The highly regulated secretion of effector cytokines by CD4+ T cells plays a critical role in immune protection against pathogens such as cytomegalovirus. Here, we directly compare the frequency and functional characteristics of cytomegalovirus-specific CD4+ memory/effector T cells in normal and HIV+ subjects using a novel, highly efficient multiparameter flow cytometric assay that detects the rapid intracellular accumulation of cytokine(s) after short-term (6 h) in vitro antigen stimulation. Responses in this assay correlate precisely with independent measures of sensitization history (e.g., seroreactivity), and allow the simultaneous assessment of multiple cytokines in single effector T cells. Healthy HIV- individuals manifested an average of 0.71, 0.72, 0.38, and 0.06% CD4+ T cells responding to cytomegalovirus with gamma-IFN, TNF-alpha, IL-2, and IL-4 production, respectively, with the simultaneous production of gamma-IFN, TNF-alpha, and IL-2 being the most common effector phenotype. Significantly, overall cytomegalovirus-specific CD4+ effector frequencies were markedly higher among 40% of HIV+ subjects (2.7-8.0%), and demonstrated a predominately polarized gamma-IFN+/TNF-alpha+/IL-2-/IL-4- phenotype. In contrast, CD4+ effector frequencies for heterologous, nonubiquitous viruses such as the mumps virus were low or absent in the HIV+ group. These data suggest the existence of homeostatic mechanisms in HIV disease that selectively preserve memory T cell populations reactive with ubiquitous pathogens such as cytomegalovirus-likely at the expense of T cell memory to more sporadically encountered infectious agents.
S L Waldrop, C J Pitcher, D M Peterson, V C Maino, L J Picker
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Herpes simplex virus type 2 tegument proteins contain subdominant T-cell epitopes detectable in BALB/c mice after DNA immunization and infection
WJ Muller, L Dong, A Vilalta, B Byrd, KM Wilhelm, CL McClurkan, M Margalith, C Liu, D Kaslow, J Sidney, A Sette, DM Koelle |
Journal of General Virology | 2009 |
Human Late Memory CD8 + T Cells Have a Distinct Cytokine Signature Characterized by CC Chemokine Production without IL-2 Production
TK Kim, LS John, ED Wieder, J Khalili, Q Ma, KV Komanduri |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
CD4 T-Cell-Mediated Heterologous Immunity between Mycobacteria and Poxviruses
KS Mathurin, GW Martens, H Kornfeld, RM Welsh |
Journal of virology | 2009 |
Preemptive Therapy for Systemic and Pulmonary Human Cytomegalovirus Infection in Lung Transplant Recipients
G Gerna, D Lilleri, V Rognoni, M Agozzino, F Meloni, T Oggionni, C Pellegrini, E Arbustini, AM D'Armini |
American Journal of Transplantation | 2009 |
T-box-expressed-in-T-cells (T-bet) expression by the tumor cells of hairy cell leukemia correlates with interferon-gammaproduction
K Jöhrens, K Jöhrens, V Moos, T Schneider, I Anagnostopoulos, K Jöhrens, V Moos, T Schneider, I Anagnostopoulos |
Leukemia & Lymphoma | 2009 |
A culture amplified multi-parametric intracellular cytokine assay (CAMP-ICC) for enhanced detection of antigen specific T-cell responses
CM Munier, JJ Zaunders, S Ip, DA Cooper, AD Kelleher |
Journal of Immunological Methods | 2009 |
War and Peace between Microbes: HIV-1 Interactions with Coinfecting Viruses
A Lisco, C Vanpouille, L Margolis |
Cell Host & Microbe | 2009 |
In vitro end points for the assessment of cellular immune response-modulating drugs
MP Fuggetta, G Lanzilli, D Fioretti, M Rinaldi |
Expert Opinion on Drug Discovery | 2009 |
Cytomegalovirus infection and disease in the new era of immunosuppression following solid organ transplantation
RA Fisher |
Transplant Infectious Disease | 2009 |
HIV-1 Tat Addresses Dendritic Cells to Induce a Predominant Th1-Type Adaptive Immune Response That Appears Prevalent in the Asymptomatic Stage of Infection
E Fanales-Belasio, S Moretti, V Fiorelli, A Tripiciano, MR Cossut, A Scoglio, B Collacchi, F Nappi, I Macchia, S Bellino, V Francavilla, A Caputo, G Barillari, M Magnani, ME Laguardia, A Cafaro, F Titti, P Monini, F Ensoli, B Ensoli |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
Human cytomegalovirus infection induces a rapid and sustained change in the expression of NK cell receptors on CD8+ T cells
A Stijn, AT Rowshani, SL Yong, F Baas, E Roosnek, IJ Berge, RA van Lier |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
Serial Assessment of Immune Status by Circulating CD8+ Effector T Cell Frequencies for Posttransplant Infectious Complications
S Uemoto, K Ozawa, H Egawa, Y Takada, H Sato, S Teramukai, M Kasahara, K Ogawa, M Ono, K Takai, M Fukushima, K Inaba, K Tanaka |
Clinical and Developmental Immunology | 2008 |
Impact of preexisting circulating effector T cells on the outcome of ABO-incompatible adult LDLT
H Egawa, K Ozawa, Y Takada, S Teramukai, A Mori, M Kasahara, K Ogawa, Y Ogura, F Oike, T Kaido, M Ono, H Sato, K Takai, S Uemoto |
Digestive Diseases and Sciences | 2008 |
Early Depletion ofMycobacterium tuberculosis–Specific T Helper 1 Cell Responses after HIV‐1 Infection
C Geldmacher, A Schuetz, N Ngwenyama, JP Casazza, E Sanga, E Saathoff, C Boehme, S Geis, L Maboko, M Singh, F Minja, A Meyerhans, RA Koup, M Hoelscher |
The Journal of Infectious Diseases | 2008 |
A fingerprint left by cytomegalovirus infection in the human T cell compartment
PJ van de Berg, A Stijn, IJ Berge, RA van Lier |
Journal of Clinical Virology | 2008 |
Intestinal double-positive CD4+CD8+ T cells of neonatal rhesus macaques are proliferating, activated memory cells and primary targets for SIVMAC251 infection
X Wang, A Das, AA Lackner, RS Veazey, B Pahar |
Blood | 2008 |
Immune responses to mumps vaccine in adults who were vaccinated in childhood
R Hanna-Wakim, LL Yasukawa, P Sung, AM Arvin, HA Gans |
The Journal of Infectious Diseases | 2008 |
Precision and linearity targets for validation of an IFNgamma ELISPOT, cytokine flow cytometry, and tetramer assay using CMV peptides
HT Maecker, J Hassler, JK Payne, A Summers, K Comatas, M Ghanayem, MA Morse, TM Clay, HK Lyerly, S Bhatia, SA Ghanekar, VC Maino, C Delarosa, ML Disis |
BMC Immunology | 2008 |
S-antigen specific T helper type 1 response is present in Behcet's disease
C Zhao, P Yang, H He, X Lin, B Li, H Zhou, X Huang, A Kijlstra |
Molecular vision | 2008 |
Computational prediction and identification of dengue virus-specific CD4+ T-cell epitopes
JS Wen, LF Jiang, JM Zhou, HJ Yan, DY Fang |
Virus Research | 2008 |
Generation of specific effector and memory T cells with gut- and secondary lymphoid tissue- homing potential by oral attenuated CVD 909 typhoid vaccine in humans
R Wahid, R Salerno-Gonçalves, CO Tacket, MM Levine, MB Sztein |
Mucosal Immunology | 2008 |
Dissection of the CMV specific T-cell response is required for optimized cardiac transplant monitoring
A Kirchner, B Hoffmeister, G Cherepnev-G, S Fuhrmann, M Streitz, R Lachmann, T Bunde, P Meij, C Schönemann, R Hetzer, HB Lehmkuhl, R Volkmer-Engert, HD Volk, JW Gratama, F Kern |
Journal of Medical Virology | 2008 |
Human cytomegalovirus load measurement and its applications for pre-emptive therapy in patients undergoing hematopoietic stem cell transplantation
F Baldanti, D Lilleri, G Gerna |
Hematological Oncology | 2008 |
Monitoring human cytomegalovirus infection in transplant recipients
F Baldanti, D Lilleri, G Gerna |
Journal of Clinical Virology | 2008 |
CMV-specific T cell therapy
H Einsele, M Kapp, GU Grigoleit |
Blood Cells, Molecules, and Diseases | 2008 |
Dysregulated expression of T-helper cell responses and susceptibility to infections in high-risk liver transplant recipients
HY Sun, N Singh, TV Cacciarelli, C Wannstedt, MM Wagener, C Steele |
Transplant Immunology | 2008 |
Cancer Immunology
OJ Finn |
New England Journal of Medicine | 2008 |
Rapid identification and sorting of viable virus-reactive CD4+ and CD8+ T cells based on antigen-triggered CD137 expression
TC Wehler, M Karg, E Distler, A Konur, M Nonn, RG Meyer, C Huber, UF Hartwig, W Herr |
Journal of Immunological Methods | 2008 |
CD4 + T Cell Responses to Cytomegalovirus in Early Life: A Prospective Birth Cohort Study
DJ Miles, M Sande, S Kaye, S Crozier, O Ojuola, MS Palmero, M Sanneh, ES Touray, P Waight, S Rowland‐Jones, H Whittle, A Marchant |
The Journal of Infectious Diseases | 2008 |
Impairment of cytomegalovirus-specific cellular immune response as a risk factor for cytomegalovirus disease in transplant recipients
VN Motta, SL Martins |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] | 2008 |
Human Cytomegalovirus
TE Shenk, MF Stinski |
2008 | |
Association between the HLA haplotype and the TCR-Vbeta repertoire of anti-hCMV specific memory T-cells in immunocompetent healthy adults
A Rodriguez-Caballero, AC Garcia-Montero, J Almeida, A Balanzategui, S Munoz-Criado, A Orfao |
Cytometry. Part B, Clinical cytometry | 2007 |
Clinical responders to antiviral therapy of chronic HCV infection show elevated antiviral CD4+ and CD8+ T-cell responses
