney transplant patients
N Babel, F Kern, HD Volk, P Reinke
Transplantation Reviews 2002
Clinical trials with CMV-specific T cells
KS Peggs, S Mackinnon
Cytotherapy 2002
Flow cytometric quantitation and characterization of the T-lymphocyte memory response to CMV in healthy donors
N Hensel, JJ Melenhorst, K Bradstock, AP Schwarer, R Eniafe, R Nakamura, AJ Barrett
Cytotherapy 2002
Thymic function and allogeneic T-cell responses in stem-cell transplantation
KV Komanduri
Cytotherapy 2002
Impact of high-dose chemotherapy on antigen-specific T cell immunity in breast cancer patients. Application of new flow cytometric method
IM Svane, K Nikolajsen, SW Hansen, C Kamby, DL Nielsen, HE Johnsen
Bone Marrow Transplantation 2002
Frequencies of HCV-specific effector CD4+ T cells by flow cytometry: Correlation with clinical disease stages
H Rosen
Hepatology 2002
Dendritic cells cross-presenting viral antigens derived from autologous cells as a sensitive tool for visualization of human cytomegalovirus-reactive CD8+ T cells1:
MJ Raftery, M Schwab, S Diesner, G Egerer, G Schonrich
Transplantation 2002
Human Cell Culture
MR Koller, BO Palsson, JR Masters
2002
Beryllium Skin Patch Testing to Analyze T Cell Stimulation and Granulomatous Inflammation in the Lung
AP Fontenot, LA Maier, SJ Canavera, TB Hendry-Hofer, M Boguniewicz, EA Barker, LS Newman, BL Kotzin
Journal of immunology (Baltimore, Md. : 1950) 2002
Development and Homeostasis of T Cell Memory in Rhesus Macaque
CJ Pitcher, SI Hagen, JM Walker, R Lum, BL Mitchell, VC Maino, MK Axthelm, LJ Picker
Journal of immunology (Baltimore, Md. : 1950) 2002
Decreased Frequency of Cytomegalovirus (CMV)-Specific CD4 + T Lymphocytes in Simian Immunodeficiency Virus-Infected Rhesus Macaques: Inverse Relationship with CMV Viremia
A Kaur, CL Hale, B Noren, N Kassis, MA Simon, RP Johnson
Journal of virology 2002
Sensitive detection of human cytomegalovirus peptide–specific cytotoxic T-lymphocyte responses by interferon-γ–enzyme-linked immunospot assay and flow cytometry in healthy individuals and in patients after allogeneic stem cell transplantation
H Hebart, S Daginik, S Stevanovic, U Grigoleit, A Dobler, M Baur, G Rauser, C Sinzger, G Jahn, J Loeffler, L Kanz, HG Rammensee, H Einsele
Blood 2002
Infection of APC by Human Cytomegalovirus Controlled Through Recognition of Endogenous Nuclear Immediate Early Protein 1 by Specific CD4 + T Lymphocytes
EL Roy, M Baron, W Faigle, D Clément, DM Lewinsohn, DN Streblow, JA Nelson, S Amigorena, JL Davignon
Journal of immunology (Baltimore, Md. : 1950) 2002
Quantitation, selection, and functional characterization of Epstein-Barr virus–specific and alloreactive T cells detected by intracellular interferon-γ production and growth of cytotoxic precursors
G Koehne, KM Smith, TL Ferguson, RY Williams, G Heller, EG Pamer, B Dupont, RJ O'Reilly
Blood 2002
Direct Ex Vivo Analysis of Human CD4 + Memory T Cell Activation Requirements at the Single Clonotype Level
AD Bitmansour, DC Douek, VC Maino, LJ Picker
Journal of immunology (Baltimore, Md. : 1950) 2002
Detection of Intracellular Cytokines by Flow Cytometry
B Foster, C Prussin
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2002
Differentiation of cytomegalovirus-specific CD8(+) T cells in healthy and immunosuppressed virus carriers
LE Gamadia, RJ Rentenaar, PA Baars, EB Remmerswaal, S Surachno, JF Weel, M Toebes, TN Schumacher, IJ Berge, RA van Lier
Blood 2001
