Tissue-specific adrenergic regulation of the L-type Ca2+ channel CaV1.2
Ca2+ influx through the L-type Ca2+ channel Cav1. 2 triggers each heartbeat. The fight-or-
flight response induces the release of the stress response hormone norepinephrine to
stimulate β-adrenergic receptors, cAMP production, and protein kinase A activity to augment
Ca2+ influx through Cav1. 2 and, consequently, cardiomyocyte contractility. Emerging
evidence shows that Cav1. 2 is regulated by different mechanisms in cardiomyocytes
compared to neurons and vascular smooth muscle cells.
flight response induces the release of the stress response hormone norepinephrine to
stimulate β-adrenergic receptors, cAMP production, and protein kinase A activity to augment
Ca2+ influx through Cav1. 2 and, consequently, cardiomyocyte contractility. Emerging
evidence shows that Cav1. 2 is regulated by different mechanisms in cardiomyocytes
compared to neurons and vascular smooth muscle cells.
Ca2+ influx through the L-type Ca2+ channel Cav1.2 triggers each heartbeat. The fight-or-flight response induces the release of the stress response hormone norepinephrine to stimulate β-adrenergic receptors, cAMP production, and protein kinase A activity to augment Ca2+ influx through Cav1.2 and, consequently, cardiomyocyte contractility. Emerging evidence shows that Cav1.2 is regulated by different mechanisms in cardiomyocytes compared to neurons and vascular smooth muscle cells.
AAAS