Tissue inhibitors of matrix metalloproteinases are elevated in cerebrospinal fluid of neurodegenerative diseases
S Lorenzl, DS Albers, PA LeWitt, JW Chirichigno… - Journal of the …, 2003 - Elsevier
Matrix metalloproteinases (MMPs) are implicated in the pathogenesis of diseases such as
Alzheimer's Disease (AD) and amyotrophic lateral sclerosis (ALS). Increased expression of
MMP-9 and TIMPs has been reported in postmortem AD and ALS brain tissue, as well as in
ALS cerebrospinal fluid (CSF) and plasma. Although individual studies of MMP and TIMP
expression in CSF have included AD and ALS samples, there are no studies comparing the
expression of these proteins between neurodegenerative diseases. We measured the levels …
Alzheimer's Disease (AD) and amyotrophic lateral sclerosis (ALS). Increased expression of
MMP-9 and TIMPs has been reported in postmortem AD and ALS brain tissue, as well as in
ALS cerebrospinal fluid (CSF) and plasma. Although individual studies of MMP and TIMP
expression in CSF have included AD and ALS samples, there are no studies comparing the
expression of these proteins between neurodegenerative diseases. We measured the levels …