Identification of HLA-B27-restricted peptides from the Chlamydia trachomatis proteome with possible relevance to HLA-B27-associated diseases
W Kuon, HG Holzhütter, H Appel, M Grolms, S Kollnberger, A Traeder, P Henklein, E Weiss, A Thiel, R Lauster, P Bowness, A Radbruch, PM Kloetzel, J Sieper
Journal of immunology (Baltimore, Md. : 1950) 2001
High-level HIV-1 viremia suppresses viral antigen-specific CD4(+) T cell proliferation
AC McNeil, WL Shupert, CA Iyasere, CW Hallahan, JA Mican, RT Davey, M Connors
Proceedings of the National Academy of Sciences 2001
Multiple Effector Functions Mediated by Human Immunodeficiency Virus-Specific CD4 + T-Cell Clones
PJ Norris, M Sumaroka, C Brander, HF Moffett, SL Boswell, T Nguyen, Y Sykulev, BD Walker, ES Rosenberg
Journal of virology 2001
Current Protocols in Immunology
EH Leiter
Current Protocols in Immunology 2001
New insights into evaluating effective T-cell responses to HIV
TM Allen, DI Watkins
AIDS 2001
High frequency of circulating HBcAg-specific CD8 T cells in hepatitis B infection: a flow cytometric analysis
S Matsumura, K Yamamoto, N Shimada, N Okano, R Okamoto, T Suzuki, T Hakoda, M Mizuno, T Higashi, T Tsuji
Clinical & Experimental Immunology 2001
Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize the beta -chemokine macrophage inflammatory protein-1beta
R Kamin-Lewis, SF Abdelwahab, C Trang, A Baker, AL DeVico, RC Gallo, GK Lewis
Proceedings of the National Academy of Sciences 2001
Lack of evidence for the Th2 predominance in patients with chronic hepatitis C
A Bergamini, F Bolacchi, G Cerasari, C Carvelli, E Faggioli, M Cepparulo, F Demin, I Uccella, B Bongiovanni, P Niutta, M Capozzi, M Lupi, E Piscitelli, G Rocchi, M Angelico
Clinical & Experimental Immunology 2001
Interferon-gamma administration after abdominal surgery rescues antigen-specific helper T cell immune reactivity
RJ Rentenaar, J Metz, M Bunders, PM Dillen, DJ Gouma, JA Romijn, HP Sauerwein, IJ Berge, RA van Lier
Clinical & Experimental Immunology 2001
In vitro hydroxyurea decreases Th1 cell-mediated immunity
A Weinberg
Clinical and diagnostic laboratory immunology 2001
CMVR diagnoses and progression of CD4 cell counts and HIV viral load measurements in HIV patients on HAART
HJ Zambarakji, RB Newson, SM Mitchell
The British journal of ophthalmology 2001
Expression of perforin on HIV-1-specific CD8+ lymphocytes after immunization with a gp120-depleted, whole-killed HIV-1 immunogen
RB Moss, WK Giermakowska, MR Wallace, FC Jensen, RZ Maigetter, DJ Carlo
Clinical & Experimental Immunology 2001
Detection and quantification of HIV-1 specific CD4 helper and CD8 cytotoxic cells: their role in HIV-1-infected individuals and vaccine recipients
N Imami, G Hardy, A Pires, C Burton, A Sullivan, F Gotch
HIV Medicine 2001
Cell function-based flow cytometry
JJ Bleesing, TA Fleisher
Seminars in Hematology 2001
Quantitative Analysis of Adenovirus-Specific CD4+T-Cell Responses from Healthy Adults
M Olive, LC Eisenlohr, P Flomenberg
Viral Immunology 2001
Analysis of the antigen specific T cell repertoires in HIV infection
GL Pira, L Bottone, D Fenoglio, P Terranova, E Pontali, F Ivaldi, FD Galdo, L Mortara, A Loregian, G Palù, A Kunkl, R Accolla, RD Palma, F Manca
Immunology Letters 2001
Quantitative analysis of specific Th1/Th2 helper cell responses and IgG subtype antibodies in interferon-?-treated patients with chronic hepatitis C
G Hempel, PR Galle, HF L�hr
Journal of Medical Virology 2001
