[HTML][HTML] The extracellular calcium-sensing receptor is required for calcium-induced differentiation in human keratinocytes
CL Tu, W Chang, DD Bikle - Journal of biological Chemistry, 2001 - ASBMB
In cultured keratinocytes, the acute increase of the extracellular calcium concentration above
0.03 mmleads to a rapid increase in intracellular calcium concentration ([Ca 2+] i) and
inositol trisphosphate production and, subsequently, to the expression of differentiation-
related genes. Previous studies demonstrated that human keratinocytes express the full-
length extracellular calcium-sensing receptor (CaR) and an alternatively spliced variant
lacking exon 5 and suggested their involvement in calcium regulation of keratinocyte …
0.03 mmleads to a rapid increase in intracellular calcium concentration ([Ca 2+] i) and
inositol trisphosphate production and, subsequently, to the expression of differentiation-
related genes. Previous studies demonstrated that human keratinocytes express the full-
length extracellular calcium-sensing receptor (CaR) and an alternatively spliced variant
lacking exon 5 and suggested their involvement in calcium regulation of keratinocyte …