Bcl-2 inhibition to overcome resistance to chemo-and immunotherapy
M García-Aranda, E Pérez-Ruiz… - International journal of …, 2018 - mdpi.com
M García-Aranda, E Pérez-Ruiz, M Redondo
International journal of molecular sciences, 2018•mdpi.comAccording to the World Health Organization (WHO), cancer is a leading cause of death
worldwide. The identification of novel targets for cancer treatment is an area of intense work
that has led Bcl-2 over-expression to be proposed as one of the hallmarks of cancer and Bcl-
2 inhibition as a promising strategy for cancer treatment. In this review, we describe the
different pathways related to programmed cell death, the role of Bcl-2 family members in
apoptosis resistance to anti-cancer treatments, and the potential utility of Bcl-2 inhibitors to …
worldwide. The identification of novel targets for cancer treatment is an area of intense work
that has led Bcl-2 over-expression to be proposed as one of the hallmarks of cancer and Bcl-
2 inhibition as a promising strategy for cancer treatment. In this review, we describe the
different pathways related to programmed cell death, the role of Bcl-2 family members in
apoptosis resistance to anti-cancer treatments, and the potential utility of Bcl-2 inhibitors to …
According to the World Health Organization (WHO), cancer is a leading cause of death worldwide. The identification of novel targets for cancer treatment is an area of intense work that has led Bcl-2 over-expression to be proposed as one of the hallmarks of cancer and Bcl-2 inhibition as a promising strategy for cancer treatment. In this review, we describe the different pathways related to programmed cell death, the role of Bcl-2 family members in apoptosis resistance to anti-cancer treatments, and the potential utility of Bcl-2 inhibitors to overcome resistance to chemo- and immunotherapy.
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