Insights into the Specificity and Function of (Allo)antigen-reactive T Cells
HD Volk, F Kern
American Journal of Transplantation 2001
Human T cell subset commitment determined by the intrinsic property of antigen: the proteolytic activity of the major mite allergen Der p 1 conditions T cells to produce more IL-4 and less IFN-γ
AM Ghaemmaghami, A Robins, L Gough, HF Sewell, F Shakib
European Journal of Immunology 2001
Sustained Cytomegalovirus-Specific CD4+T Cell Response Associated with Prevention of Recurrence of Cytomegalovirus Retinitis without Secondary Prophylaxis after Highly Active Antiretroviral Therapy in Patients with AIDS
M Tanaka, C Yasuoka, I Genka, N Tachikawa, Y Kikuchi, K Teruya, A Yasuoka, Y Hirabayashi, S Kimura, S Oka
AIDS Research and Human Retroviruses 2001
Direct Functional Analysis of Epitope-Specific CD8+T Cells in Peripheral Blood
XS He, B Rehermann, J Boisvert, J Mumm, HT Maecker, M Roederer, TL Wright, VC Maino, MM Davis, HB Greenberg
Viral Immunology 2001
Routine detection of Epstein–Barr virus specific T-cells in the peripheral blood by flow cytometry
BE Crucian, RP Stowe, DL Pierson, CF Sams
Journal of Immunological Methods 2001
Ex vivo analysis of tumor antigen specific CD8+ T cell responses using MHC/peptide tetramers in cancer patients
MJ Pittet, DE Speiser, D Valmori, D Rimoldi, D Liénard, F Lejeune, JC Cerottini, P Romero
International Immunopharmacology 2001
Direct Measurement of CD4+ and CD8+ T-Cell Responses to CMV in HIV-1-Infected Subjects
KV Komanduri, SM Donahoe, WJ Moretto, DK Schmidt, G Gillespie, GS Ogg, M Roederer, DF Nixon, JM McCune
Virology 2001
Potential clinical utility of monitoring cytomegalovirus-specific T lymphocytes in allogeneic stem cell transplantation
JW Gratama, JJ Cornelissen
Clinical and Applied Immunology Reviews 2001
Longitudinal analysis of T-cell receptor gene use by CD8(+) T cells in early human immunodeficiency virus infection in patients receiving highly active antiretroviral therapy
AM Schito, E Vittinghoff, FM Hecht, MK Elkins, JO Kahn, JA Levy, JR Oksenberg
Blood 2001
Direct detection of cellular immune responses to cancer vaccines
PJ Mosca, AC Hobeika, TM Clay, MA Morse, HK Lyerly
Surgery 2001
Detection of allospecific T cells by intracellular cytokine staining and flowcytometry
RJ Rentenaar, JL Vosters, RA Lier, IJ Berge
Transplantation Proceedings 2001
Use of overlapping peptide mixtures as antigens for cytokine flow cytometry
H T Maecker, H S Dunn, M A Suni, E Khatamzas, C J Pitcher, T Bunde, N Persaud, W Trigona, T M Fu, E Sinclair, B M Bredt, J M McCune, V C Maino, F Kern, L J Picker
Journal of Immunological Methods 2001
Genetically modified immunocompetent cells in HIV infection
G Palù, GL Pira, F Gennari, D Fenoglio, C Parolin, F Manca
Gene Therapy 2001
Interdisziplinäre klinische Rheumatologie
H Zeidler, J Zacher, F Hiepe
2001
Functional Heterogeneity of Cytokines and Cytolytic Effector Molecules in Human CD8 + T Lymphocytes
JK Sandberg, NM Fast, DF Nixon
Journal of immunology (Baltimore, Md. : 1950) 2001
Comparative Analysis of Human Cytomegalovirus-Specific CD4 + T-Cell Frequency and Lymphoproliferative Response in Human Immunodeficiency Virus-Positive Patients
G Piccinini, G Comolli, E Genini, D Lilleri, R Gulminetti, R Maccario, MG Revello, G Gerna
Clinical and diagnostic laboratory immunology 2001
Tetramer-based quantification of cytomegalovirus (CMV)–specific CD8+ T lymphocytes in T-cell–depleted stem cell grafts and after transplantation may identify patients at risk for progressive CMV infection
