[HTML][HTML] Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation*♦
A Chakraborty, M Wakamiya… - Journal of Biological …, 2015 - ASBMB
Why mammalian cells possess multiple DNA glycosylases (DGs) with overlapping substrate
ranges for repairing oxidatively damaged bases via the base excision repair (BER) pathway
is a long-standing question. To determine the biological role of these DGs, null animal
models have been generated. Here, we report the generation and characterization of mice
lacking Neil2 (Nei-like 2). As in mice deficient in each of the other four oxidized base-specific
DGs (OGG1, NTH1, NEIL1, and NEIL3), Neil2-null mice show no overt phenotype. However …
ranges for repairing oxidatively damaged bases via the base excision repair (BER) pathway
is a long-standing question. To determine the biological role of these DGs, null animal
models have been generated. Here, we report the generation and characterization of mice
lacking Neil2 (Nei-like 2). As in mice deficient in each of the other four oxidized base-specific
DGs (OGG1, NTH1, NEIL1, and NEIL3), Neil2-null mice show no overt phenotype. However …