V Pillai, WM Lee, DL Thiele, NJ Karandikar |
Journal of Viral Hepatitis | 2007 |
Cytotoxic T-cell-mediated defense against infections in human liver transplant recipients
K Tanaka, S Uemoto, H Egawa, Y Takada, K Ozawa, S Teramukai, M Kasahara, K Ogawa, M Ono, H Sato, K Takai, M Fukushima, K Inaba |
Liver Transplantation | 2007 |
Initial steroid bolus injection promotes vigorous CD8+ alloreactive responses toward early graft acceptance immediately after liver transplantation in humans
H Egawa, S Uemoto, Y Takada, K Ozawa, S Teramukai, H Haga, M Kasahara, K Ogawa, H Sato, M Ono, K Takai, M Fukushima, K Inaba, K Tanaka |
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society | 2007 |
Optimization and validation of an 8-color intracellular cytokine staining (ICS) assay to quantify antigen-specific T cells induced by vaccination
H Horton, EP Thomas, JA Stucky, I Frank, Z Moodie, Y Huang, YL Chiu, MJ McElrath, SC de Rosa |
Journal of Immunological Methods | 2007 |
Virus-specific T cell responses in macaques acutely infected with SHIV(sf162p3)
B Pahar, X Wang, J Dufour, AA Lackner, RS Veazey |
Virology | 2007 |
Ras/PI3Kinase/cofilin-independent activation of human CD45RA+ and CD45RO+ T cells by superagonistic CD28 stimulation
U Sester, GH Wabnitz, H Kirchgessner, Y Samstag |
European Journal of Immunology | 2007 |
Functional analysis of cytomegalovirus-specific T lymphocytes compared to tetramer assay in patients undergoing hematopoietic stem cell transplantation
Y Morita-Hoshi, Y Heike, M Kawakami, T Sugita, O Miura, SW Kim, SI Mori, T Fukuda, R Tanosaki, K Tobinai, Y Takaue |
Bone Marrow Transplantation | 2007 |
Identification and isolation of murine antigen-reactive T cells according to CD154 expression
D Kirchhoff, M Frentsch, P Leclerk, D Bumann, S Rausch, S Hartmann, A Thiel, A Scheffold |
European Journal of Immunology | 2007 |
Antigen-Specific T-Cell Immunity in Multiple Myeloma Patients is Restored Following High-Dose Therapy: Implications for Timing of Vaccination
IM Svane, K Nikolajsen, HE Johnsen |
Scandinavian Journal of Immunology | 2007 |
HIV/AIDS Vaccines: 2007
HL Robinson |
Clinical Pharmacology & Therapeutics | 2007 |
Frequency and phenotype of EHV-1 specific, IFN-γ synthesising lymphocytes in ponies: The effects of age, pregnancy and infection
R Paillot, JM Daly, R Luce, F Montesso, N Davis-Poynter, D Hannant, JH Kydd |
Developmental & Comparative Immunology | 2007 |
PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status
D Sauce, JR Almeida, M Larsen, L Haro, B Autran, GJ Freeman, V Appay |
AIDS | 2007 |
Perspectives in Medical Virology
KD Mena |
Perspectives in Medical Virology | 2007 |
Identification of an HLA-A24-restricted cytotoxic T lymphocyte epitope from human papillomavirus type-16 E6: the combined effects of bortezomib and interferon-gamma on the presentation of a cryptic epitope
S Morishima, Y Akatsuka, A Nawa, E Kondo, T Kiyono, H Torikai, T Nakanishi, Y Ito, K Tsujimura, K Iwata, K Ito, Y Kodera, Y Morishima, K Kuzushima, T Takahashi |
International Journal of Cancer | 2007 |
Détection par cytométrie en flux des sous-populations lymphocytaires T sécrétrices d'IL-2 et IFN-γ : optimisation de la technique et établissement des valeurs de référence
C Kallel, E Masy, P Duthilleul |
Pathologie Biologie | 2007 |
Adoptive immunotherapy of HCMV infection
M Kapp, SM Tan, H Einsele, GU Grigoleit |
Cytotherapy | 2007 |
Shift of CMV-specific CD4+ T-cells to the highly differentiated CD45RO−CD27− phenotype parallels loss of proliferative capacity and precedes progression to HIV-related CMV end-organ disease
C Bronke, CA Jansen, GH Westerlaken, IM de Cuyper, F Miedema, K Tesselaar, D Baarle |
Clinical Immunology | 2007 |
Human cytomegalovirus (CMV)-specific CD8+ T cell responses are reduced in HIV-infected individuals with a history of CMV disease despite CD4+ T cell recovery
KP Singh, JL Howard, SP Wild, SL Jones, J Hoy, SR Lewin |
Clinical Immunology | 2007 |
Hand Transplantation
M Lanzetta, JM Dubernard, P Petruzzo |
2007 | |
Changes in Paracrine Interleukin-2 Requirement, CCR7 Expression, Frequency, and Cytokine Secretion of Human Immunodeficiency Virus-Specific CD4+ T Cells Are a Consequence of Antigen Load
JC Tilton, MR Luskin, AJ Johnson, M Manion, CW Hallahan, JA Metcalf, M McLaughlin, RT Davey, M Connors |
Journal of virology | 2007 |
Human and Simian Immunodeficiency Virus-Mediated Upregulation of the Apoptotic Factor TRAIL Occurs in Antigen-Presenting Cells from AIDS-Susceptible but Not from AIDS-Resistant Species
N Kim, A Dabrowska, RG Jenner, A Aldovini |
Journal of virology | 2007 |
Induction and Evolution of Cytomegalovirus-Specific CD4 + T Cell Clonotypes in Rhesus Macaques
DA Price, AD Bitmansour, JB Edgar, JM Walker, MK Axthelm, DC Douek, LJ Picker |
Journal of immunology (Baltimore, Md. : 1950) | 2007 |
Multiple-Cytokine-Producing Antiviral CD4 T Cells Are Functionally Superior to Single-Cytokine-Producing Cells
S Kannanganat, C Ibegbu, L Chennareddi, HL Robinson, RR Amara |
Journal of virology | 2007 |
Acquisition of direct antiviral effector functions by CMV-specific CD4 + T lymphocytes with cellular maturation
JP Casazza, MR Betts, DA Price, ML Precopio, LE Ruff, JM Brenchley, BJ Hill, M Roederer, DC Douek, RA Koup |
Journal of Experimental Medicine | 2006 |
Increased hepatitis C virus (HCV)-specific CD4+CD25 + regulatory T lymphocytes and reduced HCV-specific CD4+ T cell response in HCV-infected patients with normal versus abnormal alanine aminotransferase levels
F Bolacchi, A Sinistro, C Ciaprini, F Demin, M Capozzi, FC Carducci, CM Drapeau, G Rocchi, A Bergamini |
Clinical & Experimental Immunology | 2006 |
Diminished frequency of hepatitis C virus specific interferon gamma secreting CD4+ T cells in human immunodeficiency virus/hepatitis C virus coinfected patients
G Harcourt, E Gomperts, S Donfield, P Klenerman |
Gut | 2006 |
VACUTAINER CPT and Ficoll density gradient separation perform equivalently in maintaining the quality and function of PBMC from HIV seropositive blood samples
JJ Ruitenberg, CB Mulder, VC Maino, AL Landay, SA Ghanekar |
BMC Immunology | 2006 |
Monitoring of Human Cytomegalovirus-Specific CD4+and CD8+T-Cell Immunity in Patients Receiving Solid Organ Transplantation
G Gerna, D Lilleri, C Fornara, G Comolli, L Lozza, C Campana, C Pellegrini, F Meloni, T Rampino |
American Journal of Transplantation | 2006 |
Intestinal double-positive CD4+CD8+ T cells are highly activated memory cells with an increased capacity to produce cytokines
B Pahar, AA Lackner, RS Veazey |
European Journal of Immunology | 2006 |
Antigen-specific T cell responses: Determination of their frequencies, homing properties, and effector functions in human whole blood
T Breinig, M Sester, U Sester, A Meyerhans |
Methods | 2006 |
Identification of immunodominant CD4+ T cell epitopes in patients withYersinia-induced reactive arthritis by cytometric cytokine secretion assay
A Thiel, P Wu, M Lanowska, J Dong, A Radbruch, J Sieper |
Arthritis & Rheumatism | 2006 |
Flow cytometric analysis of virus-specific T lymphocytes: Practicability of detection of HCMV-specific T lymphocytes in whole blood in patients after stem cell transplantation
S Buxbaum, FB Kraus, A Hahn, O Beck, B Kabartas, HW Doerr, B Ludwig |
Journal of Immunological Methods | 2006 |
Regulatory T cells generated during cytomegalovirus in vitro stimulation of mononuclear cells from HIV-infected individuals on HAART correlate with decreased lymphocyte proliferation
RD Jesser, S Li, A Weinberg |
Virology | 2006 |
Classification of human liver transplant recipients by their preoperative CD8+ T cell subpopulation and its relation to outcome
K Tanaka, K Ozawa, S Teramukai, Y Takada, H Egawa, S Kaihara, Y Fujimoto, Y Ogura, M Kasahara, M Ono, H Sato, K Takai, M Fukushima, N Minato |
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society | 2006 |
Adoptive T lymphocyte therapy to fight cytomegalovirus infection in immunodeficient hosts
U Grigoleit, M Kapp, H Einsele |
Drug Discovery Today: Therapeutic Strategies | 2006 |
Induction of a virus-specific effector–memory CD4 + T cell response by attenuated SIV infection
MC Gauduin, Y Yu, A Barabasz, A Carville, M Piatak, JD Lifson, RC Desrosiers, RP Johnson |
Journal of Experimental Medicine | 2006 |
Quantitative and Functional Differences between Peripheral Blood Myeloid Dendritic Cells from Patients with Pleural and Parenchymal Lung Tuberculosis
M Mendelson, WA Hanekom, S Ntutela, M Vogt, L Steyn, G Maartens, G Kaplan |
Clinical and vaccine immunology : CVI | 2006 |
Reduced Peripheral and Mucosal Tropheryma whipplei -Specific Th1 Response in Patients with Whipple’s Disease
V Moos, D Kunkel, T Marth, GE Feurle, B LaScola, R Ignatius, M Zeitz, T Schneider |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
Flow Cytometric Detection of Gamma Interferon Can Effectively Discriminate Mycobacterium bovis BCG-Vaccinated Cattle from M. bovis -Infected Cattle