JW Gratama, JW van Esser, CH Lamers, C Tournay, B Löwenberg, RL Bolhuis, JJ Cornelissen
Blood 2001
Ex Vivo Stimulation and Expansion of both CD4 + and CD8 + T Cells from Peripheral Blood Mononuclear Cells of Human Cytomegalovirus-Seropositive Blood Donors by Using a Soluble Recombinant Chimeric Protein, IE1-pp65
J Vaz-Santiago, J Lulé, P Rohrlich, C Jacquier, N Gibert, EL Roy, D Betbeder, JL Davignon, C Davrinche
Journal of virology 2001
Gamma Interferon Expression in CD8 + T Cells Is a Marker for Circulating Cytotoxic T Lymphocytes That Recognize an HLA A2-Restricted Epitope of Human Cytomegalovirus Phosphoprotein pp65
SA Ghanekar, LE Nomura, MA Suni, LJ Picker, HT Maecker, VC Maino
Clinical and diagnostic laboratory immunology 2001
EBV-Specific CD8 + T Cell Memory: Relationships Between Epitope Specificity, Cell Phenotype, and Immediate Effector Function
AD Hislop, NH Gudgeon, MF Callan, C Fazou, H Hasegawa, M Salmon, AB Rickinson
Journal of immunology (Baltimore, Md. : 1950) 2001
Clonotypic Structure of the Human CD4 + Memory T Cell Response to Cytomegalovirus
AD Bitmansour, SL Waldrop, CJ Pitcher, E Khatamzas, F Kern, VC Maino, LJ Picker
Journal of immunology (Baltimore, Md. : 1950) 2001
Ex Vivo IFN-γ Secretion by Circulating CD8 T Lymphocytes: Implications of a Novel Approach for T Cell Monitoring in Infectious and Malignant Diseases
MJ Pittet, A Zippelius, DE Speiser, M Assenmacher, P Guillaume, D Valmori, D Liénard, F Lejeune, JC Cerottini, P Romero
Journal of immunology (Baltimore, Md. : 1950) 2001
Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine
RR Amara, F Villinger, JD Altman, SL Lydy, SP O'Neil, SI Staprans, DC Montefiori, Y Xu, JG Herndon, LS Wyatt, MA Candido, NL Kozyr, PL Earl, JM Smith, HL Ma, BD Grimm, ML Hulsey, J Miller, HM McClure, JM McNicholl, B Moss, HL Robinson
Science 2001
Development of virus-specific CD4+ T cells during primary cytomegalovirus infection
RJ Rentenaar, LE Gamadia, N DerHoek, FN van Diepen, R Boom, JF Weel, PM Dillen, RA van Lier, IJ Berge
Journal of Clinical Investigation 2000
Durchflußzytometrie in der Klinischen Diagnostik. Positionspapier der Arbeitsgruppe Durchflußzytometrie und Quantitative Mikroskopie der Deutschen Gesellschaft für Klinische Chemie und Deutschen Gesellschaft für Laboratoriumsmedizin
U Sack, G Rothe, S Barlage, R Gruber, D Kabelitz, TO Kleine, A Lun, H Renz, A Ruf, G Schmitz
LaboratoriumsMedizin 2000
Parameters Influencing Measurement of the Gag Antigen-Specific T-Proliferative Response to HIV Type 1 Infection
DS Schiller, JM Binley, KH Roux, CS Adamson, IM Jones, HG Krausslich, A Hurley, M Markowitz, JP Moore
AIDS Research and Human Retroviruses 2000
Flow cytometric analysis of peptide binding to major histocampatibility complex class I for hepatitis C virus core T-cell epitopes
S Schweitzer, AM Schneiders, B Langhans, W Kraas, G Jung, O Vidalin, G Inchauspe, T Sauerbruch, U Spengler
Cytometry 2000
Longitudinal Changes in CD4+T Cell Antigen Receptor Diversity and Naive/Memory Cell Phenotype during 9 to 26 Months of Antiretroviral Therapy of HIV-Infected Patients
JC Gea-Banacloche, L Martino, JM Mican, CW Hallahan, M Baseler, R Stevens, L Lambert, M Polis, HC Lane, M Connors
AIDS Research and Human Retroviruses 2000
Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapy
S Fleury, GP Rizzardi, A Chapuis, G Tambussi, C Knabenhans, E Simeoni, JY Meuwly, JM Corpataux, A Lazzarin, F Miedema, G Pantaleo
