Conversations with Giants in Medicine
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Nuclear Receptors (Apr 2017)
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Hypoxia and Inflammation (Oct 2016)
Extracellular Vesicles (Apr 2016)
HIV (Feb 2016)
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Autoimmunity (Jun 2015)
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OX40 signals death for liver-resident immune cells
In this episode, Xian Li and colleagues demonstrate that stimulation of cell surface receptor OX40 induces pyroptosis in a liver-resident immune cell population.....
Published April 24, 2017
Unravelling differences in arthritis manifestation in mast cell-deficient mice
Peter Nigrovic and colleagues reveal that marrow and stromal context determine the role of mast cells in inflammation and that megakaryocytes can directly mediate inflammation...
Published April 4, 2017
Insight into lupus-associated CD11b mutations
In this episode, Marian Kaplan and Vineet Gupta reveal that lupus-associated mutations in the CD11b-encoding gene reduce CD11b function and that small molecule activation of CD11b ameliorates disease in mouse models of lupus...
Published April 3, 2017
Using proteomics to predict heart disease
In this episode, Manuel Mayr and colleagues use a proteomic approach to identify biomarkers of cardiovascular disease progression...
Published March 20, 2017
Donor tissue-derived exosomes may predict transplant rejection
In this episode, Prashanth Vallabhajosyula and colleagues present evidence that donor-derived exosomes can be used to noninvasively monitor immune-meditated transplant rejection...
Published March 20, 2017
Epigenetic targeting improves metabolic defects in obesity-prone mice
In this episode, Mitchell Lazar and Raymond Soccio discuss their work, which shows that epigenetic modification can rescue genetic metabolic defects...
Published February 27, 2017
Neuroflux sheds light on olfactory sensory neurons
In this episode, Jacob Hooker, Mark Alberts, and Genevieve C. Van de Bittner describe the discovery and characterization of a PET radiotracer that specifically labels olfactory sensory neurons...
Published January 23, 2017
Kisspeptin in the limbic system
In this episode, Waljit Dhillo and colleagues reveal that kisspeptin acts on the limbic system to mediate sexual and emotional brain processing...
Published January 23, 2017
A metabolic approach for retinal degeneration
In this episode, Stephen Tsang and colleagues discuss their study, which shows that upregulation of glycolytic flux specifically in rod photoreceptors improves photoreceptor survival and preserves vision in a mouse model of retinitis pigmentosa...
Published November 14, 2016
Compound delivers a one-two punch to target cancer metabolism
In this episode, Aimee Edinger discusses a recent study from her group, which describes the effects of a sphingolipid-based compound, SH-BC-893, in multiple pre-clinical cancer models.
Published October 20, 2016
SPARCL1 and the colorectal carcinoma microenvironment
In this episode, Michael Stürzl, Elisabeth Naschberger, and Andrea Liebl discuss their study, which identifies endothelial cell secretion of the protein SPARCL1 as an important regulator of colorectal cancer aggressiveness...
Published October 10, 2016
Vascular stiffness drives metabolic alterations in pulmonary hypertension
In this episode, Stephen Chan discusses work from his laboratory that links increased vascular stiffness to altered glutamine metabolism in the pathogenesis of pulmonary hypertension.
Published August 22, 2016
Calpain-6 mediates atherogenic macrophage function
In this episode, Takuro Miyazaki and colleagues reveal that elevation of calpain-6 in macrophages promotes atherogenic functions by disrupting CWC22/EJC/Rac1 signaling.
Published August 15, 2016
Local TNF mediates free cholesterol–dependent podocyte injury
In this episode, Alessia Fornoni reveals that TNF promotes free cholesterol–dependent podocyte apoptosis via an NFATc1/ ABCA1-dependent mechanism.
Published August 2, 2016
p21 contributes to macrophage switching during sepsis
In this episode, Dimitrios Balomenos and Gorjana Rackov discuss their recent study, which shows that p21 is instrumental in macrophage switching from a pro-inflammatory to an immunosuppressive state during sepsis.
Published July 18, 2016
Insight into pathologic epidermal-immune interactions in psoriasis
In this episode, Peter Marinkovich and Mårten Winge discuss their work, which shows that hyperactivation of RAC1 in the skin drives pathogenic interactions between the epidermis and the immune system in psoriasis.
Published June 13, 2016
Breaking down skin barrier function in mice with pruritic dermatitis
In this episode, Hisahiro Yoshida describes the development and characterization of a strain of mice that exhibit progressive pruritic dermatitis...
Published April 25, 2016
Unraveling the role of sex in renal ischemia tolerance
In this episode, Matthew Levine and David Aufhauser discuss their work, which reveals sex-specific effects on renal ischemia tolerance and transplantation outcomes...
Published April 18, 2016
Increasing drug delivery through the blood-brain barrier
In this episode, Margaret Bynoe reveals that activation of the A2A adenosine receptor (A2A AR) with the FDA-approved agonist Lexiscan reversibly reduced expression of the drug efflux transporters P-glycoprotein and BCRP1.
Published April 4, 2016
TLR9 activation in nonalcoholic steatohepatitis
Nonalcoholic steatohepatitis (NASH) is the most common liver disease in the US and can lead to cirrhosis, cancer, and death; however, the drivers of NASH development are poorly understood. In this episode, Wajahat Mehal and colleagues reveal that le...
Published January 25, 2016
Copyright © 2017
American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)
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