P Sopp, CJ Howard, JC Hope |
Clinical and vaccine immunology : CVI | 2006 |
TIRC7 Inhibits T Cell Proliferation by Modulation of CTLA-4 Expression
GC Bulwin, T Heinemann, V Bugge, M Winter, A Lohan, M Schlawinsky, A Schulze, S Wälter, R Sabat, R Schülein, B Wiesner, RW Veh, J Löhler, RS Blumberg, HD Volk, N Utku |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
HLA-B27-restricted CD8+ T cell response to cartilage-derived self peptides in ankylosing spondylitis
P Atagunduz, H Appel, W Kuon, P Wu, A Thiel, PM Kloetzel, J Sieper |
Arthritis & Rheumatism | 2005 |
T cell subset and cytokine profiles in human visceral leishmaniasis during active and asymptomatic or sub-clinical infection with Leishmania donovani
A Hailu, D Baarle, GJ Knol, N Berhe, F Miedema, PA Kager |
Clinical Immunology | 2005 |
Impact of cryopreservation on tetramer, cytokine flow cytometry, and ELISPOT
HT Maecker, J Moon, S Bhatia, SA Ghanekar, VC Maino, JK Payne, K Kuus-Reichel, JC Chang, A Summers, TM Clay, MA Morse, HK Lyerly, C DeLaRosa, DP Ankerst, ML Disis |
BMC Immunology | 2005 |
Immune dysfunction in endotoxicosis: Role of nitric oxide produced by inducible nitric oxide synthase*
S Miki, N Takeyama, T Tanaka, T Nakatani |
Critical Care Medicine | 2005 |
Development of prophylactic and therapeutic vaccines against hepatitis C virus
G Leroux-Roels |
Expert Review of Vaccines | 2005 |
Direct access to CD4+ T cells specific for defined antigens according to CD154 expression
M Frentsch, O Arbach, D Kirchhoff, B Moewes, M Worm, M Rothe, A Scheffold, A Thiel |
Nature Medicine | 2005 |
Direct Ex Vivo Detection of HLA-DR3–Restricted Cytomegalovirus- and Mycobacterium tuberculosis–Specific CD4+ T Cells
C Bronke, NM Palmer, GH Westerlaken, M Toebes, GM van Schijndel, V Purwaha, KE van Meijgaarden, TN Schumacher, D Baarle, K Tesselaar, A Geluk |
Human Immunology | 2005 |
Lentiviral Vector-Transduced Dendritic Cells Induce Specific T Cell Response in a Nonhuman Primate Model
SK Kung, A Bonifacino, ME Metzger, GE Ringpis, RE Donahue, IS Chen |
Human Gene Therapy | 2005 |
Simultaneous quantification of human cytomegalovirus (HCMV)-specific CD4+ and CD8+T cells by a novel method using monocyte-derived HCMV-infected immature dendritic cells
L Lozza, D Lilleri, E Percivalle, C Fornara, G Comolli, MG Revello, G Gerna |
European Journal of Immunology | 2005 |
Cellular Immune Responses to Cytomegalovirus in Renal Transplant Recipients
R Radha, S Jordan, D Puliyanda, S Bunnapradist, A Petrosyan, N Amet, M Toyoda |
American Journal of Transplantation | 2005 |
T cell vaccines for microbial infections
HL Robinson, RR Amara |
Nature Medicine | 2005 |
Detection of adenovirus-specific T cells in children with adenovirus infection after allogeneic stem cell transplantation
T Feuchtinger, J Lücke, K Hamprecht, C Richard, R Handgretinger, M Schumm, J Greil, T Bock, D Niethammer, P Lang |
British Journal of Haematology | 2005 |
Measuring Ag-specific immune responses: understanding immunopathogenesis and improving diagnostics in infectious disease, autoimmunity and cancer
F Kern, G LiPira, JW Gratama, F Manca, M Roederer |
Trends in Immunology | 2005 |
Clinical, Microbiological, and Immunological Characteristics in HIV-Infected Subjects at Risk for DisseminatedMycobacterium aviumComplex Disease: An AACTG Study
RR MacGregor, R Hafner, JW Wu, RL Murphy, DC Perlman, LE Bermudez, CB Inderlied, LJ Picker, RS Wallis, JW Andersen, LF Mahon, SL Koletar, DM Peterson |
AIDS Research and Human Retroviruses | 2005 |
ACSD labelling and magnetic cell separation: a rapid method of separating antibody secreting cells from non-secreting cells
S Carroll, M Al-Rubeai |
Journal of Immunological Methods | 2005 |
Measuring Immunity
MT Stang, JH Yim |
Measuring Immunity | 2005 |
The Laboratory Primate
C Szabo |
The Laboratory Primate | 2005 |
Broadly targeted human cytomegalovirus-specific CD4 + and CD8 + T cells dominate the memory compartments of exposed subjects
AW Sylwester, BL Mitchell, JB Edgar, C Taormina, C Pelte, F Ruchti, PR Sleath, KH Grabstein, NA Hosken, F Kern, JA Nelson, LJ Picker |
Journal of Experimental Medicine | 2005 |
The Grand Challenge for the Future
SH Kaufmann, PH Lambert |
2005 | |
In vitro Induction of Myeloid Leukemia–Specific CD4 and CD8 T Cells by CD40 Ligand – Activated B Cells Gene Modified to Express Primary Granule Proteins
H Fujiwara, JJ Melenhorst, FE Ouriaghli, S Kajigaya, M Grube, G Sconocchia, K Rezvani, DA Price, NF Hensel, DC Douek, AJ Barrett |
Clinical cancer research | 2005 |
Optimization of CD4 + T Lymphocyte Response to Human Cytomegalovirus Nuclear IE1 Protein through Modifications of Both Size and Cellular Localization
S Delmas, L Martin, M Baron, JA Nelson, DN Streblow, JL Davignon |
Journal of immunology (Baltimore, Md. : 1950) | 2005 |
Immunogenic Properties of a Chimeric Plant Virus Expressing a Hepatitis C Virus (HCV)-Derived Epitope: New Prospects for an HCV Vaccine
G Piazzolla, M Nuzzaci, C Tortorella, E Panella, A Natilla, D Boscia, AD Stradis, P Piazzolla, S Antonaci |
Journal of Clinical Immunology | 2005 |
Virology Research
Peter B, Marta M, Nicholas L, Michael B. M, Christopher J. M |
The Laboratory Primate | 2005 |
Vaccination in humans generates broad T cell cytokine responses
SC de Rosa, FX Lu, J Yu, SP Perfetto, J Falloon, S Moser, TG Evans, R Koup, CJ Miller, M Roederer |
Journal of immunology (Baltimore, Md. : 1950) | 2004 |
Persistent and selective deficiency of CD4+ T cell immunity to cytomegalovirus in immunocompetent young children
W Tu, S Chen, M Sharp, C Dekker, AM Manganello, EC Tongson, HT Maecker, TH Holmes, Z Wang, G Kemble, S Adler, A Arvin, DB Lewis |
Journal of immunology (Baltimore, Md. : 1950) | 2004 |
Age-associated change in the frequency of memory CD4+ T cells impairs long term CD4+ T cell responses to influenza vaccine
I Kang, MS Hong, H Nolasco, SH Park, JM Dan, JY Choi, J Craft |
Journal of immunology (Baltimore, Md. : 1950) | 2004 |
Emergence of a CD4+CD28- granzyme B+, cytomegalovirus-specific T cell subset after recovery of primary cytomegalovirus infection
EM van Leeuwen, EB Remmerswaal, MT Vossen, AT Rowshani, PM Dillen, RA van Lier, IJ Berge |
Journal of immunology (Baltimore, Md. : 1950) | 2004 |
Functional assessment and specific depletion of alloreactive human T cells using flow cytometry
SL Martins, LS st John, RE Champlin, ED Wieder, J McMannis, JJ Molldrem, KV Komanduri |
Blood | 2004 |
High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay
MP Crawford, SX Yan, SB Ortega, RS Mehta, RE Hewitt, DA Price, P Stastny, DC Douek, RA Koup, MK Racke, NJ Karandikar |
Blood | 2004 |
Defective control of latent Epstein-Barr virus infection in systemic lupus erythematosus
I Kang, T Quan, H Nolasco, SH Park, MS Hong, J Crouch, EG Pamer, JG Howe, J Craft |
Journal of immunology (Baltimore, Md. : 1950) | 2004 |
Analysis of the CD8+ T cell response to the G1 domain of aggrecan in ankylosing spondylitis
J Zou, H Appel, M Rudwaleit, A Thiel, J Sieper |
Annals of the rheumatic diseases | 2004 |
Assessment of human cytomegalovirus specific T cell immunity in human immunodeficiency virus infected patients in different disease stages following HAART and in long-term non-progressors
A Tamarit, J Alberola, JV Mira, C Tornero, MJ Galindo, D Navarro |
Journal of Medical Virology | 2004 |
CMV antigen-specific CD4+ and CD8+ T cell IFNgamma expression and proliferation responses in healthy CMV-seropositive individuals
E Sinclair, D Black, CL Epling, A Carvidi, SZ Josefowicz, BM Bredt, MA Jacobson |
Viral Immunology | 2004 |
Cofilin peptide homologs interfere with immunological synapse formation and T cell activation
SM Eibert, KH Lee, R Pipkorn, U Sester, GH Wabnitz, T Giese, SC Meuer, Y Samstag |
Proceedings of the National Academy of Sciences | 2004 |
Investigations on four host response factors whose expression is enhanced in X4 SHIV encephalitis
S Buch, Y Sui, N Dhillon, R Potula, C Zien, D Pinson, S Li, S Dhillon, B Nicolay, A Sidelnik, C Li, T Villinger, K Bisarriya, O Narayan |
Journal of Neuroimmunology | 2004 |
Impact of vector-priming on the immunogenicity of a live recombinant Salmonella enterica serovar typhi Ty21a vaccine expressing urease A and B from Helicobacter pylori in human volunteers
WG Metzger, E Mansouri, M Kronawitter, S Diescher, M Soerensen, R Hurwitz, D Bumann, T Aebischer, BU Specht, TF Meyer |
Vaccine | 2004 |
Assessment of cellular immunity to human cytomegalovirus in recipients of allogeneic stem cell transplants
SF Lacey, DJ Diamond, JA Zaia |
Biology of Blood and Marrow Transplantation | 2004 |
Detection of antigen-specific lymphocytes/Detektion von Antigen-spezifischen Lymphozyten
A Scheffold, A Thiel |
LaboratoriumsMedizin | 2004 |
CD28 costimulation enhances the sensitivity of the ELISPOT assay for detection of antigen-specific memory effector CD4 and CD8 cell populations in human diseases
