Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes

AT Hastie, WC Moore, DA Meyers, PL Vestal… - Journal of Allergy and …, 2010 - Elsevier
BACKGROUND: Patients with severe asthma have increased granulocytes in their sputum
compared with patients with mild to moderate asthma. OBJECTIVE: We hypothesized that
inflammatory granulocytes in sputum may identify specific asthma severity phenotypes and
are associated with different patterns of inflammatory proteins in sputum supernatants.
METHODS: This hypothesis was tested in 242 patients with asthma enrolled in the Severe
Asthma Research Program who provided sputum samples for cell count, differential cell …