Proceedings of the National Academy of Sciences 2000
Monitoring of antigen-specific cytolytic T lymphocytes in cancer patients receiving immunotherapy
TL Whiteside
Clinical and diagnostic laboratory immunology 2000
Quantification of the number of cytotoxic T cells specific for an immunodominant HCV-specific CTL epitope primed by DNA immunization
AY Lee, NK Polakos, GR Otten, JB Ulmer, M Houghton, X Paliard
Vaccine 2000
Enhancement of HIV Type 1 Antigen-Specific CD4+T Cell Memory in Subjects with Chronic HIV Type 1 Infection Receiving an HIV Type 1 Immunogen
VC Maino, MA Suni, SB Wormsley, DJ Carlo, MA Wallace, RB Moss
AIDS Research and Human Retroviruses 2000
CD30 expression on circulating memory CD4+T cells as a Th2-dominated situation in patients with atopic dermatitis
J Yamamoto, Y Adachi, Y Onoue, H Kanegane, T Miyawaki, M Toyoda, T Seki, M Morohashi
Allergy 2000
Complex cytokine responses to hepatitis B surface antigen and tetanus toxoid in responders, nonresponders and subjects naive to hepatitis B surface antigen
CE Larsen, J Xu, S Lee, DP Dubey, G Uko, EJ Yunis, CA Alper
Vaccine 2000
Mistaken self, a novel model that links microbial infections with myelin-directed autoimmunity in multiple sclerosis
JM van Noort, JJ Bajramovic, AC Plomp, MJ van Stipdonk
Journal of Neuroimmunology 2000
Effect of Cryopreservation on Measurement of Cytomegalovirus-Specific Cellular Immune Responses in HIV-Infected Patients
A Weinberg, DA Wohl, DG Brown, GB Pott, L Zhang, MG Ray, C der Horst
JAIDS Journal of Acquired Immune Deficiency Syndromes 2000
Flow cytometric visualisation of cytokine production by CD3-CD56+ NK cells and CD3+CD56+ NK-T cells in whole blood
R Mendes, KV Bromelow, M Westby, J Galea-Lauri, IE Smith, ME O'Brien, BE Souberbielle
Cytometry 2000
Optimization of whole blood antigen-specific cytokine assays for CD4+ T cells
LE Nomura, JM Walker, HT Maecker
Cytometry 2000
Assessment of donor T-cell function in cellular blood components by the CD69 induction assay: effects of storage, gamma radiation, and photochemical treatment
E Fiebig, DF Hirschkorn, VC Maino, JA Grass, L Lin, MP Busch
Transfusion 2000
Antigen-Dependent Cytokine mRNA Expression by Individual Rhesus Macaque T Helper Cells by Flow Cytometry
J Arredondo, FX Lü, F Villinger, MB McChesney, JR McGhee, CJ Miller
Cellular Immunology 2000
Analysis of the antigen-specific T cell response in reactive arthritis by flow cytometry
A Thiel, P Wu, R Lauster, J Braun, A Radbruch, J Sieper
Arthritis & Rheumatism 2000
The CD4+ T cell response to HIV-1
LJ Picker, VC Maino
Current Opinion in Immunology 2000
Intratumoral Administration of Adenoviral Interleukin 7 Gene-Modified Dendritic Cells Augments Specific Antitumor Immunity and Achieves Tumor Eradication
PW Miller, S Sharma, M Stolina, LH Butterfield, J Luo, Y Lin, M Dohadwala, RK Batra, L Wu, JS Economou, SM Dubinett
Human Gene Therapy 2000
Progressive Reduction of CMV-Specific CD4+ T Cells in HIV-1 Infected Individuals During Antiretroviral Therapy
V Grosse, A Schulte, K Weber, M Mendila, R Jacobs, RE Schmidt, H Heiken
Immunobiology 2000
Direct Measurement of CD8+ T Cell Responses in Macaques Infected with Simian Immunodeficiency Virus
SM Donahoe, WJ Moretto, RV Samuel, KJ Metzner, PA Marx, T Hanke, RI Connor, DF Nixon
Virology 2000
Immunological benefits of antiretroviral therapy in very early stages of asymptomatic chronic HIV-1 infection
