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Research Article Free access | 10.1172/JCI106356
Harriet Lane Service of the Children's Medical and Surgical Center, and the Department of Obstetrics and Gynecology, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205
Department of Obstetrics and Gynecology of the University of Maryland, School of Medicine, Baltimore, Maryland 21201
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Harriet Lane Service of the Children's Medical and Surgical Center, and the Department of Obstetrics and Gynecology, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205
Department of Obstetrics and Gynecology of the University of Maryland, School of Medicine, Baltimore, Maryland 21201
Find articles by Ances, I. in: JCI | PubMed | Google Scholar
Harriet Lane Service of the Children's Medical and Surgical Center, and the Department of Obstetrics and Gynecology, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205
Department of Obstetrics and Gynecology of the University of Maryland, School of Medicine, Baltimore, Maryland 21201
Find articles by Tapper, A. in: JCI | PubMed | Google Scholar
Harriet Lane Service of the Children's Medical and Surgical Center, and the Department of Obstetrics and Gynecology, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205
Department of Obstetrics and Gynecology of the University of Maryland, School of Medicine, Baltimore, Maryland 21201
Find articles by Weldon, V. in: JCI | PubMed | Google Scholar
Harriet Lane Service of the Children's Medical and Surgical Center, and the Department of Obstetrics and Gynecology, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205
Department of Obstetrics and Gynecology of the University of Maryland, School of Medicine, Baltimore, Maryland 21201
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Harriet Lane Service of the Children's Medical and Surgical Center, and the Department of Obstetrics and Gynecology, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205
Department of Obstetrics and Gynecology of the University of Maryland, School of Medicine, Baltimore, Maryland 21201
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Published July 1, 1970 - More info
The transplacental passage and the production of aldosterone were studied in late pregnancy during a constant infusion of 1,2-aldosterone-3H to mothers at the time of elective cesarean section.
It was found that, while maternal aldosterone crossed the placenta, there was a significant secretion of aldosterone by the fetus. The aldosterone concentration in fetal plasma was 2-12 times higher than that of the corresponding mothers.
Pregnancy had no effect on the metabolic clearance rate of aldosterone, but it increased the rate of production of this steroid. However, the increments that we observed were smaller than those reported in previous reports. The discrepancy was probably due to differences in body posture, our subjects being supine for at least 10 hr at the time of study.