[HTML][HTML] Translation factor eif4e rescues cells from myc-dependent apoptosis by inhibiting cytochromec release
S Li, T Takasu, DM Perlman, MS Peterson… - Journal of Biological …, 2003 - ASBMB
Eukaryotic translation initiation factor 4E (eIF4E) markedly reduces cellular susceptibility to
apoptosis. However, the mechanism by which the translation apparatus operates on the
cellular apoptotic machinery remains uncertain. Here we show that eIF4E-mediated rescue
from Myc-dependent apoptosis is accompanied by inhibition of mitochondrial cytochrome
crelease. Experiments achieving gain and loss of function demonstrate that eIF4E-mediated
rescue is governed by pretranslational and translational activation of bcl-x as well as by …
apoptosis. However, the mechanism by which the translation apparatus operates on the
cellular apoptotic machinery remains uncertain. Here we show that eIF4E-mediated rescue
from Myc-dependent apoptosis is accompanied by inhibition of mitochondrial cytochrome
crelease. Experiments achieving gain and loss of function demonstrate that eIF4E-mediated
rescue is governed by pretranslational and translational activation of bcl-x as well as by …