Cross-reactive anti-DNA antibody idiotypes have been identified on tissue-bound immunoglobulins in a study of renal biopsies from 26 systemic lupus erythematosus (SLE) patients. 12 (46%) biopsies were shown to have one or both the idiotypes tested for by anti-idiotypic reagents. The idiotypes were identified in the glomerular basement membrane, the mesangial cell cytoplasm, and in focal tuft proliferations. In contrast, in none of 24 immunoglobulin-positive disease control biopsies could either idiotype be demonstrated. Blocking studies in two patients indicated that the idiotypes were on anti-DNA antibodies. These findings indicate that some tissue-bound auto-antibodies are derived from related families of high-frequency germ line genes that are expressed in SLE patients. The potential role of anti-idiotypic therapy in SLE is discussed.
D A Isenberg, C Collins
Title and authors | Publication | Year |
---|---|---|
Molecular basis of 9G4 B cell autoreactivity in human systemic lupus erythematosus
C Richardson, AS Chida, D Adlowitz, L Silver, E Fox, SA Jenks, E Palmer, Y Wang, J Heimburg-Molinaro, QZ Li, C Mohan, R Cummings, C Tipton, I Sanz |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
Dubois' Lupus Erythematosus and Related Syndromes
JC Crispín, GC Tsokos |
Dubois' Lupus Erythematosus and Related Syndromes | 2013 |
Natural antibodies to nucleic acids
VN Buneva, MA Krasnorutskii, GA Nevinsky |
Biochemistry (Moscow) | 2013 |
Discoveries in the pathophysiology of neuropsychiatric lupus erythematosus: consequences for therapy
T Gono, Y Kawaguchi, H Yamanaka |
BMC Medicine | 2013 |
16/6-idiotype expressing antibodies induce brain inflammation and cognitive impairment in mice: the mosaic of central nervous system involvement in lupus
S Kivity, A Katzav, MT Arango, M Landau-Rabi, Y Zafrir, N Agmon-Levin, M Blank, JM Anaya, E Mozes, J Chapman, Y Shoenfeld |
BMC Medicine | 2013 |
Neuropsychiatric systemic lupus erythematosus: pathophysiology and the future of treatment
T Gono, T Takarada, Y Katsumata, Y Kawaguchi, Y Yoneda, H Yamanaka |
International Journal of Clinical Rheumatology | 2013 |