[HTML][HTML] Challenges facing islet transplantation for the treatment of type 1 diabetes mellitus
KI Rother, DM Harlan - The Journal of clinical investigation, 2004 - Am Soc Clin Investig
KI Rother, DM Harlan
The Journal of clinical investigation, 2004•Am Soc Clin InvestigIslet transplantation represents a most impressive recent advance in the search for a type 1
diabetes mellitus cure. While several hundred patients have achieved at least temporary
insulin independence after receiving the islet “mini-organs”(containing insulin-producing β
cells), very few patients remain insulin independent beyond 4 years after transplantation. In
this review, we describe historic as well as technical details about the procedure and
provide insight into clinical and basic research efforts to overcome existing hurdles for this …
diabetes mellitus cure. While several hundred patients have achieved at least temporary
insulin independence after receiving the islet “mini-organs”(containing insulin-producing β
cells), very few patients remain insulin independent beyond 4 years after transplantation. In
this review, we describe historic as well as technical details about the procedure and
provide insight into clinical and basic research efforts to overcome existing hurdles for this …
Islet transplantation represents a most impressive recent advance in the search for a type 1 diabetes mellitus cure. While several hundred patients have achieved at least temporary insulin independence after receiving the islet “mini-organs” (containing insulin-producing β cells), very few patients remain insulin independent beyond 4 years after transplantation. In this review, we describe historic as well as technical details about the procedure and provide insight into clinical and basic research efforts to overcome existing hurdles for this promising therapy.
The Journal of Clinical Investigation