[HTML][HTML] Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice
I Murano, G Barbatelli, V Parisani, C Latini… - Journal of lipid …, 2008 - ASBMB
Accumulation of visceral fat is a key phenomenon in the onset of obesity-associated
metabolic disorders. Macrophage infiltration induces chronic mild inflammation widely
considered as a causative factor for insulin resistance and eventually diabetes. We
previously showed that> 90% of macrophages infiltrating the adipose tissue of obese
animals and humans are arranged around dead adipocytes, forming characteristic crown-
like structures (CLS). In this study we quantified CLS in visceral and subcutaneous depots …
metabolic disorders. Macrophage infiltration induces chronic mild inflammation widely
considered as a causative factor for insulin resistance and eventually diabetes. We
previously showed that> 90% of macrophages infiltrating the adipose tissue of obese
animals and humans are arranged around dead adipocytes, forming characteristic crown-
like structures (CLS). In this study we quantified CLS in visceral and subcutaneous depots …