[HTML][HTML] RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response
S Liu, J Chu, N Yucer, M Leng, SY Wang… - Journal of Biological …, 2011 - ASBMB
DNA damage response is crucial for maintaining genomic integrity and preventing cancer by
coordinating the activation of checkpoints and the repair of damaged DNA. Central to DNA
damage response are the two checkpoint kinases ATM and ATR that phosphorylate a wide
range of substrates. RING finger and WD repeat domain 3 (RFWD3) was initially identified
as a substrate of ATM/ATR from a proteomic screen. Subsequent studies showed that
RFWD3 is an E3 ubiquitin ligase that ubiquitinates p53 in vitro and positively regulates p53 …
coordinating the activation of checkpoints and the repair of damaged DNA. Central to DNA
damage response are the two checkpoint kinases ATM and ATR that phosphorylate a wide
range of substrates. RING finger and WD repeat domain 3 (RFWD3) was initially identified
as a substrate of ATM/ATR from a proteomic screen. Subsequent studies showed that
RFWD3 is an E3 ubiquitin ligase that ubiquitinates p53 in vitro and positively regulates p53 …