PA Ott, BR Berner, BA Herzog, R Guerkov, NL Yonkers, I Durinovic-Bello, M Tary-Lehmann, PV Lehmann, DD Anthony |
Journal of Immunological Methods | 2004 |
Cytokine flow cytometry: a multiparametric approach for assessing cellular immune responses to viral antigens
VC Maino, HT Maecker |
Clinical Immunology | 2004 |
Flow cytometric enumeration of antigen-specific T lymphocytes
JW Gratama, F Kern |
Cytometry | 2004 |
Analysis of Ehrlichia ruminantium-specific T1/T2 responses during vaccination with a protective killed vaccine and challenge of goats
I Esteves, N Vachiery, D Martinez, P Totte |
Parasite Immunology | 2004 |
CMV Antigen-Specific CD4+and CD8+T Cell IFNγ Expression and Proliferation Responses in Healthy CMV-Seropositive Individuals
E Sinclair, D Black, CL Epling, A Carvidi, SZ JosefowicZ, BM Bredt, MA Jacobson |
Viral Immunology | 2004 |
Vaccine Development to Prevent Cytomegalovirus Disease: Report from the National Vaccine Advisory Committee
JF Modlin, AM Arvin, P Fast, M Myers, S Plotkin, R Rabinovich |
Clinical Infectious Diseases | 2004 |
Editorial: Analysis of cell function in flow cytometric immunophenotyping/Editorial: Funktionelle Charakterisierung von Zellen bei der durchflusszytometrischen Immunphänotypisierung
G Rothe |
LaboratoriumsMedizin | 2004 |
HIV Type 1 Antigen-Responsive CD4+T-Lymphocytes in Exposed Yet HIV Type 1 Seronegative Ugandans
A Kebba, P Kaleebu, J Serwanga, S Rowland, D Yirrell, R Downing, J Gilmour, N Imami, F Gotch, J Whitworth |
AIDS Research and Human Retroviruses | 2004 |
T Cell Immunity to Measles Viral Proteins in Infants and Adults after Measles Immunization
HA Gans, LL Yasukawa, A Alderson, M Rinki, R Dehovitz, Y Maldonado, AM Arvin |
Viral Immunology | 2004 |
Analyzing t-cell responses to cytomegalovirus by cytokine flow cytometry
HT Maecker, VC Maino |
Human Immunology | 2004 |
Optimization of intracellular cytokine staining for the quantitation of antigen-specific CD4+ T cell responses in rhesus macaques
MC Gauduin, A Kaur, S Ahmad, T Yilma, JD Lifson, RP Johnson |
Journal of Immunological Methods | 2004 |
Optimum culture conditions for specific and nonspecific activation of whole blood and PBMC for intracellular cytokine assessment by flow cytometry
K Godoy-Ramirez, K Franck, S Mahdavifar, L Andersson, H Gaines |
Journal of Immunological Methods | 2004 |
Quantitation of dengue virus specific CD4+ T cells by intracellular cytokine staining
MM Mangada, FA Ennis, AL Rothman |
Journal of Immunological Methods | 2004 |
Novel application of a whole blood intracellular cytokine detection assay to quantitate specific T-cell frequency in field studies
WA Hanekom, J Hughes, M Mavinkurve, M Mendillo, M Watkins, H Gamieldien, SJ Gelderbloem, M Sidibana, N Mansoor, V Davids, RA Murray, A Hawkridge, PA Haslett, S Ress, GD Hussey, G Kaplan |
Journal of Immunological Methods | 2004 |
Properties of CD4(+) T cells in human cytomegalovirus infection
LE Gamadia, RJ Rentenaar, RA van Lier, IJ Berge |
Human Immunology | 2004 |
Consolidation with alemtuzumab in patients with chronic lymphocytic leukemia (CLL) in first remission – experience on safety and efficacy within a randomized multicenter phase III trial of the German CLL Study Group (GCLLSG)
CM Wendtner, M Ritgen, CD Schweighofer, G Fingerle-Rowson, H Campe, G Jäger, B Eichhorst, R Busch, H Diem, A Engert, S Stilgenbauer, H Döhner, M Kneba, B Emmerich, M Hallek |
Leukemia | 2004 |
Patterns of intracellular cytokines in CD4 and CD8 T cells from patients with mycobacterial infections
PR Antas, JS Sales, KC Pereira, EB Oliveira, KS Cunha, EN Sarno, EP Sampaio |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] | 2004 |
Oral valganciclovir in children: single dose pharmacokinetics in a six-year-old girl:
M Burri, H Wiltshire, C Kahlert, G Wouters, C Rudin |
The Pediatric Infectious Disease Journal | 2004 |
Cancer Immunotherapy at the Crossroads
JH Finke, RM Bukowski |
2004 | |
Handbook of Cancer Vaccines
MA Morse, TM Clay, HK Lyerly |
2004 | |
Reconstitution of HLA-A*2402-Restricted Cytomegalovirus-Specific T-Cells following Stem Cell Transplantation
H Gondo, D Himeji, K Kamezaki, A Numata, T Tanimoto, K Takase, K Aoki, H Henzan, K Nagafuji, T Miyamoto, F Ishikawa, K Shimoda, S Inaba, H Tsukamoto, T Horiuchi, H Nakashima, T Otsuka, K Kato, M Kuroiwa, M Higuchi, T Shibuya, T Kamimura, K Kuzushima, T Tsurumi, Y Kanda, M Harada |
International Journal of Hematology | 2004 |
Rapid generation of combined CMV-specific CD4+ and CD8+ T-cell lines for adoptive transfer into recipients of allogeneic stem cell transplants
G Rauser, H Einsele, C Sinzger, D Wernet, G Kuntz, M Assenmacher, JD Campbell, MS Topp |
Blood | 2004 |
Age-Related Impaired Type 1 T Cell Responses to Influenza: Reduced Activation Ex Vivo, Decreased Expansion in CTL Culture In Vitro, and Blunted Response to Influenza Vaccination In Vivo in the Elderly
Y Deng, Y Jing, AE Campbell, S Gravenstein |
Journal of immunology (Baltimore, Md. : 1950) | 2004 |
Identification and in vitro expansion of CD4+ and CD8+ T cells specific for human neutrophil elastase
H Fujiwara, FE Ouriaghli, M Grube, DA Price, K Rezvani, E Gostick, G Sconocchia, J Melenhorst, N Hensel, DC Douek, AJ Barrett |
Blood | 2004 |
Beyond Help: Direct Effector Functions of Human Immunodeficiency Virus Type 1-Specific CD4 + T Cells
PJ Norris, HF Moffett, OO Yang, DE Kaufmann, MJ Clark, MM Addo, ES Rosenberg |
Journal of virology | 2004 |
TIRC7 Deficiency Causes In Vitro and In Vivo Augmentation of T and B Cell Activation and Cytokine Response
N Utku, A Boerner, A Tomschegg, F Bennai-Sanfourche, GC Bulwin, T Heinemann, J Loehler, RS Blumberg, HD Volk |
Journal of immunology (Baltimore, Md. : 1950) | 2004 |
Automation of Cytokine Flow Cytometry Assays
JF Dunne, HT Maecker |
JALA (Charlottesville, Va.) | 2004 |
II, 11. Human adaptive immunity to rotaviruses: A model of intestinal mucosal adaptive immunity.
Gonzalez AM, Jaimes MC, Rojas OL, Angel J, Greenberg HB, A Franco M |
Perspectives in Medical Virology | 2004 |
Toll-like receptor ligands modulate dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses
K Loré, MR Betts, JM Brenchley, J Kuruppu, S Khojasteh, S Perfetto, M Roederer, RA Seder, RA Koup |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
Immunity to human immunodeficiency virus (HIV) in children with chronic HIV infection receiving highly active antiretroviral therapy
A Weinberg, GB Pott |
Clinical and diagnostic laboratory immunology | 2003 |
Performance of plate-based cytokine flow cytometry with automated data analysis
MA Suni, HS Dunn, PL Orr, R Laat, E Sinclair, SA Ghanekar, BM Bredt, JF Dunne, VC Maino, HT Maecker |
BMC Immunology | 2003 |
Cellular responses to cytomegalovirus in immunosuppressed patients: circulating CD8+ T cells recognizing CMVpp65 are present but display functional impairment
M Engstrand, AK Lidehall, TH Totterman, B Herrman, BM Eriksson, O Korsgren |
Clinical & Experimental Immunology | 2003 |
Multiple relapses of human cytomegalovirus retinitis during HAART in an AIDS patient with reconstitution of CD4+ T cell count in the absence of HCMV-specific CD4+ T cell response
D Lilleri, G Piccinini, F Baldanti, E Seminari, D Galloni, G Gerna |
Journal of Clinical Virology | 2003 |
Extensive MHC class I-restricted CD8 T lymphocyte responses against various yeast genera in humans
T Heintel, F Breinig, MJ Schmitt, A Meyerhans |
FEMS Immunology & Medical Microbiology | 2003 |
Diagnostic potential of tetramer-based monitoring of cytomegalovirus-specific cd8+ t lymphocytes in allogeneic stem cell transplantation
JW Gratama, JJ Cornelissen |
Clinical Immunology | 2003 |
Detection of GAD-Reactive CD4+ Cells in So-Called “Type 1B” Diabetes
A Shimada, K Kodama, J Morimoto, Y Oikawa, J Irie, Y Nakagawa, K Matsubara, T Maruyama, T Saruta |
Annals of the New York Academy of Sciences | 2003 |
Detection of antigen-specific T cell interferon γ expression by ELISPOT and cytokine flow cytometry assays in rhesus macaques
B Pahar, J Li, T Rourke, CJ Miller, MB McChesney |
Journal of Immunological Methods | 2003 |
Human cytomegalovirus infection during pregnancy and detection of specific T cells by intracellular cytokine staining
T Fujikawa, K Numazaki, H Asanuma, H Tsutsumi |
International Journal of Infectious Diseases | 2003 |
Gradual development of the interferon-γ response of swine to porcine reproductive and respiratory syndrome virus infection or vaccination
WA Meier, J Galeota, FA Osorio, RJ Husmann, WM Schnitzlein, FA Zuckermann |
Virology | 2003 |
Beyond six colors: A new era in flow cytometry
SC de Rosa, JM Brenchley, M Roederer |
Nature Medicine | 2003 |
Evidence for Gag p24-specific CD4 T cells with reduced susceptibility to R5 HIV-1 infection in a UK cohort of HIV-exposed-seronegative subjects:
J Eyeson, D King, MJ Boaz, E Sefia, S Tomkins, A Waters, PJ Easterbrook, A Vyakarnam |
AIDS | 2003 |