M Plana, F García, T Gallart, C Tortajada, A Soriano, E Palou, MJ Maleno, JJ Barceló, C Vidal, A Cruceta, JM Miró, JM Gatell
AIDS 2000
Tumor Antigens in Thoracic Malignancy
SM Dubinett, RK Batra, PW Miller, S Sharma
American journal of respiratory cell and molecular biology 2000
A novel sensitive approach for frequency analysis of measles virus-specific memory T-lymphocytes in healthy adults with a childhood history of natural measles
S Niewiesk, A Rauch, HW Kreth, E Kämpgen, R Nanan
Journal of General Virology 2000
Rapid whole blood analysis of virus-specific CD4 and CD8 T cell responses in persistent HIV infection:
M Sester, U Sester, H Köhler, T Schneider, L Deml, R Wagner, N Mueller-Lantzsch, HW Pees, A Meyerhans
AIDS 2000
Reconstitution of lymphocyte subpopulations after paediatric bone marrow transplantation
E Vries, MJ Tol, RL Bergh, JL Waaijer, MM Dam, J Hermans, JM Vossen
Bone Marrow Transplantation 2000
Status of Cytomegalovirus Prevention and Treatment in 2000
JA Zaia, JG Sissons, S Riddell, DJ Diamond, MR Wills, AJ Carmichael, MP Weekes, M Gandhi, CL Rosa, M Villacres, S Lacey, S Markel, J Sun
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2000
Single-Cytokine-Producing CD4 Memory Cells Predominate in Type 1 and Type 2 Immunity
AY Karulin, MD Hesse, M Tary-Lehmann, PV Lehmann
Journal of immunology (Baltimore, Md. : 1950) 2000
B Lymphoblastoid Cell Lines as Efficient APC to Elicit CD8 + T Cell Responses Against a Cytomegalovirus Antigen
Q Sun, RL Burton, LJ Dai, WJ Britt, KG Lucas
Journal of immunology (Baltimore, Md. : 1950) 2000
HIV Gag mRNA Transfection of Dendritic Cells (DC) Delivers Encoded Antigen to MHC Class I and II Molecules, Causes DC Maturation, and Induces a Potent Human In Vitro Primary Immune Response
D Weissman, H Ni, D Scales, A Dude, J Capodici, K McGibney, A Abdool, SN Isaacs, G Cannon, K Karikó
Journal of immunology (Baltimore, Md. : 1950) 2000
Multispecific CD4 + T Cell Response to a Single 12-mer Epitope of the Immunodominant Heat-Shock Protein 60 of Yersinia enterocolitica in Yersinia -Triggered Reactive Arthritis: Overlap with the B27-Restricted CD8 Epitope, Functional Properties, and Epitope Presentation by Multiple DR Alleles
AK Mertz, P Wu, T Sturniolo, D Stoll, M Rudwaleit, R Lauster, J Braun, J Sieper
Journal of immunology (Baltimore, Md. : 1950) 2000
CD3ζ and CD28 down-modulation on CD8 T cells during viral infection
LA Trimble, LW Kam, RS Friedman, Z Xu, J Lieberman
Blood 2000
Human Immunodeficiency Virus-Specific Circulating CD8 T Lymphocytes Have Down-Modulated CD3ζ and CD28, Key Signaling Molecules for T-Cell Activation
LA Trimble, P Shankar, M Patterson, JP Daily, J Lieberman
Journal of virology 2000
Tumor-specific recognition of human myeloma cells by idiotype-induced CD8+ T cells
Y Li, M Bendandi, Y Deng, C Dunbar, N Munshi, S Jagannath, LW Kwak, HK Lyerly
Blood 2000
Human Immunodeficiency Virus Type 1 Envelope Epitope-Specific CD4 + T Lymphocytes in Simian/Human Immunodeficiency Virus-Infected and Vaccinated Rhesus Monkeys Detected Using a Peptide-Major Histocompatibility Complex Class II Tetramer
MJ Kuroda, JE Schmitz, C Lekutis, CE Nickerson, MA Lifton, G Franchini, JM Harouse, C Cheng-Mayer, NL Letvin
Journal of virology 2000
Detection and Quantification of CD4 + T Cells with Specificity for a New Major Histocompatibility Complex Class II-Restricted Influenza A Virus Matrix Protein Epitope in Peripheral Blood of Influenza Patients
T Linnemann, G Jung, P Walden
Journal of virology 2000
