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Citations to this article

Skeletal muscle membrane lipid composition is related to adiposity and insulin action.
D A Pan, … , C Bogardus, L H Storlien
D A Pan, … , C Bogardus, L H Storlien
Published December 1, 1995
Citation Information: J Clin Invest. 1995;96(6):2802-2808. https://doi.org/10.1172/JCI118350.
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Research Article Article has an altmetric score of 9

Skeletal muscle membrane lipid composition is related to adiposity and insulin action.

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Abstract

The cellular basis of insulin resistance is still unknown; however, relationships have been demonstrated between insulin action in muscle and the fatty acid profile of the major membrane structural lipid (phospholipid). The present study aimed to further investigate the hypothesis that insulin action and adiposity are associated with changes in the structural lipid composition of the cell. In 52 adult male Pima Indians, insulin action (euglycemic clamp), percentage body fat (pFAT; underwater weighing), and muscle phospholipid fatty acid composition (percutaneous biopsy of vastus lateralis) were determined. Insulin action (high-dose clamp; MZ) correlated with composite measures of membrane unsaturation (% C20-22 polyunsaturated fatty acids [r= 0.463, P < 0.001], unsaturation index [r= -0.369, P < 0.01]), a number of individual fatty acids and with delta5 desaturase activity (r= 0.451, P < 0.001). pFAT (range 14-53%) correlated with a number of individual fatty acids and delta5 desaturase activity (r= -0.610, P < 0.0001). Indices of elongase activity (r= -0.467, P < 0.001), and delta9 desaturase activity (r= 0.332, P < 0.05) were also related to pFAT but not insulin action. The results demonstrate that delta5 desaturase activity is independently related to both insulin resistance and obesity. While determining the mechanisms underlying this relationship is important for future investigations, strategies aimed at restoring "normal" enzyme activities, and membrane unsaturation, may have therapeutic importance in the "syndromes of insulin resistance."

Authors

D A Pan, S Lillioja, M R Milner, A D Kriketos, L A Baur, C Bogardus, L H Storlien

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Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 Total
Citations: 1 2 2 2 6 9 3 7 9 5 6 4 9 11 8 12 16 14 10 9 8 7 9 6 12 8 10 7 3 215
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Citations to this article in year 2017 (7)

Title and authors Publication Year
Association of muscle lipidomic profile with high-fat diet-induced insulin resistance across five mouse strains
MK Montgomery, SH Brown, TW Mitchell, AC Coster, GJ Cooney, N Turner
Scientific Reports 2017
Changes in the plasma membrane in metabolic disease: impact of the membrane environment on G protein-coupled receptor structure and function: Membrane impact on receptor function
AJ Desai, LJ Miller
British Journal of Pharmacology 2017
Membrane lipid alterations in the metabolic syndrome and the role of dietary oils
JS Perona
Biochimica et Biophysica Acta (BBA) - Biomembranes 2017
Intermuscular Adipose Tissue Content and Intramyocellular Lipid Fatty Acid Saturation Are Associated with Glucose Homeostasis in Middle-Aged and Older Adults
JE Kim, K Dunville, J Li, JX Cheng, TB Conley, CS Couture, WW Campbell
Endocrinology and Metabolism 2017
Iodine values of adipose tissue varied among breeds of pigs and were correlated with pork quality
ED Testroet, CL Yoder, A Testroet, C Reynolds, MR O'Neil, SM Lei, DC Beitz, TJ Baas
Adipocyte 2017
Serum Fatty Acids, Desaturase Activities and Abdominal Obesity – A Population-Based Study of 60-Year Old Men and Women
ZD Alsharari, U Risérus, K Leander, P Sjögren, AC Carlsson, M Vikström, F Laguzzi, B Gigante, T Cederholm, UD Faire, ML Hellénius, M Marklund, A Catapano
PloS one 2017
Associations Among Fatty Acids, Desaturase and Elongase, and Insulin Resistance in Children
LM Beccarelli, RE Scherr, JW Newman, AG Borkowska, IJ Gray, JD Linnell, CL Keen, HM Young
Journal of the American College of Nutrition 2017

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