Parenteral Administration of Medium- but Not Long-Chain Lipid Emulsions May Increase the Risk for Infections by Candida albicans

GJ Wanten, MG Netea, TH Naber, JH Curfs… - Infection and …, 2002 - Am Soc Microbiol
GJ Wanten, MG Netea, TH Naber, JH Curfs, LE Jacobs, TJ Verver-Jansen, BJ Kullberg
Infection and immunity, 2002Am Soc Microbiol
Intravenous administration to volunteers of an emulsion of medium-chain lipids, but not of an
emulsion of pure long-chain lipids or a placebo, increased the growth of Candida albicans in
serum and modulated Candida-induced cytokine production by mononuclear cells in a way
suggesting that medium-chain, but not long-chain, triglycerides increase the risk for
infections by Candida.
Abstract
Intravenous administration to volunteers of an emulsion of medium-chain lipids, but not of an emulsion of pure long-chain lipids or a placebo, increased the growth of Candida albicans in serum and modulated Candida-induced cytokine production by mononuclear cells in a way suggesting that medium-chain, but not long-chain, triglycerides increase the risk for infections by Candida.
American Society for Microbiology