Flow cytometric analysis of cytomegalovirus-specific cell-mediated immunity in the congenital infection
N Hayashi, H Kimura, T Morishima, N Tanaka, T Tsurumi, K Kuzushima |
Journal of Medical Virology | 2003 |
Frequency of human cytomegalovirus-specific T cells during pregnancy determined by intracellular cytokine staining
T Fujikawa, K Numazaki, H Asanuma, R Kudo, H Tsutsumi |
Journal of Medical Virology | 2003 |
HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages
E Izmailova, FM Bertley, Q Huang, N Makori, CJ Miller, RA Young, A Aldovini |
Nature Medicine | 2003 |
Molekularmedizinische Grundlagen von rheumatischen Erkrankungen
D Ganten, K Ruckpaul, S Gay, JR Kalden |
2003 | |
Heat Shock Proteins and Inflammation
W van Eden |
2003 | |
Cutting Edge: L-Selectin (CD62L) Expression Distinguishes Small Resting Memory CD4 + T Cells That Preferentially Respond to Recall Antigen
RL Hengel, V Thaker, MV Pavlick, JA Metcalf, G Dennis, J Yang, RA Lempicki, I Sereti, HC Lane |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
Local Cooperation Dominates Over Competition Between CD4 + T Cells of Different Antigen/MHC Specificity
RJ Creusot, LL Thomsen, JP Tite, BM Chain |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
Identification of Immunodominant Epitopes Derived from the Respiratory Syncytial Virus Fusion Protein That Are Recognized by Human CD4 T Cells
GM van Bleek, MC Poelen, R van der Most, HF Brugghe, HA Timmermans, CJ Boog, P Hoogerhout, HG Otten, CA van Els |
Journal of virology | 2003 |
Glatiramer acetate (Copaxone) therapy Induces CD8+ T cell responses in patients with Multiple Sclerosis
Nitin J. Karandikar, Michael P. Crawford, Robert B. Ratts, Jason M. Brenchley, David R. Ambrozak, Amy E. Lovett-Racke, Elliot M. Frohman, Peter Stastny, Daniel C. Douek, Richard A. Koup, Michael K. Racke |
Journal of Clinical Investigation | 2002 |
Target Organ Localization of Memory CD4+ T Cells in Patients with Chronic Beryllium Disease
Andrew P. Fontenot, Scott J. Canavera, Laia Gharavi, Lee S. Newman, Brian L. Kotzin |
Journal of Clinical Investigation | 2002 |
T Cell Receptor beta Chain Gene Usage in Endemic Pemphigus Foliaceus (Fogo Selvagem)
AK Moesta, MS Lin, LA Diaz, AA Sinha |
Journal of Investigative Dermatology | 2002 |
Primary immune responses to human CMV: a critical role for IFN-gamma-producing CD4+ T cells in protection against CMV disease
LE Gamadia, EB Remmerswaal, JF Weel, F Bemelman, RA van Lier, IJ Berge |
Blood | 2002 |
Persistent numbers of tetramer+ CD8(+) T cells, but loss of interferon-gamma+ HIV-specific T cells during progression to AIDS
S Kostense, K Vandenberghe, J Joling, DV Baarle, N Nanlohy, E Manting, F Miedema |
Blood | 2002 |
HIV antigens can induce TGF-beta(1)-producing immunoregulatory CD8+ T cells
ML Garba, CD Pilcher, AL Bingham, J Eron, JA Frelinger |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
Cytomegalovirus reactivation following allogeneic stem cell transplantation is associated with the presence of dysfunctional antigen-specific CD8+ T cells
E Ozdemir, LS st John, G Gillespie, S Rowland-Jones, RE Champlin, JJ Molldrem, KV Komanduri |
Blood | 2002 |
Epitope-specific Evolution of Human CD8 + T Cell Responses from Primary to Persistent Phases of Epstein-Barr Virus Infection
AD Hislop, NE Annels, NH Gudgeon, AM Leese, AB Rickinson |
Journal of Experimental Medicine | 2002 |
Frequencies of Virus-Specific CD4 + and CD8 + T Lymphocytes Secreting Gamma Interferon after Acute Natural Rotavirus Infection in Children and Adults
MC Jaimes, OL Rojas, AM González, I Cajiao, A Charpilienne, P Pothier, E Kohli, HB Greenberg, MA Franco, J Angel |
Journal of virology | 2002 |
Cellular methods used to evaluate the immune response in transplantation: Reinsmoen : Evaluation of immune response in transplantation
NL Reinsmoen |
Tissue Antigens | 2002 |
HIV preferentially infects HIV-specific CD4+ T cells
DC Douek, JM Brenchley, MR Betts, DR Ambrozak, BJ Hill, Y Okamoto, JP Casazza, J Kuruppu, K Kunstman, S Wolinsky, Z Grossman, M Dybul, A Oxenius, DA Price, M Connors, RA Koup |
Nature | 2002 |
CD8+T-Cell Response Against Hepatitis C Virus
XS He, HB Greenberg |
Viral Immunology | 2002 |
S antigen specific effector T cell activation detected by cytokine flow cytometry
JP Morgan, RA Robins, HS Dua, PJ Tighe |
The British journal of ophthalmology | 2002 |
Immunologic Monitoring of Cancer Vaccine Therapy: Results of a Workshop Sponsored by the Society for Biological Therapy
U Keilholz, J Weber, JH Finke, DI Gabrilovich, WM Kast, ML Disis, JM Kirkwood, C Scheibenbogen, J Schlom, VC Maino, HK Lyerly, PP Lee, W Storkus, F Marincola, A Worobec, MB Atkins |
Journal of Immunotherapy | 2002 |
Increasing CD4+T Cells Specific for Tuberculosis Correlate with Improved Clinical Immunity after Highly Active Antiretroviral Therapy
RL Hengel, MC Allende, RL Dewar, JA Metcalf, JA Mican, HC Lane |
AIDS Research and Human Retroviruses | 2002 |
Peripheral blood CD4+ and CD8+ T cell type 1 and type 2 cytokine production in atopic asthmatic and normal subjects
SH Cho, LA Stanciu, T Begishivili, PJ Bates, ST Holgate, SL Johnston |
Clinical & Experimental Allergy | 2002 |
Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine
RR Amara, F Villinger, JD Altman, SL Lydy, SP O’Neil, SI Staprans, DC Montefiori, Y Xu, JG Herndon, LS Wyatt, MA Candido, NL Kozyr, PL Earl, JM Smith, HL Ma, BD Grimm, ML Hulsey, HM McClure, JM McNicholl, B Moss, HL Robinson |
Vaccine | 2002 |
A randomized, placebo-controlled trial of subcutaneous administration of GM-CSF as a vaccine adjuvant: effect on cellular and humoral immune responses
J Somani, S Lonial, H Rosenthal, S Resnick, I Kakhniashvili, EK Waller |
Vaccine | 2002 |
Human T cells that have been conditioned by the proteolytic activity of the major dust mite allergen Der p 1 trigger enhanced immunoglobulin E synthesis by B cells
AM Ghaemmaghami, F Shakib |
Clinical & Experimental Allergy | 2002 |
The Dual Role of CD4 T Helper Cells in the Infection Dynamics of HIV and Their Importance for Vaccination
HK Altes, D Wodarz, V Jansen |
Journal of Theoretical Biology | 2002 |
Efficacy of a B virus gD DNA vaccine for induction of humoral and cellular immune responses in Japanese macaques
M Hirano, S Nakamura, F Mitsunaga, M Okada, K Shimizu, M Ueda, A Bennett, R Eberle |
Vaccine | 2002 |
CD4+T cell levels are decreased during active CMV infection in kidney transplant recipients
S Essa, AS Pacsa, R Raghupathy, R Al-Attiyah, A El-Shazly, T Said |
FEMS Immunology & Medical Microbiology | 2002 |
Multiparameter cytokine-specific affinity matrix assay for the determination of frequencies and phenotype of antigen-reactive T cells
G Mathioudakis, D Coder, A Fefer |
Journal of Immunological Methods | 2002 |
Application of a 5-bromo-2′-deoxyuridine ELISA for measuring the lymphoproliferative response to human cytomegalovirus in HIV-1-infected patients
A Tamarit, J Alberola, MJ Galindo, D Navarro |
Journal of Virological Methods | 2002 |
Methods in Cell Biology
JW Smith |
Methods in cell biology | 2002 |
Gene Therapy in Lung Disease
K Amin |
Gene Therapy in Lung Disease | 2002 |
Functional discrepancies in HIV-specific CD8+ T-lymphocyte populations are related to plasma virus load
A Oxenius, AK Sewell, SJ Dawson, HF Günthard, M Fischer, GM Gillespie, SL Rowland-Jones, C Fagard, B Hirschel, RE Phillips, DA Price, |
Journal of Clinical Immunology | 2002 |
Cytomegalovirus infections in kidney transplant patients
N Babel, F Kern, HD Volk, P Reinke |
Transplantation Reviews | 2002 |
Clinical trials with CMV-specific T cells
KS Peggs, S Mackinnon |
Cytotherapy | 2002 |
Flow cytometric quantitation and characterization of the T-lymphocyte memory response to CMV in healthy donors
N Hensel, JJ Melenhorst, K Bradstock, AP Schwarer, R Eniafe, R Nakamura, AJ Barrett |
Cytotherapy | 2002 |
Thymic function and allogeneic T-cell responses in stem-cell transplantation
KV Komanduri |
Cytotherapy | 2002 |
Impact of high-dose chemotherapy on antigen-specific T cell immunity in breast cancer patients. Application of new flow cytometric method
IM Svane, K Nikolajsen, SW Hansen, C Kamby, DL Nielsen, HE Johnsen |
Bone Marrow Transplantation | 2002 |
Frequencies of HCV-specific effector CD4+ T cells by flow cytometry: Correlation with clinical disease stages
H Rosen |
Hepatology | 2002 |
Dendritic cells cross-presenting viral antigens derived from autologous cells as a sensitive tool for visualization of human cytomegalovirus-reactive CD8+ T cells1:
MJ Raftery, M Schwab, S Diesner, G Egerer, G Schonrich |
Transplantation | 2002 |
Human Cell Culture
MR Koller, BO Palsson, JR Masters |
2002 | |
Beryllium Skin Patch Testing to Analyze T Cell Stimulation and Granulomatous Inflammation in the Lung
AP Fontenot, LA Maier, SJ Canavera, TB Hendry-Hofer, M Boguniewicz, EA Barker, LS Newman, BL Kotzin |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
Development and Homeostasis of T Cell Memory in Rhesus Macaque
