Therapeutic manipulation of angiogenesis would be desirable for the treatment of a variety of diseases, including cancer and heart disease. This short series focuses this therapeutic potential and specifically on integrins and matrix metalloproteinases as potential targets.
Published May 1999
Signal transduction depends on a series of direct interaction between molecules, both on the cell surface and intracellularly. The series discusses the molecular basis for the formation of transient protein complexes.
Published March 1999
This series summarizes the current knowledge of the molecular basis for cystic fibrosis and reviews the state of gene therapeutic and pharmacological strategies for therapeutic intervention.
Published February 1999