[HTML][HTML] Migratory properties of pulmonary dendritic cells are determined by their developmental lineage

H Nakano, JE Burgents, K Nakano, GS Whitehead… - Mucosal …, 2013 - Elsevier
The chemokine receptor, CCR7, directs the migration of dendritic cells (DCs) from peripheral
tissue to draining lymph nodes (LNs). However, it is unknown whether all pulmonary DCs
possess migratory potential. Using novel Ccr7 gfp reporter mice, we found that Ccr7 is
expressed in CD103+ and a CD14 med/lo subset of CD11b hi classical (c) DCs but not in
monocyte-derived (mo) DCs, including Ly-6C hi CD11b hi inflammatory DCs and CD14 hi
CD11b hi DCs. Consequently, cDCs migrated to lung-draining LNs but moDCs did not. Mice …