[HTML][HTML] The relationship between body mass index, activated protein C resistance and risk of venous thrombosis
SC Christiansen, WM Lijfering, IA Naess… - Journal of Thrombosis …, 2012 - Elsevier
Background: High body mass index (BMI) is associated with an increased risk of venous
thrombosis (VT). Clotting factor VIII levels are increased in obese subjects, possibly because
of a chronic inflammatory state, which increases activated protein C (APC) resistance. The
APC resistance in FV Leiden carriers could be aggravated and further worsened by high
FVIII levels in blood group non‐O carriers. We hypothesized that an association exists
between BMI and APC resistance, and that this is amplified by the presence of FV Leiden …
thrombosis (VT). Clotting factor VIII levels are increased in obese subjects, possibly because
of a chronic inflammatory state, which increases activated protein C (APC) resistance. The
APC resistance in FV Leiden carriers could be aggravated and further worsened by high
FVIII levels in blood group non‐O carriers. We hypothesized that an association exists
between BMI and APC resistance, and that this is amplified by the presence of FV Leiden …