Presence and significance of microvesicular steatosis in nonalcoholic fatty liver disease

S Tandra, MM Yeh, EM Brunt, R Vuppalanchi… - Journal of …, 2011 - Elsevier
BACKGROUND & AIMS: Liver biopsies from patients with nonalcoholic fatty liver disease
(NAFLD) sometimes exhibit non-zonal aggregates of hepatocytes with microvesicular
steatosis, but its prevalence and significance are unclear. In this study, we have evaluated
the frequency of microvesicular steatosis and assessed its association with histological
markers of disease severity in a large sample of NAFLD liver biopsies. METHODS: Liver
biopsies from a large cohort of adults who participated in two studies conducted by the …