Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis

JI Odegaard, A Chawla - Science, 2013 - science.org
JI Odegaard, A Chawla
Science, 2013science.org
Metabolism and immunity are inextricably linked both to each other and to organism-wide
function, allowing mammals to adapt to changes in their internal and external environments.
In the modern context of obesogenic diets and lifestyles, however, these adaptive responses
can have deleterious consequences. In this Review, we discuss the pleiotropic actions of
inflammation and insulin resistance in metabolic homeostasis and disease. An appreciation
of the adaptive context in which these responses arose is useful for understanding their …
Metabolism and immunity are inextricably linked both to each other and to organism-wide function, allowing mammals to adapt to changes in their internal and external environments. In the modern context of obesogenic diets and lifestyles, however, these adaptive responses can have deleterious consequences. In this Review, we discuss the pleiotropic actions of inflammation and insulin resistance in metabolic homeostasis and disease. An appreciation of the adaptive context in which these responses arose is useful for understanding their pathogenic actions in disease.
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