CJ Pitcher, SI Hagen, JM Walker, R Lum, BL Mitchell, VC Maino, MK Axthelm, LJ Picker |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
Decreased Frequency of Cytomegalovirus (CMV)-Specific CD4 + T Lymphocytes in Simian Immunodeficiency Virus-Infected Rhesus Macaques: Inverse Relationship with CMV Viremia
A Kaur, CL Hale, B Noren, N Kassis, MA Simon, RP Johnson |
Journal of virology | 2002 |
Sensitive detection of human cytomegalovirus peptide–specific cytotoxic T-lymphocyte responses by interferon-γ–enzyme-linked immunospot assay and flow cytometry in healthy individuals and in patients after allogeneic stem cell transplantation
H Hebart, S Daginik, S Stevanovic, U Grigoleit, A Dobler, M Baur, G Rauser, C Sinzger, G Jahn, J Loeffler, L Kanz, HG Rammensee, H Einsele |
Blood | 2002 |
Infection of APC by Human Cytomegalovirus Controlled Through Recognition of Endogenous Nuclear Immediate Early Protein 1 by Specific CD4 + T Lymphocytes
EL Roy, M Baron, W Faigle, D Clément, DM Lewinsohn, DN Streblow, JA Nelson, S Amigorena, JL Davignon |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
Quantitation, selection, and functional characterization of Epstein-Barr virus–specific and alloreactive T cells detected by intracellular interferon-γ production and growth of cytotoxic precursors
G Koehne, KM Smith, TL Ferguson, RY Williams, G Heller, EG Pamer, B Dupont, RJ O'Reilly |
Blood | 2002 |
Direct Ex Vivo Analysis of Human CD4 + Memory T Cell Activation Requirements at the Single Clonotype Level
AD Bitmansour, DC Douek, VC Maino, LJ Picker |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
Detection of Intracellular Cytokines by Flow Cytometry
B Foster, C Prussin |
Current protocols in immunology / edited by John E. Coligan ... [et al.] | 2002 |
Differentiation of cytomegalovirus-specific CD8(+) T cells in healthy and immunosuppressed virus carriers
LE Gamadia, RJ Rentenaar, PA Baars, EB Remmerswaal, S Surachno, JF Weel, M Toebes, TN Schumacher, IJ Berge, RA van Lier |
Blood | 2001 |
Identification of HLA-B27-restricted peptides from the Chlamydia trachomatis proteome with possible relevance to HLA-B27-associated diseases
W Kuon, HG Holzhütter, H Appel, M Grolms, S Kollnberger, A Traeder, P Henklein, E Weiss, A Thiel, R Lauster, P Bowness, A Radbruch, PM Kloetzel, J Sieper |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
High-level HIV-1 viremia suppresses viral antigen-specific CD4(+) T cell proliferation
AC McNeil, WL Shupert, CA Iyasere, CW Hallahan, JA Mican, RT Davey, M Connors |
Proceedings of the National Academy of Sciences | 2001 |
Multiple Effector Functions Mediated by Human Immunodeficiency Virus-Specific CD4 + T-Cell Clones
PJ Norris, M Sumaroka, C Brander, HF Moffett, SL Boswell, T Nguyen, Y Sykulev, BD Walker, ES Rosenberg |
Journal of virology | 2001 |
Current Protocols in Immunology
EH Leiter |
Current Protocols in Immunology | 2001 |
New insights into evaluating effective T-cell responses to HIV
TM Allen, DI Watkins |
AIDS | 2001 |
High frequency of circulating HBcAg-specific CD8 T cells in hepatitis B infection: a flow cytometric analysis
S Matsumura, K Yamamoto, N Shimada, N Okano, R Okamoto, T Suzuki, T Hakoda, M Mizuno, T Higashi, T Tsuji |
Clinical & Experimental Immunology | 2001 |
Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize the beta -chemokine macrophage inflammatory protein-1beta
R Kamin-Lewis, SF Abdelwahab, C Trang, A Baker, AL DeVico, RC Gallo, GK Lewis |
Proceedings of the National Academy of Sciences | 2001 |
Lack of evidence for the Th2 predominance in patients with chronic hepatitis C
A Bergamini, F Bolacchi, G Cerasari, C Carvelli, E Faggioli, M Cepparulo, F Demin, I Uccella, B Bongiovanni, P Niutta, M Capozzi, M Lupi, E Piscitelli, G Rocchi, M Angelico |
Clinical & Experimental Immunology | 2001 |
Interferon-gamma administration after abdominal surgery rescues antigen-specific helper T cell immune reactivity
RJ Rentenaar, J Metz, M Bunders, PM Dillen, DJ Gouma, JA Romijn, HP Sauerwein, IJ Berge, RA van Lier |
Clinical & Experimental Immunology | 2001 |
In vitro hydroxyurea decreases Th1 cell-mediated immunity
A Weinberg |
Clinical and diagnostic laboratory immunology | 2001 |
CMVR diagnoses and progression of CD4 cell counts and HIV viral load measurements in HIV patients on HAART
HJ Zambarakji, RB Newson, SM Mitchell |
The British journal of ophthalmology | 2001 |
Expression of perforin on HIV-1-specific CD8+ lymphocytes after immunization with a gp120-depleted, whole-killed HIV-1 immunogen
RB Moss, WK Giermakowska, MR Wallace, FC Jensen, RZ Maigetter, DJ Carlo |
Clinical & Experimental Immunology | 2001 |
Detection and quantification of HIV-1 specific CD4 helper and CD8 cytotoxic cells: their role in HIV-1-infected individuals and vaccine recipients
N Imami, G Hardy, A Pires, C Burton, A Sullivan, F Gotch |
HIV Medicine | 2001 |
Cell function-based flow cytometry
JJ Bleesing, TA Fleisher |
Seminars in Hematology | 2001 |
Quantitative Analysis of Adenovirus-Specific CD4+T-Cell Responses from Healthy Adults
M Olive, LC Eisenlohr, P Flomenberg |
Viral Immunology | 2001 |
Analysis of the antigen specific T cell repertoires in HIV infection
GL Pira, L Bottone, D Fenoglio, P Terranova, E Pontali, F Ivaldi, FD Galdo, L Mortara, A Loregian, G Palù, A Kunkl, R Accolla, RD Palma, F Manca |
Immunology Letters | 2001 |
Quantitative analysis of specific Th1/Th2 helper cell responses and IgG subtype antibodies in interferon-?-treated patients with chronic hepatitis C
G Hempel, PR Galle, HF L�hr |
Journal of Medical Virology | 2001 |
Insights into the Specificity and Function of (Allo)antigen-reactive T Cells
HD Volk, F Kern |
American Journal of Transplantation | 2001 |
Human T cell subset commitment determined by the intrinsic property of antigen: the proteolytic activity of the major mite allergen Der p 1 conditions T cells to produce more IL-4 and less IFN-γ
AM Ghaemmaghami, A Robins, L Gough, HF Sewell, F Shakib |
European Journal of Immunology | 2001 |
Sustained Cytomegalovirus-Specific CD4+T Cell Response Associated with Prevention of Recurrence of Cytomegalovirus Retinitis without Secondary Prophylaxis after Highly Active Antiretroviral Therapy in Patients with AIDS
M Tanaka, C Yasuoka, I Genka, N Tachikawa, Y Kikuchi, K Teruya, A Yasuoka, Y Hirabayashi, S Kimura, S Oka |
AIDS Research and Human Retroviruses | 2001 |
Direct Functional Analysis of Epitope-Specific CD8+T Cells in Peripheral Blood
XS He, B Rehermann, J Boisvert, J Mumm, HT Maecker, M Roederer, TL Wright, VC Maino, MM Davis, HB Greenberg |
Viral Immunology | 2001 |
Routine detection of Epstein–Barr virus specific T-cells in the peripheral blood by flow cytometry
BE Crucian, RP Stowe, DL Pierson, CF Sams |
Journal of Immunological Methods | 2001 |
Ex vivo analysis of tumor antigen specific CD8+ T cell responses using MHC/peptide tetramers in cancer patients
MJ Pittet, DE Speiser, D Valmori, D Rimoldi, D Liénard, F Lejeune, JC Cerottini, P Romero |
International Immunopharmacology | 2001 |
Direct Measurement of CD4+ and CD8+ T-Cell Responses to CMV in HIV-1-Infected Subjects
KV Komanduri, SM Donahoe, WJ Moretto, DK Schmidt, G Gillespie, GS Ogg, M Roederer, DF Nixon, JM McCune |
Virology | 2001 |
Potential clinical utility of monitoring cytomegalovirus-specific T lymphocytes in allogeneic stem cell transplantation
JW Gratama, JJ Cornelissen |
Clinical and Applied Immunology Reviews | 2001 |
Longitudinal analysis of T-cell receptor gene use by CD8(+) T cells in early human immunodeficiency virus infection in patients receiving highly active antiretroviral therapy
AM Schito, E Vittinghoff, FM Hecht, MK Elkins, JO Kahn, JA Levy, JR Oksenberg |
Blood | 2001 |
Direct detection of cellular immune responses to cancer vaccines
PJ Mosca, AC Hobeika, TM Clay, MA Morse, HK Lyerly |
Surgery | 2001 |
Detection of allospecific T cells by intracellular cytokine staining and flowcytometry
RJ Rentenaar, JL Vosters, RA Lier, IJ Berge |
Transplantation Proceedings | 2001 |
Use of overlapping peptide mixtures as antigens for cytokine flow cytometry
H T Maecker, H S Dunn, M A Suni, E Khatamzas, C J Pitcher, T Bunde, N Persaud, W Trigona, T M Fu, E Sinclair, B M Bredt, J M McCune, V C Maino, F Kern, L J Picker |
Journal of Immunological Methods | 2001 |
Genetically modified immunocompetent cells in HIV infection
G Palù, GL Pira, F Gennari, D Fenoglio, C Parolin, F Manca |
Gene Therapy | 2001 |
Interdisziplinäre klinische Rheumatologie
H Zeidler, J Zacher, F Hiepe |
2001 | |
Functional Heterogeneity of Cytokines and Cytolytic Effector Molecules in Human CD8 + T Lymphocytes
JK Sandberg, NM Fast, DF Nixon |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Comparative Analysis of Human Cytomegalovirus-Specific CD4 + T-Cell Frequency and Lymphoproliferative Response in Human Immunodeficiency Virus-Positive Patients
G Piccinini, G Comolli, E Genini, D Lilleri, R Gulminetti, R Maccario, MG Revello, G Gerna |
