[HTML][HTML] Distinct pathways regulate proapoptotic Nix and BNip3 in cardiac stress
AS Gálvez, EW Brunskill, Y Marreez, BJ Benner… - Journal of biological …, 2006 - ASBMB
Up-regulation of myocardial Nix and BNip3 is associated with apoptosis in cardiac
hypertrophy and ischemia, respectively. To identify mechanisms of gene regulation for these
critical cardiac apoptosis effectors, the determinants of Nix and BNip3 promoter activation
were elucidated by luciferase reporter gene expression in neonatal rat cardiac myocytes.
BNip3 transcription was increased by hypoxia but not by phenylephrine (10 μm),
angiotensin II (100 nm), or isoproterenol (10 μm). In contrast, Nix transcription was increased …
hypertrophy and ischemia, respectively. To identify mechanisms of gene regulation for these
critical cardiac apoptosis effectors, the determinants of Nix and BNip3 promoter activation
were elucidated by luciferase reporter gene expression in neonatal rat cardiac myocytes.
BNip3 transcription was increased by hypoxia but not by phenylephrine (10 μm),
angiotensin II (100 nm), or isoproterenol (10 μm). In contrast, Nix transcription was increased …