We have previously reported that tissue inhibitor of metalloproteinases-2 (TIMP-2), an
endogenous inhibitor of matrix metalloproteinase, modulates angiogenic responses through
the MMP inhibition-independent activity. In this study, we investigate the molecular
mechanisms of TIMP-2-mediated growth inhibition in response to fibroblast growth factor-2
(FGF-2). Pre-treatment with a protein tyrosine phosphatase inhibitor orthovanadate or
expression of a dominant negative Shp-1 mutant fails to induce TIMP-2 inactivation of FGF-2 …