Immunofluorescence analysis of T-cell responses in health and disease
H T Maecker, V C Maino, L J Picker
Journal of Clinical Immunology 2000
Recent developments in flow cytometry
A Scheffold, F Kern
Journal of Clinical Immunology 2000
Increased frequency of antigen-specific CD8+ cytotoxic T lymphocytes infiltrating an Epstein-Barr virus–associated gastric carcinoma
K Kuzushima, S Nakamura, T Nakamura, Y Yamamura, N Yokoyama, M Fujita, T Kiyono, T Tsurumi
Journal of Clinical Investigation 1999
Major peptide autoepitopes for nucleosome-specific T cells of human lupus
L Lu, A Kaliyaperumal, DT Boumpas, SK Datta
Journal of Clinical Investigation 1999
Lymphocyte Proliferation Assays May Underestimate Antigen Responsiveness in Human Immunodeficiency Virus Infection
AH Patki, SF Purvis, HJ Meyerson, MM Lederman
Clinical Immunology 1999
Cytomegalovirus retinitis after the initiation of highly active antiretroviral therapy: a 2 year prospective study
SM Mitchell, WL Membrey, MS Youle, A Obi, S Worrell, BG Gazzard
The British journal of ophthalmology 1999
Frequency and characterization of antigen-specific IL-4– and IL-13– producing basophils and T cells in peripheral blood of healthy and asthmatic subjects
G Devouassoux, B Foster, LM Scott, DD Metcalfe, C Prussin
Journal of Allergy and Clinical Immunology 1999
HAART in HIV-infected patients: restoration of antigen-specific CD4 T-cell responses in vitro is correlated with CD4 memory T-cell reconstitution, whereas improvement in delayed type hypersensitivity is related to a decrease in viraemia
T Wendland, H Furrer, PL Vernazza, K Frutig, A Christen, L Matter, R Malinverni, WJ Pichler
AIDS 1999
Antigen-specific cytokine response to hepatitis C virus core epitopes in HIV/hepatitis C virus-coinfected patients
RP Woitas, JK Rockstroh, Beier, G Jung, B Kochan, B Matz, HH Brackmann, T Sauerbruch, U Spengler
AIDS 1999
Mechanisms of human cytomegalovirus (HCMV) (re)activation and its impact on organ transplant patients
P Reinke, S Prosch, F Kern, HD Volk
Transplant Infectious Disease 1999
Enrichment and detection of live antigen-specific CD4+ and CD8+ T cells based on cytokine secretion
H Brosterhus, S Brings, H Leyendeckers, RA Manz, S Miltenyi, A Radbruch, M Assenmacher, J Schmitz
European Journal of Immunology 1999
Donor cell induced CD69 expression and intracellular IL-2 and IL-4 production by peripheral blood lymphocytes isolated from kidney transplant recipients
TG Paglieroni, R Perez, S Katznelson, K Muto, T Chang, S Scott, MR MacKenzie, PV Holland
Human Immunology 1999
Flow cytometric detection of antigen-specific cytokine responses in lung T cells in a murine model of pulmonary inflammation
GE Winterrowd, JE Chin
Journal of Immunological Methods 1999
HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression
CJ Pitcher, C Quittner, DM Peterson, M Connors, RA Koup, VC Maino, LJ Picker
Nature Medicine 1999
Interleukin-4 Diminishes CD8 + Respiratory Syncytial Virus-Specific Cytotoxic T-Lymphocyte Activity In Vivo
S Aung, YW Tang, BS Graham
Journal of virology 1999
Rapid Determination of Epstein-Barr Virus–Specific CD8+T-Cell Frequencies by Flow Cytometry
K Kuzushima, Y Hoshino, K Fujii, N Yokoyama, M Fujita, T Kiyono, H Kimura, T Morishima, Y Morishima, T Tsurumi
Blood 1999
CMV Retinitis and the Controversies Associated with Highly Active Antiretroviral Therapy and the Immune Recovery Hypothesis
JB Reed, LS Morse
AIDS Patient Care and STDs 1998