Clinical and diagnostic laboratory immunology | 2001 |
Tetramer-based quantification of cytomegalovirus (CMV)–specific CD8+ T lymphocytes in T-cell–depleted stem cell grafts and after transplantation may identify patients at risk for progressive CMV infection
JW Gratama, JW van Esser, CH Lamers, C Tournay, B Löwenberg, RL Bolhuis, JJ Cornelissen |
Blood | 2001 |
Ex Vivo Stimulation and Expansion of both CD4 + and CD8 + T Cells from Peripheral Blood Mononuclear Cells of Human Cytomegalovirus-Seropositive Blood Donors by Using a Soluble Recombinant Chimeric Protein, IE1-pp65
J Vaz-Santiago, J Lulé, P Rohrlich, C Jacquier, N Gibert, EL Roy, D Betbeder, JL Davignon, C Davrinche |
Journal of virology | 2001 |
Gamma Interferon Expression in CD8 + T Cells Is a Marker for Circulating Cytotoxic T Lymphocytes That Recognize an HLA A2-Restricted Epitope of Human Cytomegalovirus Phosphoprotein pp65
SA Ghanekar, LE Nomura, MA Suni, LJ Picker, HT Maecker, VC Maino |
Clinical and diagnostic laboratory immunology | 2001 |
EBV-Specific CD8 + T Cell Memory: Relationships Between Epitope Specificity, Cell Phenotype, and Immediate Effector Function
AD Hislop, NH Gudgeon, MF Callan, C Fazou, H Hasegawa, M Salmon, AB Rickinson |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Clonotypic Structure of the Human CD4 + Memory T Cell Response to Cytomegalovirus
AD Bitmansour, SL Waldrop, CJ Pitcher, E Khatamzas, F Kern, VC Maino, LJ Picker |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Ex Vivo IFN-γ Secretion by Circulating CD8 T Lymphocytes: Implications of a Novel Approach for T Cell Monitoring in Infectious and Malignant Diseases
MJ Pittet, A Zippelius, DE Speiser, M Assenmacher, P Guillaume, D Valmori, D Liénard, F Lejeune, JC Cerottini, P Romero |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine
RR Amara, F Villinger, JD Altman, SL Lydy, SP O'Neil, SI Staprans, DC Montefiori, Y Xu, JG Herndon, LS Wyatt, MA Candido, NL Kozyr, PL Earl, JM Smith, HL Ma, BD Grimm, ML Hulsey, J Miller, HM McClure, JM McNicholl, B Moss, HL Robinson |
Science | 2001 |
Development of virus-specific CD4+ T cells during primary cytomegalovirus infection
RJ Rentenaar, LE Gamadia, N DerHoek, FN van Diepen, R Boom, JF Weel, PM Dillen, RA van Lier, IJ Berge |
Journal of Clinical Investigation | 2000 |
Durchflußzytometrie in der Klinischen Diagnostik. Positionspapier der Arbeitsgruppe Durchflußzytometrie und Quantitative Mikroskopie der Deutschen Gesellschaft für Klinische Chemie und Deutschen Gesellschaft für Laboratoriumsmedizin
U Sack, G Rothe, S Barlage, R Gruber, D Kabelitz, TO Kleine, A Lun, H Renz, A Ruf, G Schmitz |
LaboratoriumsMedizin | 2000 |
Parameters Influencing Measurement of the Gag Antigen-Specific T-Proliferative Response to HIV Type 1 Infection
DS Schiller, JM Binley, KH Roux, CS Adamson, IM Jones, HG Krausslich, A Hurley, M Markowitz, JP Moore |
AIDS Research and Human Retroviruses | 2000 |
Flow cytometric analysis of peptide binding to major histocampatibility complex class I for hepatitis C virus core T-cell epitopes
S Schweitzer, AM Schneiders, B Langhans, W Kraas, G Jung, O Vidalin, G Inchauspe, T Sauerbruch, U Spengler |
Cytometry | 2000 |
Longitudinal Changes in CD4+T Cell Antigen Receptor Diversity and Naive/Memory Cell Phenotype during 9 to 26 Months of Antiretroviral Therapy of HIV-Infected Patients
JC Gea-Banacloche, L Martino, JM Mican, CW Hallahan, M Baseler, R Stevens, L Lambert, M Polis, HC Lane, M Connors |
AIDS Research and Human Retroviruses | 2000 |
Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapy
S Fleury, GP Rizzardi, A Chapuis, G Tambussi, C Knabenhans, E Simeoni, JY Meuwly, JM Corpataux, A Lazzarin, F Miedema, G Pantaleo |
Proceedings of the National Academy of Sciences | 2000 |
Monitoring of antigen-specific cytolytic T lymphocytes in cancer patients receiving immunotherapy
TL Whiteside |
Clinical and diagnostic laboratory immunology | 2000 |
Quantification of the number of cytotoxic T cells specific for an immunodominant HCV-specific CTL epitope primed by DNA immunization
AY Lee, NK Polakos, GR Otten, JB Ulmer, M Houghton, X Paliard |
Vaccine | 2000 |
Enhancement of HIV Type 1 Antigen-Specific CD4+T Cell Memory in Subjects with Chronic HIV Type 1 Infection Receiving an HIV Type 1 Immunogen
VC Maino, MA Suni, SB Wormsley, DJ Carlo, MA Wallace, RB Moss |
AIDS Research and Human Retroviruses | 2000 |
CD30 expression on circulating memory CD4+T cells as a Th2-dominated situation in patients with atopic dermatitis
J Yamamoto, Y Adachi, Y Onoue, H Kanegane, T Miyawaki, M Toyoda, T Seki, M Morohashi |
Allergy | 2000 |
Complex cytokine responses to hepatitis B surface antigen and tetanus toxoid in responders, nonresponders and subjects naive to hepatitis B surface antigen
CE Larsen, J Xu, S Lee, DP Dubey, G Uko, EJ Yunis, CA Alper |
Vaccine | 2000 |
Mistaken self, a novel model that links microbial infections with myelin-directed autoimmunity in multiple sclerosis
JM van Noort, JJ Bajramovic, AC Plomp, MJ van Stipdonk |
Journal of Neuroimmunology | 2000 |
Effect of Cryopreservation on Measurement of Cytomegalovirus-Specific Cellular Immune Responses in HIV-Infected Patients
A Weinberg, DA Wohl, DG Brown, GB Pott, L Zhang, MG Ray, C der Horst |
JAIDS Journal of Acquired Immune Deficiency Syndromes | 2000 |
Flow cytometric visualisation of cytokine production by CD3-CD56+ NK cells and CD3+CD56+ NK-T cells in whole blood
R Mendes, KV Bromelow, M Westby, J Galea-Lauri, IE Smith, ME O'Brien, BE Souberbielle |
Cytometry | 2000 |
Optimization of whole blood antigen-specific cytokine assays for CD4+ T cells
LE Nomura, JM Walker, HT Maecker |
Cytometry | 2000 |
Assessment of donor T-cell function in cellular blood components by the CD69 induction assay: effects of storage, gamma radiation, and photochemical treatment
E Fiebig, DF Hirschkorn, VC Maino, JA Grass, L Lin, MP Busch |
Transfusion | 2000 |
Antigen-Dependent Cytokine mRNA Expression by Individual Rhesus Macaque T Helper Cells by Flow Cytometry
J Arredondo, FX Lü, F Villinger, MB McChesney, JR McGhee, CJ Miller |
Cellular Immunology | 2000 |
Analysis of the antigen-specific T cell response in reactive arthritis by flow cytometry
A Thiel, P Wu, R Lauster, J Braun, A Radbruch, J Sieper |
Arthritis & Rheumatism | 2000 |
The CD4+ T cell response to HIV-1
LJ Picker, VC Maino |
Current Opinion in Immunology | 2000 |
Intratumoral Administration of Adenoviral Interleukin 7 Gene-Modified Dendritic Cells Augments Specific Antitumor Immunity and Achieves Tumor Eradication
PW Miller, S Sharma, M Stolina, LH Butterfield, J Luo, Y Lin, M Dohadwala, RK Batra, L Wu, JS Economou, SM Dubinett |
Human Gene Therapy | 2000 |
Progressive Reduction of CMV-Specific CD4+ T Cells in HIV-1 Infected Individuals During Antiretroviral Therapy
V Grosse, A Schulte, K Weber, M Mendila, R Jacobs, RE Schmidt, H Heiken |
Immunobiology | 2000 |
Direct Measurement of CD8+ T Cell Responses in Macaques Infected with Simian Immunodeficiency Virus
SM Donahoe, WJ Moretto, RV Samuel, KJ Metzner, PA Marx, T Hanke, RI Connor, DF Nixon |
Virology | 2000 |
Immunological benefits of antiretroviral therapy in very early stages of asymptomatic chronic HIV-1 infection
M Plana, F García, T Gallart, C Tortajada, A Soriano, E Palou, MJ Maleno, JJ Barceló, C Vidal, A Cruceta, JM Miró, JM Gatell |
AIDS | 2000 |
Tumor Antigens in Thoracic Malignancy
SM Dubinett, RK Batra, PW Miller, S Sharma |
American journal of respiratory cell and molecular biology | 2000 |
A novel sensitive approach for frequency analysis of measles virus-specific memory T-lymphocytes in healthy adults with a childhood history of natural measles
S Niewiesk, A Rauch, HW Kreth, E Kämpgen, R Nanan |
Journal of General Virology | 2000 |
Rapid whole blood analysis of virus-specific CD4 and CD8 T cell responses in persistent HIV infection:
M Sester, U Sester, H Köhler, T Schneider, L Deml, R Wagner, N Mueller-Lantzsch, HW Pees, A Meyerhans |
AIDS | 2000 |
Reconstitution of lymphocyte subpopulations after paediatric bone marrow transplantation
E Vries, MJ Tol, RL Bergh, JL Waaijer, MM Dam, J Hermans, JM Vossen |
Bone Marrow Transplantation | 2000 |
Status of Cytomegalovirus Prevention and Treatment in 2000
JA Zaia, JG Sissons, S Riddell, DJ Diamond, MR Wills, AJ Carmichael, MP Weekes, M Gandhi, CL Rosa, M Villacres, S Lacey, S Markel, J Sun |
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program | 2000 |
Single-Cytokine-Producing CD4 Memory Cells Predominate in Type 1 and Type 2 Immunity
AY Karulin, MD Hesse, M Tary-Lehmann, PV Lehmann |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
B Lymphoblastoid Cell Lines as Efficient APC to Elicit CD8 + T Cell Responses Against a Cytomegalovirus Antigen
Q Sun, RL Burton, LJ Dai, WJ Britt, KG Lucas |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
