The nucleus raphe interpositus in spinocerebellar ataxia type 3 (Machado–Joseph disease)
U Rüb, ER Brunt, K Gierga, C Schultz… - Journal of Chemical …, 2003 - Elsevier
The nucleus raphe interpositus (RIP) plays an important role in the premotor network for
saccades. Its omnipause neurons gate the activity of the burst neurons for vertical saccades
lying within the rostral interstitial nucleus of the medial longitudinal fascicle and that for
horizontal saccades residing in the caudal subnucleus of the pontine reticular formation. In
the present study we investigated the RIP in five patients with clinically diagnosed and
genetically confirmed spinocerebellar ataxia type 3 (SCA3), also known as Machado …
saccades. Its omnipause neurons gate the activity of the burst neurons for vertical saccades
lying within the rostral interstitial nucleus of the medial longitudinal fascicle and that for
horizontal saccades residing in the caudal subnucleus of the pontine reticular formation. In
the present study we investigated the RIP in five patients with clinically diagnosed and
genetically confirmed spinocerebellar ataxia type 3 (SCA3), also known as Machado …