Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Detection of cross-reactive anti-DNA antibody idiotypes on renal tissue-bound immunoglobulins from lupus patients.
D A Isenberg, C Collins
D A Isenberg, C Collins
Published July 1, 1985
Citation Information: J Clin Invest. 1985;76(1):287-294. https://doi.org/10.1172/JCI111959.
View: Text | PDF
Research Article Article has an altmetric score of 3

Detection of cross-reactive anti-DNA antibody idiotypes on renal tissue-bound immunoglobulins from lupus patients.

  • Text
  • PDF
Abstract

Cross-reactive anti-DNA antibody idiotypes have been identified on tissue-bound immunoglobulins in a study of renal biopsies from 26 systemic lupus erythematosus (SLE) patients. 12 (46%) biopsies were shown to have one or both the idiotypes tested for by anti-idiotypic reagents. The idiotypes were identified in the glomerular basement membrane, the mesangial cell cytoplasm, and in focal tuft proliferations. In contrast, in none of 24 immunoglobulin-positive disease control biopsies could either idiotype be demonstrated. Blocking studies in two patients indicated that the idiotypes were on anti-DNA antibodies. These findings indicate that some tissue-bound auto-antibodies are derived from related families of high-frequency germ line genes that are expressed in SLE patients. The potential role of anti-idiotypic therapy in SLE is discussed.

Authors

D A Isenberg, C Collins

×

Total citations by year

Year: 2018 2015 2013 2011 2010 2006 2004 2002 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1981 1960 Total
Citations: 1 1 6 1 1 1 4 1 2 1 4 1 4 10 7 3 12 16 16 15 8 5 1 1 1 1 124
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2013 (6)

Title and authors Publication Year
Molecular basis of 9G4 B cell autoreactivity in human systemic lupus erythematosus
C Richardson, AS Chida, D Adlowitz, L Silver, E Fox, SA Jenks, E Palmer, Y Wang, J Heimburg-Molinaro, QZ Li, C Mohan, R Cummings, C Tipton, I Sanz
Journal of immunology (Baltimore, Md. : 1950) 2013
Dubois' Lupus Erythematosus and Related Syndromes
JC Crispín, GC Tsokos
Dubois' Lupus Erythematosus and Related Syndromes 2013
Natural antibodies to nucleic acids
VN Buneva, MA Krasnorutskii, GA Nevinsky
Biochemistry (Moscow) 2013
Discoveries in the pathophysiology of neuropsychiatric lupus erythematosus: consequences for therapy
T Gono, Y Kawaguchi, H Yamanaka
BMC Medicine 2013
16/6-idiotype expressing antibodies induce brain inflammation and cognitive impairment in mice: the mosaic of central nervous system involvement in lupus
S Kivity, A Katzav, MT Arango, M Landau-Rabi, Y Zafrir, N Agmon-Levin, M Blank, JM Anaya, E Mozes, J Chapman, Y Shoenfeld
BMC Medicine 2013
Neuropsychiatric systemic lupus erythematosus: pathophysiology and the future of treatment
T Gono, T Takarada, Y Katsumata, Y Kawaguchi, Y Yoneda, H Yamanaka
International Journal of Clinical Rheumatology 2013

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 2 patents
13 readers on Mendeley
See more details