Pathobiology of T-cell and NK-cell lymphomas

EB Bajor-Dattilo, S Pittaluga, ES Jaffe - Best Practice & Research Clinical …, 2013 - Elsevier
T-cell and NK-cell lymphomas are uncommon lymphomas with an aggressive clinical
course. The causes and precise cellular origins of most T-cell lymphomas are still not well
defined. The WHO classification utilizes morphologic and immunophenotypic features in
conjunction with clinical aspects and in some instances genetics to delineate a
prognostically and therapeutically meaningful categorization. The anatomic localization of
neoplastic T-cells and NK-cells parallels in part their proposed normal cellular counterparts …