HIV Gag mRNA Transfection of Dendritic Cells (DC) Delivers Encoded Antigen to MHC Class I and II Molecules, Causes DC Maturation, and Induces a Potent Human In Vitro Primary Immune Response
D Weissman, H Ni, D Scales, A Dude, J Capodici, K McGibney, A Abdool, SN Isaacs, G Cannon, K Karikó |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
Multispecific CD4 + T Cell Response to a Single 12-mer Epitope of the Immunodominant Heat-Shock Protein 60 of Yersinia enterocolitica in Yersinia -Triggered Reactive Arthritis: Overlap with the B27-Restricted CD8 Epitope, Functional Properties, and Epitope Presentation by Multiple DR Alleles
AK Mertz, P Wu, T Sturniolo, D Stoll, M Rudwaleit, R Lauster, J Braun, J Sieper |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
CD3ζ and CD28 down-modulation on CD8 T cells during viral infection
LA Trimble, LW Kam, RS Friedman, Z Xu, J Lieberman |
Blood | 2000 |
Human Immunodeficiency Virus-Specific Circulating CD8 T Lymphocytes Have Down-Modulated CD3ζ and CD28, Key Signaling Molecules for T-Cell Activation
LA Trimble, P Shankar, M Patterson, JP Daily, J Lieberman |
Journal of virology | 2000 |
Tumor-specific recognition of human myeloma cells by idiotype-induced CD8+ T cells
Y Li, M Bendandi, Y Deng, C Dunbar, N Munshi, S Jagannath, LW Kwak, HK Lyerly |
Blood | 2000 |
Human Immunodeficiency Virus Type 1 Envelope Epitope-Specific CD4 + T Lymphocytes in Simian/Human Immunodeficiency Virus-Infected and Vaccinated Rhesus Monkeys Detected Using a Peptide-Major Histocompatibility Complex Class II Tetramer
MJ Kuroda, JE Schmitz, C Lekutis, CE Nickerson, MA Lifton, G Franchini, JM Harouse, C Cheng-Mayer, NL Letvin |
Journal of virology | 2000 |
Detection and Quantification of CD4 + T Cells with Specificity for a New Major Histocompatibility Complex Class II-Restricted Influenza A Virus Matrix Protein Epitope in Peripheral Blood of Influenza Patients
T Linnemann, G Jung, P Walden |
Journal of virology | 2000 |
Immunofluorescence analysis of T-cell responses in health and disease
H T Maecker, V C Maino, L J Picker |
Journal of Clinical Immunology | 2000 |
Recent developments in flow cytometry
A Scheffold, F Kern |
Journal of Clinical Immunology | 2000 |
Increased frequency of antigen-specific CD8+ cytotoxic T lymphocytes infiltrating an Epstein-Barr virus–associated gastric carcinoma
K Kuzushima, S Nakamura, T Nakamura, Y Yamamura, N Yokoyama, M Fujita, T Kiyono, T Tsurumi |
Journal of Clinical Investigation | 1999 |
Major peptide autoepitopes for nucleosome-specific T cells of human lupus
L Lu, A Kaliyaperumal, DT Boumpas, SK Datta |
Journal of Clinical Investigation | 1999 |
Lymphocyte Proliferation Assays May Underestimate Antigen Responsiveness in Human Immunodeficiency Virus Infection
AH Patki, SF Purvis, HJ Meyerson, MM Lederman |
Clinical Immunology | 1999 |
Cytomegalovirus retinitis after the initiation of highly active antiretroviral therapy: a 2 year prospective study
SM Mitchell, WL Membrey, MS Youle, A Obi, S Worrell, BG Gazzard |
The British journal of ophthalmology | 1999 |
Frequency and characterization of antigen-specific IL-4– and IL-13– producing basophils and T cells in peripheral blood of healthy and asthmatic subjects
G Devouassoux, B Foster, LM Scott, DD Metcalfe, C Prussin |
Journal of Allergy and Clinical Immunology | 1999 |
HAART in HIV-infected patients: restoration of antigen-specific CD4 T-cell responses in vitro is correlated with CD4 memory T-cell reconstitution, whereas improvement in delayed type hypersensitivity is related to a decrease in viraemia
T Wendland, H Furrer, PL Vernazza, K Frutig, A Christen, L Matter, R Malinverni, WJ Pichler |
AIDS | 1999 |
Antigen-specific cytokine response to hepatitis C virus core epitopes in HIV/hepatitis C virus-coinfected patients
RP Woitas, JK Rockstroh, Beier, G Jung, B Kochan, B Matz, HH Brackmann, T Sauerbruch, U Spengler |
AIDS | 1999 |
Mechanisms of human cytomegalovirus (HCMV) (re)activation and its impact on organ transplant patients
P Reinke, S Prosch, F Kern, HD Volk |
Transplant Infectious Disease | 1999 |
Enrichment and detection of live antigen-specific CD4+ and CD8+ T cells based on cytokine secretion
H Brosterhus, S Brings, H Leyendeckers, RA Manz, S Miltenyi, A Radbruch, M Assenmacher, J Schmitz |
European Journal of Immunology | 1999 |
Donor cell induced CD69 expression and intracellular IL-2 and IL-4 production by peripheral blood lymphocytes isolated from kidney transplant recipients
TG Paglieroni, R Perez, S Katznelson, K Muto, T Chang, S Scott, MR MacKenzie, PV Holland |
Human Immunology | 1999 |
Flow cytometric detection of antigen-specific cytokine responses in lung T cells in a murine model of pulmonary inflammation
GE Winterrowd, JE Chin |
Journal of Immunological Methods | 1999 |
HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression
CJ Pitcher, C Quittner, DM Peterson, M Connors, RA Koup, VC Maino, LJ Picker |
Nature Medicine | 1999 |
Interleukin-4 Diminishes CD8 + Respiratory Syncytial Virus-Specific Cytotoxic T-Lymphocyte Activity In Vivo
S Aung, YW Tang, BS Graham |
Journal of virology | 1999 |
Rapid Determination of Epstein-Barr Virus–Specific CD8+T-Cell Frequencies by Flow Cytometry
K Kuzushima, Y Hoshino, K Fujii, N Yokoyama, M Fujita, T Kiyono, H Kimura, T Morishima, Y Morishima, T Tsurumi |
Blood | 1999 |
CMV Retinitis and the Controversies Associated with Highly Active Antiretroviral Therapy and the Immune Recovery Hypothesis
JB Reed, LS Morse |
AIDS Patient Care and STDs | 1998 |
Restoration of cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and highly active antiretroviral therapy in individuals infected with HIV-1
KV Komanduri, MN Viswanathan, ED Wieder, DK Schmidt, BM Bredt, MA Jacobson, JM McCune |
Nature Medicine | 1998 |
Single-cell analysis of lymphokine imbalance in asymptomatic HIV-1 infection: evidence for a major alteration within the CD8+ T cell subset
AE Sousa, RM Victorino |
Clinical & Experimental Immunology | 1998 |
Multiple modes of cellular activation and virus transmission in HIV infection: a role for chronically and latently infected cells in sustaining viral replication
Z Grossman, MB Feinberg, WE Paul |
Proceedings of the National Academy of Sciences | 1998 |
Dual effect of interleukin 4 on HIV-1 expression: implications for viral phenotypic switch and disease progression
A Valentin, W Lu, M Rosati, R Schneider, J Albert, A Karlsson, GN Pavlakis |
Proceedings of the National Academy of Sciences | 1998 |
Cytomegalovirus-specific IFNγ and IL-4 are produced by antigen expanded human blood lymphocytes from seropositive volunteers
EG Kallas, K Reynolds, J Andrews, T Fitzgerald, M Kasper, M Menegus, TG Evans |
Immunology Letters | 1998 |
T-cell epitope mapping by flow cytometry
F Kern, IP Surel, C Brock, B Freistedt, H Radtke, A Scheffold, R Blasczyk, P Reinke, J Schneider-Mergener, A Radbruch, P Walden, HD Volk |
Nature Medicine | 1998 |
Ocular Manifestations of HIV Infection
ET Cunningham, TP Margolis |
New England Journal of Medicine | 1998 |
Prevention of Acute Allograft Rejection by Antibody Targeting of TIRC7, a Novel T Cell Membrane Protein
N Utku, T Heinemann, SG Tullius, GC Bulwin, S Beinke, RS Blumberg, F Beato, J Randall, R Kojima, L Busconi, ES Robertson, R Schülein, HD Volk, EL Milford, SR Gullans |
Immunity | 1998 |
Lack of T-cell proliferative response to HIV-1 antigens after 1 year of highly active antiretroviral treatment in early HIV-1 disease
M Plana, F Garcia, T Gallart, JM Miró, JM Gatell |
The Lancet | 1998 |
Detection of antigen-specific T cell cytokine expression in whole blood by flow cytometry
MA Suni, LJ Picker, VC Maino |
Journal of Immunological Methods | 1998 |
Rapid assessment of antigen induced cytokine expression in memory T cells by flow cytometry
VC Maino |
Veterinary Immunology and Immunopathology | 1998 |
Dual effect of interleukin 4 on HIV-1 expression: Implications for viral phenotypic switch and disease progression
A Valentin, W Lu, M Rosati, R Schneider, J Albert, A Karlsson, GN Pavlakis |
Proceedings of the National Academy of Sciences | 1998 |
Multiple modes of cellular activation and virus transmission in HIV infection: A role for chronically and latently infected cells in sustaining viral replication
Z Grossman, MB Feinberg, WE Paul |
Proceedings of the National Academy of Sciences | 1998 |
Novel methods to monitor antigen-specific cytotoxic T-cell responses in cancer immunotherapy
P Romero, JC Cerottini, GA Waanders |
Molecular Medicine Today | 1998 |
Intestinal Intraepithelial Lymphocytes Are Primed for Gamma Interferon and MIP-1β Expression and Display Antiviral Cytotoxic Activity despite Severe CD4 + T-Cell Depletion in Primary Simian Immunodeficiency Virus Infection
JJ Mattapallil, Z Smit-McBride, M McChesney, S Dandekar |
Journal of virology | 1998 |
Simultaneous detection of DNA synthesis and cytokine production in staphylococcal enterotoxin B activated CD4+ T lymphocytes by flow cytometry
BA Mehta, VC Maino |
Journal of Immunological Methods | 1997 |