Restoration of cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and highly active antiretroviral therapy in individuals infected with HIV-1
KV Komanduri, MN Viswanathan, ED Wieder, DK Schmidt, BM Bredt, MA Jacobson, JM McCune
Nature Medicine 1998
Single-cell analysis of lymphokine imbalance in asymptomatic HIV-1 infection: evidence for a major alteration within the CD8+ T cell subset
AE Sousa, RM Victorino
Clinical & Experimental Immunology 1998
Multiple modes of cellular activation and virus transmission in HIV infection: a role for chronically and latently infected cells in sustaining viral replication
Z Grossman, MB Feinberg, WE Paul
Proceedings of the National Academy of Sciences 1998
Dual effect of interleukin 4 on HIV-1 expression: implications for viral phenotypic switch and disease progression
A Valentin, W Lu, M Rosati, R Schneider, J Albert, A Karlsson, GN Pavlakis
Proceedings of the National Academy of Sciences 1998
Cytomegalovirus-specific IFNγ and IL-4 are produced by antigen expanded human blood lymphocytes from seropositive volunteers
EG Kallas, K Reynolds, J Andrews, T Fitzgerald, M Kasper, M Menegus, TG Evans
Immunology Letters 1998
T-cell epitope mapping by flow cytometry
F Kern, IP Surel, C Brock, B Freistedt, H Radtke, A Scheffold, R Blasczyk, P Reinke, J Schneider-Mergener, A Radbruch, P Walden, HD Volk
Nature Medicine 1998
Ocular Manifestations of HIV Infection
ET Cunningham, TP Margolis
New England Journal of Medicine 1998
Prevention of Acute Allograft Rejection by Antibody Targeting of TIRC7, a Novel T Cell Membrane Protein
N Utku, T Heinemann, SG Tullius, GC Bulwin, S Beinke, RS Blumberg, F Beato, J Randall, R Kojima, L Busconi, ES Robertson, R Schülein, HD Volk, EL Milford, SR Gullans
Immunity 1998
Lack of T-cell proliferative response to HIV-1 antigens after 1 year of highly active antiretroviral treatment in early HIV-1 disease
M Plana, F Garcia, T Gallart, JM Miró, JM Gatell
The Lancet 1998
Detection of antigen-specific T cell cytokine expression in whole blood by flow cytometry
MA Suni, LJ Picker, VC Maino
Journal of Immunological Methods 1998
Rapid assessment of antigen induced cytokine expression in memory T cells by flow cytometry
VC Maino
Veterinary Immunology and Immunopathology 1998
Dual effect of interleukin 4 on HIV-1 expression: Implications for viral phenotypic switch and disease progression
A Valentin, W Lu, M Rosati, R Schneider, J Albert, A Karlsson, GN Pavlakis
Proceedings of the National Academy of Sciences 1998
Multiple modes of cellular activation and virus transmission in HIV infection: A role for chronically and latently infected cells in sustaining viral replication
Z Grossman, MB Feinberg, WE Paul
Proceedings of the National Academy of Sciences 1998
Novel methods to monitor antigen-specific cytotoxic T-cell responses in cancer immunotherapy
P Romero, JC Cerottini, GA Waanders
Molecular Medicine Today 1998
Intestinal Intraepithelial Lymphocytes Are Primed for Gamma Interferon and MIP-1β Expression and Display Antiviral Cytotoxic Activity despite Severe CD4 + T-Cell Depletion in Primary Simian Immunodeficiency Virus Infection
JJ Mattapallil, Z Smit-McBride, M McChesney, S Dandekar
Journal of virology 1998
Simultaneous detection of DNA synthesis and cytokine production in staphylococcal enterotoxin B activated CD4+ T lymphocytes by flow cytometry
BA Mehta, VC Maino
Journal of Immunological Methods 1997

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