Differential role of programmed death-ligand 1 and programmed death-ligand 2 in regulating the susceptibility and chronic progression of experimental autoimmune …
Abstract Programmed death-1 (PD-1) is a negative costimulatory molecule, and blocking the
interaction of PD-1 with its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC), enhances
autoimmune disease in several animal models. We have studied the role of PD-1 ligands in
disease susceptibility and chronic progression in experimental autoimmune
encephalomyelitis (EAE). In BALB/c mice immunized with myelin oligodendrocyte
glycoprotein (MOG) peptide 35–55, PD-L1 but not PD-L2 blockade significantly increased …
interaction of PD-1 with its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC), enhances
autoimmune disease in several animal models. We have studied the role of PD-1 ligands in
disease susceptibility and chronic progression in experimental autoimmune
encephalomyelitis (EAE). In BALB/c mice immunized with myelin oligodendrocyte
glycoprotein (MOG) peptide 35–55, PD-L1 but not PD-L2 blockade significantly increased …
Differential role of programmed death-ligand 1 [corrected] and programmed death-ligand 2 [corrected] in regulating the susceptibility and chronic progression of …
Programmed death-1 (PD-1) is a negative costimulatory molecule, and blocking the
interaction of PD-1 with its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC), enhances
autoimmune disease in several animal models. We have studied the role of PD-1 ligands in
disease susceptibility and chronic progression in experimental autoimmune
encephalomyelitis (EAE). In BALB/c mice immunized with myelin oligodendrocyte
glycoprotein (MOG) peptide 35-55, PD-L1 but not PD-L2 blockade significantly increased …
interaction of PD-1 with its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC), enhances
autoimmune disease in several animal models. We have studied the role of PD-1 ligands in
disease susceptibility and chronic progression in experimental autoimmune
encephalomyelitis (EAE). In BALB/c mice immunized with myelin oligodendrocyte
glycoprotein (MOG) peptide 35-55, PD-L1 but not PD-L2 blockade significantly increased …