Repair of strand breaks by homologous recombination
M Jasin, R Rothstein - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
M Jasin, R Rothstein
Cold Spring Harbor perspectives in biology, 2013•cshperspectives.cshlp.orgIn this review, we discuss the repair of DNA double-strand breaks (DSBs) using a
homologous DNA sequence (ie, homologous recombination [HR]), focusing mainly on yeast
and mammals. We provide a historical context for the current view of HR and describe how
DSBs are processed during HR as well as interactions with other DSB repair pathways. We
discuss the enzymology of the process, followed by studies on DSB repair in living cells.
Whenever possible, we cite both original articles and reviews to aid the reader for further …
homologous DNA sequence (ie, homologous recombination [HR]), focusing mainly on yeast
and mammals. We provide a historical context for the current view of HR and describe how
DSBs are processed during HR as well as interactions with other DSB repair pathways. We
discuss the enzymology of the process, followed by studies on DSB repair in living cells.
Whenever possible, we cite both original articles and reviews to aid the reader for further …
In this review, we discuss the repair of DNA double-strand breaks (DSBs) using a homologous DNA sequence (i.e., homologous recombination [HR]), focusing mainly on yeast and mammals. We provide a historical context for the current view of HR and describe how DSBs are processed during HR as well as interactions with other DSB repair pathways. We discuss the enzymology of the process, followed by studies on DSB repair in living cells. Whenever possible, we cite both original articles and reviews to aid the reader for further studies.
cshperspectives.cshlp.org